The preparation of teacher candidates is highly differentiated among teacher preparation programs across the country. With the increasing development of alternative teacher licensure (ATL) programs, these practices have been the source of considerable debate and contention. The purpose of this chapter is to: (a) provide a historical overview of teacher licensure; (b) review the literature regarding alternative teacher licensure and the needed knowledge base for teachers; and (c) discuss the role Career and Technical Education (CTE) plays in regards to ATL, as well as point out a misconception regarding the original inception of ATL. Further, future trends and implications for future research regarding ATL and the preparation of teachers are outlined.