The HLA-Dw2 haplotype segregates closely with multiple sclerosis in multiplex families

Hillert, Jan; Käll, Tor-Björn; Vrethem, Magnus; Fredrikson, Sten; Ohlson, Monica; Olerup, Olle

doi:10.1016/0165-5728(94)90219-4

Cited by 42 publications

(13 citation statements)

References 43 publications

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“…On the contrary, many researchers support evidence for a role of DR15 haplotype in family data sets [31,39]. We advocate that larger family-based studies are needed in order to resolve this issue.…”

Section: Discussionmentioning

confidence: 82%

HLA associations with multiple sclerosis in Greece

Kouri

Papakonstantinou

Bempes

et al. 2011

Journal of the Neurological Sciences

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Section: Discussionmentioning

confidence: 82%

HLA associations with multiple sclerosis in Greece

Kouri

Papakonstantinou

Bempes

et al. 2011

Journal of the Neurological Sciences

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“…HLA-DRB1*1501 has consistently proven its association in many case-control and familial genetic studies of MS risk and inheritance. (Hillert et al, 1994;Barcellos et al, 2006;Schmidt et al, 2007). However, the exact mechanism of how this haplotype increases susceptibility to MS is still unknown, but some evidence suggests its association in antigen detection, specifically EBV antigens.…”

Section: Introductionmentioning

confidence: 96%

Gender influence in EBV antibody response in multiple sclerosis patients from Kuwait

Al-Temaimi

Alroughani

Jacob

et al. 2015

Journal of Neuroimmunology

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“…MS is associated with the HLA-DRB1*1501-DQA1*0102-DQB1*0602 haplotype. 17 This haplotype occurs at a similar frequency in primary progressive MS, relapsing-remitting MS and secondary progressive MS; however, patients with primary progressive MS are more likely to have a DR6 haplotype combined with this haplotype. 18 Such a difference in MHC expression could result in different CNS antigens being targeted by the immune system and consequent differences in CNS repair and disease progression.…”

Section: Genetics Of Primary Progressive Msmentioning

confidence: 99%

The pathogenesis of primary progressive multiple sclerosis: antibody-mediated attack and no repair?

Pender

2004

Journal of Clinical Neuroscience

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Primary progressive multiple sclerosis (MS) differs from the more common form of MS which has an initial relapsing-remitting course in a number of ways, including pathological features, clinical course, differential diagnosis and response to treatment. The lesions in primary progressive MS tend to be more diffuse, less inflammatory and less likely to remyelinate than those occurring in relapsing-remitting MS and secondary progressive MS; there are also fewer focal lesions in the brain in primary progressive MS. Recent evidence suggests that antibodies to central nervous system (CNS) antigens have an important role in disease progression. Such antibodies could cause demyelination, inhibit remyelination and cause axonal destruction. Ongoing immune attack by autoantibody and lack of CNS repair could be responsible for the gradually increasing disability in primary progressive MS. Further research on the B-cell and autoantibody response in primary progressive MS might lead to advances in diagnosis and treatment. Inhibition of autoantibody production by inducing B-cell apoptosis with rituximab is a potential new therapy for primary progressive MS.

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The HLA-Dw2 haplotype segregates closely with multiple sclerosis in multiplex families

Cited by 42 publications

References 43 publications

HLA associations with multiple sclerosis in Greece

HLA associations with multiple sclerosis in Greece

Gender influence in EBV antibody response in multiple sclerosis patients from Kuwait

The pathogenesis of primary progressive multiple sclerosis: antibody-mediated attack and no repair?

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