1994
DOI: 10.1016/0165-5728(94)90219-4
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The HLA-Dw2 haplotype segregates closely with multiple sclerosis in multiplex families

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Cited by 42 publications
(13 citation statements)
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“…On the contrary, many researchers support evidence for a role of DR15 haplotype in family data sets [31,39]. We advocate that larger family-based studies are needed in order to resolve this issue.…”
Section: Discussionmentioning
confidence: 82%
“…On the contrary, many researchers support evidence for a role of DR15 haplotype in family data sets [31,39]. We advocate that larger family-based studies are needed in order to resolve this issue.…”
Section: Discussionmentioning
confidence: 82%
“…HLA-DRB1*1501 has consistently proven its association in many case-control and familial genetic studies of MS risk and inheritance. (Hillert et al, 1994;Barcellos et al, 2006;Schmidt et al, 2007). However, the exact mechanism of how this haplotype increases susceptibility to MS is still unknown, but some evidence suggests its association in antigen detection, specifically EBV antigens.…”
Section: Introductionmentioning
confidence: 96%
“…MS is associated with the HLA-DRB1*1501-DQA1*0102-DQB1*0602 haplotype. 17 This haplotype occurs at a similar frequency in primary progressive MS, relapsing-remitting MS and secondary progressive MS; however, patients with primary progressive MS are more likely to have a DR6 haplotype combined with this haplotype. 18 Such a difference in MHC expression could result in different CNS antigens being targeted by the immune system and consequent differences in CNS repair and disease progression.…”
Section: Genetics Of Primary Progressive Msmentioning
confidence: 99%