HLA associations with multiple sclerosis in Greece

Kouri, Ioanna; Papakonstantinou, Stylianos; Bempes, Vaios; Vasiliadis, Haris S.; Kyritsis, Athanasios P.; Pelidou, Sygkliti-Henrietta

doi:10.1016/j.jns.2011.06.037

Cited by 22 publications

(26 citation statements)

References 37 publications

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“…Hensiek et al confirmed that HLA-DR15 is associated with female sex in patients with multiple sclerosis [33]; although the results of this study indicate no association between the DRB1*1501 and gender. This result was in line with another study in Greece [14].…”

Section: Discussionsupporting

confidence: 93%

“…The recruited patients originated from south west of Iran. Our results are in line with most of the other previous studies in different ethnic groups in Iran [5][6][7]9] and European populations [12][13][14][15]25]. So we can conclude that HLA-DRB1*1501 can be considered as a strong genetic risk factor for MS in our population.…”

supporting

confidence: 92%

“…ferences between DRB1*1501-positive and negative patients were observed according to disease clinical course like some others studies [14]. Logistic regression analysis failed to show any association between HLA-DRB1*1501 and EDSS of MS; EDSS of MS in our sample of patients were similar to features published in observational studies of MS [7,9,14].…”

supporting

confidence: 86%

“…Logistic regression analysis failed to show any association between HLA-DRB1*1501 and EDSS of MS; EDSS of MS in our sample of patients were similar to features published in observational studies of MS [7,9,14]. This suggests that DRB1*1501 may be exerts a susceptibility rather than disease modifying effect in MS.…”

supporting

confidence: 77%

“…In most studies that have been performed in European populations, the frequency of HLA-DRB1*1501 in patients have been more than that of the controls [12][13][14][15][16][17][18]. In non-European populations, such as Brazilian and AfricanAmericans, also the association of HLA-DRB1*1501 and MS has been shown [19,20].…”

Section: Discussionmentioning

confidence: 99%

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Analysis of HLA-DRB1*1501 in Multiple Sclerosis Patients in Khuzestan Province, Iran

Delfan

Galehdari

Kazeminejad

et al. 2017

Zahedan J Res Med Sci

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Background: Multiple sclerosis (MS) is a demyelinating, autoimmune and neurodegenerative disease of the central nervous system (CNS). The pathogenesis of this disease is still unknown, although there are evidences of environmental factors affecting subjects with genetic predisposition factors. The contribution of HLA-DRB1*1501 to MS risk has been replicated and confirmed in most population-based studies. Since there are no data with respect to the association of HLA-DRB1*1501 and MS in Khuzestan province. Objectives: The aim of this study was to investigate the correlation of this allele with MS in Khuzestan province. Methods: In this case-control study, DRB1*1501 allele was analyzed by polymerase chain reaction with sequence-specific primers (PCR-SSP) in 200 MS patients and 200 unrelated healthy individuals, without any autoimmune disease from the same geographical region. The frequencies of the mentioned allele were compared between the patients and control group using SPSS 16 statistical software and the chi square test. Results:The results demonstrated that distribution of DRB1*1501 allele was statistically different between patient and control (41.5% vs. 22.81%, P < 0.001); significant correlation was observed among these allele with both Arab (28.84% vs. 50.84%, P = 0.005) and Persian (15.87% vs. 35.55%, P = 0.018) ethnicities; although no association was revealed between mentioned allele and disease clinical course (relapsing-remitting, secondary-progressive, progressive-relapsing and primary-progressive), expanded disability scale score (EDSS) and gender. Conclusions:The study presents association of susceptibility to multiple sclerosis in southwest of Iran with HLA-DRB1*1501 allele in both Arab and Persian ethnic; although DRB1*1501 may be is not involved in the pathogenesis of different MS disease subtypes. The results are consistent with most of the other studies in Iran; and also most studies in European populations.

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Section: Discussionsupporting

confidence: 93%

supporting

confidence: 92%

supporting

confidence: 86%

supporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Analysis of HLA-DRB1*1501 in Multiple Sclerosis Patients in Khuzestan Province, Iran

Delfan

Galehdari

Kazeminejad

et al. 2017

Zahedan J Res Med Sci

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The Role of HLA in MS Susceptibility and Phenotype

Greer

2014

Emerging and Evolving Topics in Multiple Sclerosis Pathogenesis and Treatments

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One of the most consistent findings in multiple sclerosis (MS) is that development of MS is linked with carriage of the class II human leucocyte antigen (HLA) molecule HLA-DRB1*15:01; around 60 % of Caucasian MS patients carry this allele compared to 25-30 % of ethnically matched healthy individuals. However, other HLA molecules have also been linked to the development of MS. In this chapter, the association between different HLA types and susceptibility to MS will be reviewed, and other linkages between the carriage of specific HLA molecules and clinical and experimental findings in MS will be considered.

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