The HLA-Cw*06 allele and −1149 G/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech population

Cibulova, Anna; Zajacova, Marta; Fojtíková, Markéta; Štolfa, Jiří; Šedová, Liliana; Cejkova, Pavlina; Lippert, Jan; Arenberger, Petr; Černá, Marie

doi:10.1007/s00296-012-2472-7

Cited by 8 publications

(4 citation statements)

References 38 publications

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“…Regardless of the differences of HLA‐Cw6 frequency in patients with PsA, HLA‐Cw6 is associated with early age of onset in both PsA and PsV. HLA‐Cw6 genotype is reported to be associated with early age of onset in patients with PsA, characterized by positive family history, severe psoriasis, clinical enthesitis, polyarthritis, oligoarthritis, axial pattern on disease onset and mixed pattern during evolution . For the other types of PsA, HLA‐Cw6 status is not associated with dactylitis in patients with PsA .…”

Section: Association With Psoriatic Arthritismentioning

confidence: 97%

“…The worldwide HLA‐Cw6 allele frequency varies greatly and can range from 14·1% to 59·1%, whereas the percentage of patients with psoriasis carrying HLA‐Cw6 ranges from 10·5% to 77·2% (Table ) . Such wide ranges may be attributed to small sample sizes, ethnic diversity and differences in inclusion criteria.…”

Section: Hla‐cw6 Allele Frequency In Patients With Psoriasismentioning

confidence: 99%

“…Differences in the frequency of psoriasis may be explained by environmental factors, such as humidity, as well as other as yet unidentified genes. Despite the well recognized association between HLA‐Cw6 and familial psoriasis, some studies have reported a lack of correlation between HLA‐Cw6 and family history . A recessive inheritance may be present or other alleles may affect heritability of psoriasis.…”

Section: Hla‐cw6 Allele Frequency In Patients With Psoriasismentioning

confidence: 99%

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HLA-Cw6 and psoriasis

Chen

Tsai

2018

British Journal of Dermatology

116

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Psoriasis is a multifactorial disease with a strong genetic background. HLA-Cw6 is one of the most strongly associated psoriasis susceptibility alleles. It is repeatedly observed to affect disease course, phenotypic features, severity, comorbidities and treatment outcomes. To the best of our knowledge, the roles of HLA-Cw6 in psoriasis have not yet been thoroughly reviewed. The worldwide frequency of the HLA-Cw6 allele varies greatly, with it being generally higher in white people than in Asians. The allele is associated with type I early-onset psoriasis. Stress, obesity and streptococcal pharyngitis are commonly observed in HLA-Cw6-positive patients. Phenotypically, HLA-Cw6 has been found to be associated with guttate psoriasis. In addition, patients carrying the allele are more likely to have arm, leg and trunk involvement, and the Koebner phenomenon. Patients with psoriatic arthritis with HLA-Cw6 more often have early onset and tend to show cutaneous symptoms before musculoskeletal symptoms. HLA-Cw6-positive patients have been shown in several studies to be more responsive to methotrexate and ustekinumab. However, this difference in ustekinumab efficacy was only moderate in a post-hoc analysis of a pivotal phase III study. HLA-Cw6 positivity also tends to be less frequent in high-need patients who fail conventional therapy. Small studies have also investigated the role of HLA-Cw6 in remission of psoriasis during pregnancy, and with the comorbidities of photosensitivity and atherosclerosis. Given the diverse nature of psoriasis pathogenesis, as well as the difference of HLA-Cw6 positivity in different ethnic groups, more studies are needed to confirm the role of HLA-Cw6 in psoriasis.

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Section: Association With Psoriatic Arthritismentioning

confidence: 97%

Section: Hla‐cw6 Allele Frequency In Patients With Psoriasismentioning

confidence: 99%

Section: Hla‐cw6 Allele Frequency In Patients With Psoriasismentioning

confidence: 99%

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HLA-Cw6 and psoriasis

Chen

Tsai

2018

British Journal of Dermatology

116

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“…Gudjonsson et al demonstrated that heterozygotes have a relative risk of developing psoriasis of 8.9, whereas homozygotes have a relative risk of 23.1, with earlier disease onset being more common in this group [11]. Cibulova et al found HLA-Cw*0602 to be the most prominent HLA in Type I PsV, correlating well with an earlier disease onset and a family history of psoriasis [12]. This finding was echoed in siblings discordant for HLA-Cw*0602, where the positive HLA-Cw*0602 sibling had significantly early disease onset [13].…”

Section: Genetic Susceptibility Locimentioning

confidence: 99%

Interactions of the Immune System with Skin and Bone Tissue in Psoriatic Arthritis: A Comprehensive Review

Sukhov

Adamopoulos

Maverakis

2016

Clinic Rev Allerg Immunol

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Cutaneous psoriasis [e.g. psoriasis vulgaris (PsV)] and psoriatic arthritis (PsA) are complex heterogeneous diseases thought to have similar pathophysiology. The soluble and cellular mediators of these closely related diseases are being elucidated through genetic approaches such as genome-wide association studies (GWAS), as well as animal and molecular models. Novel therapeutics targeting these mediators (IL-12, IL-23, IL-17, IL-17 receptor, TNF) are effective in treating both the skin and joint manifestations of psoriasis, reaffirming the shared pathophysiology of PsV and PsA. However, the molecular and cellular interactions between skin and joint disease have not been well characterized. Clearly, PsV and PsA are highly variable in terms of their clinical manifestations and this heterogeneity can partially be explained by differences in HLA-associations (HLA-Cw*0602 versus HLA-B*27, for example). In addition, there are numerous other genetic susceptibility loci (LCE3, CARD14, NOS2, NFKBIA, PSMA6, ERAP1, TRAF3IP2, IL12RB2, IL23R, IL12B, TNIP1, TNFAIP3, TYK2) and geoepidemiologic factors that contribute to the wide variability seen in psoriasis. Herein we review the complex interplay between the genetic, cellular, ethnic and geographic mediators of psoriasis, focusing on the shared mechanisms of PsV and PsA.

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The HLA-C*06 allele as a possible genetic predisposing factor to psoriasis in South Indian Tamils

et al. 2016

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Psoriasis is a multi-factorial heritable prototypical immune-mediated inflammatory disease, characterized by hyperproliferation of keratinocytes in the affected skin. There are no studies till date, to the best of our knowledge, about the association of HLA-C*06, the risk variant in the PSORS 1 susceptibility locus that confers the greatest risk for early onset of psoriasis, with the disease in South Indian Tamil patients with psoriasis. The present study was performed to determine the association of HLA-C*06 with psoriasis in the South Indian Tamil ethnic population. Three hundred and fifty-five cases of psoriasis and 360 healthy controls were included in this case-control study. Severity grading according to psoriasis area severity index (PASI) scoring was done in patients with psoriasis. PCR assays with sequence-specific primers (PCR-SSP) were used for specific detection of HLA-C*06. PCR with analysis of restriction fragment length polymorphism was used to distinguish between patients homozygous and heterozygous for HLA-C*06. We observed that those with the HLA-C*06-positive allele had a 3.5 times higher odds of having psoriasis compared to those without, [p < 0.0001, OR 3.5, 95 % CI (2.59-4.79)]. Among cases of psoriasis, it was noted that there was a significant association of HLA-C*06 positivity with female psoriatics [p = 0.006; OR 2.49 (1.28-4.87)] and early age of onset of psoriasis [p = 0.002; OR 2.04 (1.29-3.20)]. Our results suggest that the HLA-C*06 allele is positively associated with susceptibility to psoriasis, female gender and early onset of psoriasis in South Indian Tamils.

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The HLA-Cw*06 allele and −1149 G/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech population

Cited by 8 publications

References 38 publications

HLA-Cw6 and psoriasis

HLA-Cw6 and psoriasis

Interactions of the Immune System with Skin and Bone Tissue in Psoriatic Arthritis: A Comprehensive Review

The HLA-C*06 allele as a possible genetic predisposing factor to psoriasis in South Indian Tamils

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