The HLA-A:HLA-B crossovers and their contribution in analysing possible haplotype-specific recombination rates

Bender, Klaus

doi:10.1007/bf00274202

Cited by 8 publications

(2 citation statements)

References 33 publications

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“…Haplotype-specific recombination rates have been established earlier by Bender (1982) in 133 HLA-A/B cross-overs. No difference was found between recombinant and non-recombinant haplotypes.…”

Section: First Solutionmentioning

confidence: 98%

Recombination Fractions in the Hla System Based on the Data Set ‘Provinces Françaises’: Indications of Haplotype‐specific Recombination Rates

Thomsen

Neugebauer

Arnaud

et al. 1994

Int J Immunogenetics

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In the large genetic survey "Provinces Françaises' the recombination fractions in the HLA system have been estimated by a family analysis programme (FAP). A total of 1332 families were analysed and in general the findings were in agreement with recombination fractions reported previously. The maternal recombination rates were on average 1.8 times higher than the corresponding ones for males. The comparison of the recombination fractions with the corresponding physical distances suggests the existence of hot spots of recombination. The analysis did not show deviations from expected values for HLA-A and B alleles on HLA-A/B recombinant haplotypes. However, analysis of HLA-B/DR recombinant haplotypes showed a skewed distribution of B and DR alleles. The significance of the findings is difficult to evaluate as all results are estimated numbers and frequencies but a manual analysis of the recombinant families confirmed the observations. HLA-B/DR recombinant haplotypes carried often HLA-DR3 and DR11 whereas DR2 and DR7 were more rarely present on recombinant haplotypes. DR4 had an increased incidence on BF/DR recombinant haplotypes but not on A/B or B/BF recombinant haplotypes. Some of the haplotypes with the strongest linkage disequilibria as A1,B8,DR3 and A3,B7,DR2 seem to be less frequently involved in recombinations than other haplotypes. Variations of recombination rates depending on certain alleles or haplotypes might partially explain the conservation of some haplotypes or part of haplotypes in Caucasoids.

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Section: First Solutionmentioning

confidence: 98%

Recombination Fractions in the Hla System Based on the Data Set ‘Provinces Françaises’: Indications of Haplotype‐specific Recombination Rates

Thomsen

Neugebauer

Arnaud

et al. 1994

Int J Immunogenetics

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show abstract

“…Cudworth et al (1979) also found some male transmission bias for HLA-A1 , B8 haplotypes (63-65%) while Bender (1982) in studying 133 published cases with HLA-A : B crossovers was unable to demonstrate a haplotype specific recombination rate. At this workshop, Gedde-Dahl et al (1984) report that they were unable to demonstrate segregation distortion for the same haplotype that Awdeh et al (1983) studied and furthermore, that it does not suppress recombination for HLA :PGM3.…”

Section: Is There a T Homolog In Man?mentioning

confidence: 99%