Comparative map for mice and humans

Nadeau, Joseph H.; Davisson, Muriel T.; Doolittle, Donald P.; Grant, Patricia; Hillyard, A.L.; Kosowsky, Michael; Roderick, Thomas H.

doi:10.1007/bf00656504

Cited by 52 publications

(19 citation statements)

References 1,105 publications

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“…Interestingly, the mouse (ib locus and the ratfa locus <are thought to be encoded in a chromosomal region of these animal models of obesity which is thought to have a high degree of homology with the human lp31-ter (13,19). Even though there is no association or linkage data supporting a relationship between GLUT-1 and obesity, the GLUT-1 locus has been mapped to 1~31-35 and it remains of potential interest as a marker locus not only for obesity but also for the glucose metabolism disturbances commonly observed in the obese state.…”

Section: Discussionmentioning

confidence: 99%

An Exploratory Investigation of Genetic Linkage with Body Composition and Fatness Phenotypes: The Québec Family Study

et al. 1994

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I n tlie present investigation, we have attempted to identify regions of tlie genome in which "obesity genes" potentially reside using robust sib-pair linkage analysis. Data were collected on 1,628 intlivicluals in 301 nuclear families residing in the environs of Qu6bec City during tlie period [1978][1979][1980][1981]. In adtlition to traditional I,lood group antigens and enzyme polyniorpliisms, several phenotypes in tlie obesity domain that are associated with increased morbidity were assessed, including measures relating to heaviness (i.e., the body mass index), body composition and nutrient partitioning (i.e., % body fat), and regional fat distribution without and with stanclarclization for total fat niass (i.e., the sum of six skinfold thicknesses, and the ratio of tlie sums of trunk to extremity skinfold thicknesses). Three consistent patterns of potential linkage relationships with obesity phenotypes were revealed in these data, involving tlie marker loci adenosine deaniinase, tlie Kell blood group antigen, and esterase D, which identify cliromosomal regions 20~113, 7~133, and 13114, respectively. Other potential linkages also were identified in the short a r m of chromosome 1, interesting because of tlie presence of the db and f i t loci on lioniologous regions of chromosome 1 in mouse and rat models of obesity, respectively. Each of the tentative linkage relationships reported here warrant follow-up using alternative nietliods and require replication in intlependent studies.

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Section: Discussionmentioning

confidence: 99%

An Exploratory Investigation of Genetic Linkage with Body Composition and Fatness Phenotypes: The Québec Family Study

et al. 1994

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“…Genes on the long arm of human chromosome 1 have mapped principally to mouse chromosome 1, including blood coagulation factor V. 51 - 52 Other blood coagulation factor genes mapped in the mouse are those for factors VIII and IX, which are on the X chromosome as they are in humans. 45 Comparison of the nucleotide sequence of the murine and human TF promoters allows identification of conserved regions that may serve regulatory roles. Both promoters are spanned by a G+C-rich region that fits the criteria of a CpG island, although the role of this region in the regulation of the TF gene is currently unknown.…”

Section: Discussionmentioning

confidence: 99%

Structure of the murine tissue factor gene. Chromosome location and conservation of regulatory elements in the promoter.

Mackman

Imes

Maske

et al. 1992

Arterioscler Thromb

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Tissue factor (TF) is a transmembrane glycoprotein that mediates cellular initiation of the coagulation serine protease cascades. Moreover, expression of TF in human atherosclerotic plaques is likely to play a significant role in the thrombotic complications associated with plaque rupture. In this study the complete murine TF gene, Cf-3, was isolated from mouse NIH 3T3 cells and was found to consist of six exons spanning about 11 kilobase pairs (kbp) of DNA. A major transcriptional start site was located 24 bp downstream of a TATA box. Cf-3 was mapped to chromosome 3 by analysis of an intersubspecies test cross. Conserved transcription factor-binding sites were identified by comparison of 5' flanking regions of the murine and human TF genes. A region of the TF promoter required for constitutive expression exhibited 85% identity in DNA sequence and included two conserved binding sites for Spl. Furthermore, two AP-1 sites and an NF-KB site were conserved in a 56-bp region necessary for transcriptional activation in response to bacterial lipoporysaccharide. These highly conserved regions of the TF promoter, which contain several binding sites for well-characterized transcription factors, are likely to be functionally important in the complex pattern of TF gene expression observed in a variety of cell types. 1 These proteins may share a common global architecture of binding domains based on the conservation of two pairs of cysteine residues.2 TF initiates the coagulation serine protease cascades by forming a complex with circulating factors VII/VIIa. 3Under normal circumstances TF is not expressed within the vasculature. However, TF expression can be rapidly induced in cultured peripheral blood monocytes and human umbilical vein endothelial cells in response to a variety of agonists, including bacterial lipoporysaccharide (LPS) and the inflammatory cytokines tumor necrosis factor-a (TNF-a) and interleukin-1 (IL-1). 4 -7 Activation of the coagulation protease cascades by

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“…Synteny homology between mice and humans suggested that Crh would map to mouse Chr 3, 4, 8, or 15 (Nadeau et al 1992).…”

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confidence: 99%

Corticotropin-releasing hormone (Crh) maps to mouse Chromosome 3

et al. 1993

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Comparative map for mice and humans

Cited by 52 publications

References 1,105 publications

An Exploratory Investigation of Genetic Linkage with Body Composition and Fatness Phenotypes: The Québec Family Study

An Exploratory Investigation of Genetic Linkage with Body Composition and Fatness Phenotypes: The Québec Family Study

Structure of the murine tissue factor gene. Chromosome location and conservation of regulatory elements in the promoter.

Corticotropin-releasing hormone (Crh) maps to mouse Chromosome 3

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