The history of sentinel node biopsy in head and neck cancer: From visualization of lymphatic vessels to sentinel nodes

Bree, Remco de; Nieweg, Omgo E.

doi:10.1016/j.oraloncology.2015.06.006

Cited by 44 publications

(27 citation statements)

References 51 publications

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“…Advanced ipsilateral neck disease may not independently increase the risk of contralateral disease recurrence. For example, to the best of our knowledge, anatomic and lymphatic mapping studies have not identified connections between opposite lymph node regions I to IV of the neck . Therefore, it may be that contralateral lymph node disease occurs because the primary tumor approaches the midline, resulting in contralateral metastasis, or because the tumor invades a region with extensive submucosal lymphatics such as the tongue or floor of the mouth .…”

Section: Discussionmentioning

confidence: 99%

Comparison of unilateral versus bilateral intensity‐modulated radiotherapy for surgically treated squamous cell carcinoma of the palatine tonsil

Chin

Rao

Hwang

et al. 2017

Cancer

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Section: Discussionmentioning

confidence: 99%

Comparison of unilateral versus bilateral intensity‐modulated radiotherapy for surgically treated squamous cell carcinoma of the palatine tonsil

Chin

Rao

Hwang

et al. 2017

Cancer

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“…At many centers, the decision to perform neck dissection is currently based upon SNB results [32]. A recent large randomized study demonstrated better survival in patients that are treated with an upfront neck dissection as opposed to treating neck recurrence [5], which underlines the importance of correct staging of the neck at diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Construction of a pathological risk model of occult lymph node metastases for prognostication by semi-automated image analysis of tumor budding in early-stage oral squamous cell carcinoma

et al. 2017

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It is challenging to identify at diagnosis those patients with early oral squamous cell carcinoma (OSCC), who have a poor prognosis and those that have a high risk of harboring occult lymph node metastases. The aim of this study was to develop a standardized and objective digital scoring method to evaluate the predictive value of tumor budding. We developed a semi-automated image-analysis algorithm, Digital Tumor Bud Count (DTBC), to evaluate tumor budding. The algorithm was tested in 222 consecutive patients with early-stage OSCC and major endpoints were overall (OS) and progression free survival (PFS). We subsequently constructed and cross-validated a binary logistic regression model and evaluated its clinical utility by decision curve analysis. A high DTBC was an independent predictor of both poor OS and PFS in a multivariate Cox regression model. The logistic regression model was able to identify patients with occult lymph node metastases with an area under the curve (AUC) of 0.83 (95% CI: 0.78–0.89, P <0.001) and a 10-fold cross-validated AUC of 0.79. Compared to other known histopathological risk factors, the DTBC had a higher diagnostic accuracy. The proposed, novel risk model could be used as a guide to identify patients who would benefit from an up-front neck dissection.

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“…In addition, the complex lymphatic drainage patterns in the HN could increase the risk of local/regional relapses after surgery alone 5, 34, 35, 36. Given these concerns, we hypothesized that even patients with low-risk Stage IA HN MCC may be at a greater risk of developing an LR if they are treated with surgery alone.…”

Section: Discussionmentioning

confidence: 99%

Postoperative radiation therapy is associated with a reduced risk of local recurrence among low risk Merkel cell carcinomas of the head and neck

Takagishi

Marx

Lewis

et al. 2016

Advances in Radiation Oncology

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PurposeMerkel cell carcinoma (MCC) is a rare and often aggressive skin cancer. Typically, surgery is the primary treatment. Postoperative radiation therapy (PORT) is often recommended to improve local control. It is unclear whether PORT is indicated in patients with favorable Stage IA head and neck (HN) MCC.Methods and materialsWe conducted a retrospective analysis of 46 low-risk HN MCC cases treated between 2006 and 2015. Inclusion criteria were defined as a primary tumor size of ≤ 2 cm, negative pathological margins, negative sentinel lymph node biopsy, and no immunosuppression. Local recurrence (LR) was defined as tumor recurrence within 2 cm of the primary surgical bed and estimated with the Kaplan-Meier method.ResultsOmission of PORT was offered to all 46 patients, of which 23 patients received PORT and 23 did not. No patient received adjuvant chemotherapy. There were no significant differences in surgical margins, tumor size, depth, lympho-vascular invasion status, or demographics between the two patient groups. Median follow-up for all patients was 3.7 years. Six of the 23 patients who did not receive PORT developed an LR. Compared to the group that received PORT, there was a significantly higher risk of LR in the group treated without PORT (26% vs. 0%, P = .02). Median time to LR was 11 months. All local failures were effectively salvaged. There was no difference in MCC-specific and overall survival between the 2 groups.ConclusionsFor patients with HN MCC, omission of PORT was associated with a significantly higher risk of local recurrence even among those patients with the lowest-risk tumors (i.e., Stage IA without immune suppression). Thus, it is important to weigh the benefits of PORT against the side effect profile on a case-specific basis for each patient.

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The history of sentinel node biopsy in head and neck cancer: From visualization of lymphatic vessels to sentinel nodes

Cited by 44 publications

References 51 publications

Comparison of unilateral versus bilateral intensity‐modulated radiotherapy for surgically treated squamous cell carcinoma of the palatine tonsil

Comparison of unilateral versus bilateral intensity‐modulated radiotherapy for surgically treated squamous cell carcinoma of the palatine tonsil

Construction of a pathological risk model of occult lymph node metastases for prognostication by semi-automated image analysis of tumor budding in early-stage oral squamous cell carcinoma

Postoperative radiation therapy is associated with a reduced risk of local recurrence among low risk Merkel cell carcinomas of the head and neck

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