The historical milestones in the understanding of leukocyte biology initiated by Elie Metchnikoff

Cavaillon, Jean‐Marc

doi:10.1189/jlb.0211094

Cited by 94 publications

(80 citation statements)

References 109 publications

(89 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The phagocytic macrophages were first discovered by Ilya Metchnikoff in 1884 [89,90]. They differentiates from hematopoietic stem cell (HSCs) and are present in most tissues.…”

Section: Macrophages and The Innate Immune Systemmentioning

confidence: 99%

Aquaporins in Infection and Inflammation

Holm¹

2016

Linköping University Medical Dissertations

View full text Add to dashboard Cite

About the cover:The front cover displays a human, blood-derived macrophage stained for aquaporin 9.During the course of the research underlying this thesis, Angelika Holm was enrolled in Forum Scientium, a multidisciplinary doctoral programme at Linköping University Printed by LiU-Tryck, Linköping, Sweden, 2016 "Be brave, even if you're not, pretend to be. No one can tell the difference."To that young, awkward, tall girl who dared to dream of something else, something more:You did it. SUPERVISOR Elena VikströmDepartment of Clinical and Experimental Medicine Linköping University Linköping Sweden When cells of the innate immune system encounter pathogens they need to respond and prepare for migration and phagocytosis and do so through volume regulatory processes. The Gramnegative bacterium Pseudomonas aeruginosa utilizes a small molecule-based communication system, called quorum sensing (QS) to control the production of its virulence factors and biofilms. We found that P. aeruginosa with a complete QS system elicits a stronger phagocytic response in human blood-derived macrophages compared to its lasI-/rhlI-mutant lacking the production of the QS molecules N-butyryl-L-homoserine lactone (C4-HSL) and N-3-oxododecanoyl-L-homoserine lactone (3O-C12-HSL). Infection with P. aeruginosa further increases the expression of AQP9 and induces re-localisation of AQP9 to the front and trailing ends of macrophages. Moreover, the 3O-C12-HSL alone elevates the expression of AQP9, redistribute the water channel to the front and rear ends and increases the cell area and volume of macrophages. Both infection with the wild type P. aeruginosa and the treatment with 3O-C12-HSL change the nano-structural architecture of the AQP9 distribution in macrophages. ASSISTANT SUPERVISORS Karl-Eric MagnussonViruses use the intracellular machinery of the invaded cells to produce and assemble new viral bodies. Intracellular AQPs are localised in a membranes of cellular organelles to regulate their function and morphology. C3H10T1/2 fibroblasts transiently expressing green fluorescent protein (GFP)-AQP6 show a reduced expression of AQP6 after Hazara virus infection and an increased cell area. Overexpressing AQP6 in C3H10T1/2 cells reduces the infectivity of Hazara virus indicating that AQP6 expression has a protective role in virus infections.Ion and water channels in the epithelial cell lining tightly regulate the water homeostasis. In microscopic colitis (MC), patients suffer from severe watery diarrhoeas. For the first time, we have shown that the expression of AQP1, 8 and 11 and the sodium/hydrogen exchanger NHE1 are reduced in colonic biopsies from MC patients compared to healthy control individuals. Following treatment with the glucocorticoid budesonide the patients experienced a rapid recovery and we observed a restored or increased expression of the AQPs and NHE1 during treatment, suggesting a role for AQPs in the diarrhoeal mechanisms in MC.Taken together, this thesis provides new evidence on the importance of water homeostasis regulatio...

show abstract

“…The phagocytic macrophages were first discovered by Ilya Metchnikoff in 1884 [89,90]. They differentiates from hematopoietic stem cell (HSCs) and are present in most tissues.…”

Section: Macrophages and The Innate Immune Systemmentioning

confidence: 99%

Aquaporins in Infection and Inflammation

Holm¹

2016

Linköping University Medical Dissertations

View full text Add to dashboard Cite

show abstract

“…Mononuclear phagocytes have been recognized for their role in antimicrobial immunity since their initial description (7). Categorized as monocytes, macrophages, and dendritic cells (DC), the mononuclear phagocyte system is characterized by marked heterogeneity and incompletely defined cellular lineages (13).…”

mentioning

confidence: 99%

Heterogeneity of lung mononuclear phagocytes during pneumonia: contribution of chemokine receptors

Chen

Zhang

Barletta³

et al. 2013

American Journal of Physiology-Lung Cellular and Molecular Phys

View full text Add to dashboard Cite

Bacterial pneumonia is a common and dangerous illness. Mononuclear phagocytes, which comprise monocyte, resident and recruited macrophage, and dendritic cell subsets, are critical to antimicrobial defenses, but the dynamics of their recruitment to the lungs in pneumonia is not established. We hypothesized that chemokine-mediated traffic of mononuclear phagocytes is important in defense against bacterial pneumonia. In a mouse model of Klebsiella pneumonia, circulating Ly6Chi and, to a lesser extent, Ly6Clo monocytes expanded in parallel with accumulation of inflammatory macrophages and CD11bhi dendritic cells and plasmacytoid dendritic cells in the lungs, whereas numbers of alveolar macrophages remained constant. CCR2 was expressed by Ly6Chi monocytes, recruited macrophages, and airway dendritic cells; CCR6 was prominently expressed by airway dendritic cells; and CX3CR1 was ubiquitously expressed by blood monocytes and lung CD11bhi dendritic cells during infection. CCR2-deficient, but not CCL2-, CX3CR1-, or CCR6-deficient animals exhibited worse outcomes of infection. The absence of CCR2 had no detectable effect on neutrophils but resulted in reduction of all subsets of lung mononuclear phagocytes in the lungs, including alveolar macrophages and airway and plasmacytoid dendritic cells. In addition, absence of CCR2 skewed the phenotype of lung mononuclear phagocytes, abrogating the appearance of M1 macrophages and TNF-producing dendritic cells in the lungs. Taken together, these data define the dynamics of mononuclear phagocytes during pneumonia.

show abstract

“…Macrophages were discovered by Ilja Iljitsch Metschnikow in 1884 (Zalkind, 2001;Cavaillon, 2011) and named after their capability to engulf and digest cellular debris or foreign substances. In recent years, it has become increasingly clear that the term macrophage describes a heterogeneous group of cells diverse in terms of lineage and functionality (Yona et al, 2013;Varol et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Macrophages: sentinels and regulators of the immune system

Franken¹,

Schiwon²,

Kurts³

2016

Cellular Microbiology

147

View full text Add to dashboard Cite

Summary The important role of macrophages in host defense against a variety of pathogens has long been recognized and has been documented and reviewed in numerous publications. Recently, it has become clear that tissue macrophages are not entirely derived from monocytes, as has been assumed for a long time, but rather show an ontogenetic dichotomy in most tissues: while part of the tissue macrophages are derived from monocytes, a major subset is prenatally seeded from the yolk sac. The latter subset shows a remarkable longevity and is maintained by self‐renewal in the adult animal. This paradigm shift poses interesting questions: are these two macrophage subsets functionally equivalent cells that are recruited into the tissue at different development stages, or are both macrophage subsets discrete cell types with distinct functions, which have to exist side by side? Is the functional specialization that can be observed in most macrophages due to their lineage or due to their anatomical niche? This review will give an overview about what we know of macrophage ontogeny and will discuss the influence of the macrophage lineage and location on their functional specialization.

show abstract

The historical milestones in the understanding of leukocyte biology initiated by Elie Metchnikoff

Cited by 94 publications

References 109 publications

Aquaporins in Infection and Inflammation

Aquaporins in Infection and Inflammation

Heterogeneity of lung mononuclear phagocytes during pneumonia: contribution of chemokine receptors

Macrophages: sentinels and regulators of the immune system

Contact Info

Product

Resources

About