The Histopathotogy of the Skin Basal Cell Carcinoma with Areas of Intermediate Differentiation

Ber EP4 and epithelial membrane antigen aid distinction of basal cell, squamous cell and basosquamous carcinomas of the skin

“…Distinction of these entities has great clinical relevance since basal cell carcinoma rarely metastasizes and may be treated with local radiotherapy, whereas basosquamous and squamous cell carcinoma have a distinct risk of metastasis and radiotherapy may be inappropriate. 8–10 In some tumours categorization is difficult and probably highly subjective 1,11 . This is particularly the case where biopsies are small or the lesion ulcerated.…”

Basosquamous Carcinoma

“…Bowman et al suggest that this tumor behaves more aggressively than SCC. Metastasizing BCC is felt by some to be metatypical or basosquamous cell carcinoma 1 . Unfortunately, variables that predicate the risk of metastasis, such as Clark's level or depth of invasion and presence of perineural invasion, were not noted in this series 2 .…”

Basal cell carcinoma: Epidemiology, clinical and histologic features, and basic science overview

“…Another instance that can mimic this tumor is when one finds a collision tumor with BCC and cSCC components 37 . If correctly identified, metatypical BCCs are associated with increased recurrences and even distant metastases [56][57][58] . Occurrence of cSCC among patients receiving this therapy was recently reported [67][68][69] .…”