The histopathological changes comparison in healthy rabbit lung ventilated with ZEEP, Sigh and PEEP

Yardimci, Cevdet; Meyanci, G.; Öz, Hüseyin; Paksoy, İnci

doi:10.1186/cc1097

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was fully defined in animal models, but the significance in humans has not been established. Several studies suggest that the adverse effects of mechanical ventilation can be reduced by the application of PEEP (Webb HH et al 1974;Argiras EP et al 1987;Dreyfuss D et al 1988;Sandhar BK et al 1988;Yardimci Ç et al, 2001). Ventilation washed isolated rat lung airways with low volume (5-6 mL/kg) and low PEEP or PEEP equal to zero, causing lung injury that can be reduced by high levels of PEEP (Muscedere JG et al, 1994).…”

Section: # Paco2 -The Partial Pressure Of Carbon Dioxide In Arterial mentioning

confidence: 99%

Comparative analysis of changes in the lungs of experimental animals’ induced conventional and lung protective ventilation

Videnović

Mladenović²,

Videnovic³

et al. 2018

J Hellenic Vet Med Soc

View full text Add to dashboard Cite

Mechanical ventilation has long been the leader in the treatment of critically ill and injured patients in an intensive care unit. The aim of this study was to examine the impact of the application of positive end-expiratory pressure on histopathological findings and on the parameters of ventilation, oxygenation and acid-base status. The experimental study included 42 animals (piglets), which were divided into of tree groups, each containing 14. The animals of the control group (conventional ventilation) were ventilated with the tidal volume of 10-15 mL/kg. Tidal volume of 6 mL/kg was applied in the low tidal ventilation group, whereas the ventilation strategy in the lung protective ventilation group meant the application of a tidal volume of 6 mL/kg and the 7 mbar of positive end-expiratory pressure. Mechanical ventilation in each animal lasted for 4 hours. After conducting mechanical ventilation, samples were taken from the lung tissue, which were sent for histopathological examination. The parameters of ventilation, oxygenation and acid-base status were measured after each hour’s duration of mechanical ventilation. Application of positive end-expiratory pressure 5-10 mbar during mechanical ventilation is a safe and useful method which is not followed by the occurrence of significant abnormalities in the structure of the ventilated lung. However, a low tidal volume without positive end-expiratory pressure causes significant changes in the histological structure of healthy lungs. Positive end-expiratory pressure keeps the alveoli open throughout the respiratory cycle which allows the lungs to maintain homeostasis in terms of adequate ventilation, oxygenation and acid-base status.

show abstract

Section: # Paco2 -The Partial Pressure Of Carbon Dioxide In Arterial mentioning

confidence: 99%

Comparative analysis of changes in the lungs of experimental animals’ induced conventional and lung protective ventilation

Videnović

Mladenović²,

Videnovic³

et al. 2018

J Hellenic Vet Med Soc

View full text Add to dashboard Cite

show abstract

The histopathological changes comparison in healthy rabbit lung ventilated with ZEEP, Sigh and PEEP

Abstract: P14 Facial continuous positive airway pressure therapy for cardiogenic pulmonary oedema: a study of its efficacy in an emergency department setting within the UK

Cited by 1 publication

References 0 publications

Comparative analysis of changes in the lungs of experimental animals’ induced conventional and lung protective ventilation

Comparative analysis of changes in the lungs of experimental animals’ induced conventional and lung protective ventilation

Contact Info

Product

Resources

About