The histology of sclerotic human root dentine

Immunohistochemical localization of dentin matrix protein 1 in human dentin

“…Once the tooth formation is completed, dentinogenesis continues at a slower rate, resulting in secondary dentin production under physiological conditions, whereas tertiary dentin is formed in response to noxious external stimuli, being classified into reparative dentin and reactionary dentin (reviewed in Smith and Lesot 2001;Goldberg and Smith 2004;Moses et al 2006). During the physiologic response there is a continuous deposition of peritubular dentin, probably due also to defence mechanisms occurring during pathological insults such as caries (Vasiliadis et al 1983;Schüpbach et al 1992;Nanci, 2007). In particular, DMP1 has been shown to have similar functions as dentin sialophosphoprotein and to be detected in primary dentin with a marked decrease in tertiary dentin (Moses et al 2006).…”

Citric acid etching of cervical sclerotic dentin lesions: An AFM study

“…In addition, the mineral deposits that were present indicate another distinctly different structure is present in the sclerotic areas, as is well known. [2][3][4][5][6] Sclerotic lesions are well known to respond to etching and bonding treatments differently from normal dentin, thus leading to varying responses and complications during clinical treatment. [7][8][9][10][11] The results of this study contribute to our understanding of the difficulties in restoring such lesions with current bonding procedures.…”

“…Other tubules had varying degrees of tubule lumen reduction. Vasiliadis et al 4 also reported that sclerosis occurred by occlusion of dentinal tubules by mineral, with a refractive index similar to that of dentin, and that translucence occurred before a majority of tubules were completely occluded. Yoshiyama et al 5 found that for insensitive (sclerotic) dentin about 75% of the tubules were closed.…”

On the Mechanics of Fatigue and Fracture in Teeth

“…This rise in number of elderly patients has become another important concern in dentistry. Interestingly, although bone undergoes a decrease in the degree of mineralization with age, human dentin undergoes an increase [147][148][149]. The process begins in the third decade of life and is associated with a progressive filling of the dentin tubules with mineral until they become completely filled [10,140].…”