The histological effects of four endodontic sealers implanted in the oral mucosa: submucous injection versus implant in polyethylene tubes

Figueiredo, José Antônio Poli de; Pesce, Hildeberto Francisco; Gioso, Marco Antônio; Figueiredo, Maria Antonia Zancanaro de

doi:10.1046/j.1365-2591.2001.00407.x

Cited by 39 publications

(33 citation statements)

References 16 publications

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“…First, mucosal wound healing within the rabbit oral cavity is a well-established method for evaluating wound healing, [43][44][45][46][47] particularly when evaluating biomaterialguided wound healing. [48][49][50][51][52][53] Second, in the clinical setting, the presence of intraoral communication is significantly correlated to decreased bone graft survival time, 22 and thus an implant evaluation strategy that focuses on the closure of these communications is relevant for a situation where definitive repair will be performed using a standard or tissue- Table 1. Statistically significant differences ( p < 0.05) between groups, denoted by asterisk, were determined using pairwise Dwass-SteelCritchlow-Fligner tests for the implant interface scoring (A) and a Mann-Whitney U-test for the tissue response within pores (B).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Soft Tissue Coverage over Porous Polymethylmethacrylate Space Maintainers Within Nonhealing Alveolar Bone Defects

Kretlow

Shi

Young

et al. 2010

Tissue Engineering Part C: Methods

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Current treatment of traumatic craniofacial injuries often involves early free tissue transfer, even if the recipient site is contaminated or lacks soft tissue coverage. There are no current tissue engineering strategies to definitively regenerate tissues in such an environment at an early time point. For a tissue engineering approach to be employed in the treatment of such injuries, a two-stage approach could potentially be used. The present study describes methods for fabrication, characterization, and processing of porous polymethylmethacrylate (PMMA) space maintainers for temporary retention of space in bony craniofacial defects. Carboxymethylcellulose hydrogels were used as a porogen. Implants with controlled porosity and pore interconnectivity were fabricated by varying the ratio of hydrogel:polymer and the amount of carboxymethylcellulose within the hydrogel. The in vivo tissue response to the implants was observed by implanting solid, low-porosity, and high-porosity implants (n = 6) within a nonhealing rabbit mandibular defect that included an oral mucosal defect to allow open communication between the oral cavity and the mandibular defect. Oral mucosal wound healing was observed after 12 weeks and was complete in 3/6 defects filled with solid PMMA implants and 5/6 defects filled with either a low- or high-porosity PMMA implant. The tissue response around and within the pores of the two formulations of porous implants tested in vivo was characterized, with the low-porosity implants surrounded by a minimal but well-formed fibrous capsule in contrast to the high-porosity implants, which were surrounded and invaded by almost exclusively inflammatory tissue. On the basis of these results, PMMA implants with limited porosity hold promise for temporary implantation and space maintenance within clean/contaminated bone defects.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Soft Tissue Coverage over Porous Polymethylmethacrylate Space Maintainers Within Nonhealing Alveolar Bone Defects

Kretlow

Shi

Young

et al. 2010

Tissue Engineering Part C: Methods

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“…The criteria used to examine the results in the present study were two-fold because they allowed an objective analysis and a descriptive one (12,20). Because ''biocompatibility'' is defined by the capacity a material has of obtaining an appropriate biological response when applied to a body, the fact that a given material is biocompatible (or not) will depend on the physical function the material is expected to fulfill and also on the biological response one expects from it (26).…”

Section: Discussionmentioning

confidence: 99%

“…The slices were examined under a light microscope by one calibrated examiner. Slides were analyzed qualitatively according to the criteria described by Figueiredo et al (20). The cellular inflammatory component was determined by the presence of neutrophils, lymphocytes and plasmacytes, eosinophils, macrophages, and giant cells.…”

Section: Methodsmentioning

confidence: 99%

Mineral Trioxide Aggregate–based Sealer: Analysis of Tissue Reactions to a New Endodontic Material

Scarparo

Haddad

Acasigua

et al. 2010

Journal of Endodontics

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“…The cellular events were classified according to scores ( Table 1). The fibrous formation was classified according to estabilished scores [15] ( Table 2).…”

Section: Methodsmentioning

confidence: 99%

“…The abscess, characterized by the presence of degenerated neutrophils (piocites) in an area of the microscopy field, was also classified according to scores [15] (Table 3).…”

Section: Methodsmentioning

confidence: 99%

Biocompatibility of propolis in subcutaneous tissue of rats: a possible biomaterial for cavity cleansing

Almeida

Ferreira

Venâncio

et al. 2017

Rev. Odonto Ciênc. (Online)

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OBJECTIVE: The aim of this study was to histopathologically analyze, in subcutaneous connective tissue in rats, a propolis solution for cavity cleansing and its toxicity through hemolytic and Artemia franciscana tests. METHODS: Fifteen male rats were selected and randomly distributed in three experimental periods (07, 30 and 45 days), in which each animal received the four treatment groups in rounds: Group IPropolis I; Group II -Propolis II; Group III -Calcium Hydroxide Water and Group IV -2% Chlorexidine; the sides of the tube were the control group. The data were analyzed using descriptive statistics. The results showed, in terms of biocompatibility, that all materials presented a significant reduction of the inflammatory infiltrate and an increase of the thickness in the collagen fibers. It may be suggested, in decreasing order of biocompatibility, the use of following materials: calcium hydroxide-water, 2% chlorexidine, propolis I and propolis II. RESULTS: In the cytotoxicity test using A. franciscana, the propolis extract showed high toxicity when tested at concentrations and in the hemolytic activity test the propolis I extract showed greater activity than propolis II. CONCLUSION: The present study suggests the use of propolis as a cavity cleansing solution for shallow and medium cavities similar to 2% chlorexidine.Key words: Materials testing; Propolis; Dental cavity lining; Detergents Biocompatibilidade da própolis no tecido subcutâneo de ratos: um possível biomaterial de limpeza de cavidade RESUMO OBJETIVO: O objetivo deste estudo foi analisar histopatologicamente, em tecido conjuntivo subcutâneo de ratos, uma solução de própolis para a limpeza de cavidades e sua toxicidade através dos testes de hemólise e Artemia franciscana. METODOLOGIA: Foram utilizados 15 ratos machos, selecionados e distribuídos aleatoriamente em três grupos (n=5) em períodos experimentais (7, 30 e 45 dias), em que cada animal recebeu os quatro grupos de tratamento em forma de rodízio: Grupo I -Própolis I; Grupo II -Própolis II; Grupo III -Água de Hidróxido de Cálcio e Grupo IV -Clorexidina a 2%; as laterais do tubo foram o grupo controle. Os dados foram analisados pela estatística descritiva. RESULTADOS: Todos os materiais apresentaram uma redução significativa do infiltrado inflamatório e aumento da espessura das fibras colágenas. No teste de citotoxicidade de Artemia franciscana, o extrato de própolis apresentou alta toxicidade e no teste de atividade hemolítica o extrato de Própolis I mostrou-se mais ativo que o da Própolis II. CONCLUSÃO: O presente estudo mostrou a biocompatibilidade da própolis, sugerindo seu uso como solução de limpeza em cavidade cavidades rasas e médias semelhante à clorexidina a 2%.

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The histological effects of four endodontic sealers implanted in the oral mucosa: submucous injection versus implant in polyethylene tubes

Cited by 39 publications

References 16 publications

Evaluation of Soft Tissue Coverage over Porous Polymethylmethacrylate Space Maintainers Within Nonhealing Alveolar Bone Defects

Evaluation of Soft Tissue Coverage over Porous Polymethylmethacrylate Space Maintainers Within Nonhealing Alveolar Bone Defects

Mineral Trioxide Aggregate–based Sealer: Analysis of Tissue Reactions to a New Endodontic Material

Biocompatibility of propolis in subcutaneous tissue of rats: a possible biomaterial for cavity cleansing

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