The Histocompatibility (HLA) Antigen Distribution in Diabetes in Southern African Blacks (Xhosa)

Briggs, Brian R; Jackson, W. P. U.; DuToit, Ernette D; Botha, Martin C

doi:10.2337/diab.29.1.68

Cited by 32 publications

(16 citation statements)

References 3 publications

(3 reference statements)

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“…Both the Natal group, and Shires et al (1983) in the Transvaal, found increased frequencies of B8 whereas our patients had a non-significantly decreased B8 frequency. Previously, increases in A2 and B35 have been reported in Black patients from the Cape (Briggs et al 1980) but we have been unable to confirm this. We cannot explain why Black patients from other parts of South Africa have certain MHC associations not present in patients from the Cape.…”

Section: Discussioncontrasting

confidence: 86%

“…Associations of certain HLA antigens with insulin dependent diabetes mellitus (IDDM) are well documented in people of various ethnic origins (Christy et al 1979, Svejgaard et al 1980 including Caucasoids, Orientals (Wakisaka et al 1976, Maeda et al 1980, Lee et al 1983 and American Blacks ). There have recently been reports of similar studies in South African Blacks (Briggs et al 1980, Shires et al 1983, Omar et al 1984a).…”

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confidence: 88%

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HLA‐A, B, C and DR antigen associations in insulin dependent diabetes mellitus (IDDM) in South African Negro (Black) and Cape Coloured people

Orren

Taljaard²,

Toit³

1985

Tissue Antigens

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HLAA, B, C and DR antigen frequencies were determined in South African Negro (Black) (50) and Cape Coloured (57) patients with insulin dependent diabetes mellitus (IDDM) and in appropriate controls. The Black patients failed to show associations commonly reported for American Black patients with IDDM but did show a weakly significant increase in the DRw9 frequency. However, this antigen was rare even in the patient group and HLA associated genes do not appear to play a major role in the pathogenesis of IDDM in these people. The Cape Coloureds have a high proportion of Caucasoid genes. Coloured IDDM patients had the expected low DR2 and high DR4 frequencies. Unexpectedly the Cape Coloureds failed to show significant associations of IDDM with B8 or DR3.

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Section: Discussioncontrasting

confidence: 86%

mentioning

confidence: 88%

HLA‐A, B, C and DR antigen associations in insulin dependent diabetes mellitus (IDDM) in South African Negro (Black) and Cape Coloured people

Orren

Taljaard²,

Toit³

1985

Tissue Antigens

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“…Thus, a lot of studies are performed in order to find new associations with diseases. This is the case for studies carried out in eastern (Bodner et al, 1975;Hall et al, 1982), western (Famuyiwa et al, 1982), and southern Africa (Briggs et al, 1980;Hammond et al, 1977Hammond et al, , 1980. In spite of the different aims pursued in such studies, they are interesting for us in that they contribute to the elucidation of the question of whether the HLA system is selected or not.…”

Section: Methodological Problemsmentioning

confidence: 99%

Genetics and history of sub-Saharan Africa

Excoffier

Pellegrini

Sanchez‐Mazas

et al. 1987

Am. J. Phys. Anthropol.

101

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This paper aims to review the contribution of genetic data to the prehistory and history of sub‐Saharan African peoples. The authors review briefly paleontologic data, which give limited information about modern Homo sapiens sapiens origins and isolation of present African gene pools. Most linguistic and archaeological theories about African peoples' prehistory are then confronted with the most informative genetic data available. Rhesus, Gm, HLA, and DNA data are analyzed. Their frequent haplotypes are compared between populations by means of genetic distances and average linkage clustering. Despite heterogeneities between the quality and the quantity of data provided by different genetic systems, some clear conclusions can be drawn. Genetic differentiation clearly parallels the clustering of major linguistic families. These families of populations seem genetically homogeneous, suggesting either relatively recent origins or long‐term important and continuous intragroup migrations. The well‐known divergence between the historical theories suggested by immunological and DNA data about the relationship between Africa and other gene pools is discussed. Decisive conclusions about African origins of modern humans either from fossil or from DNA data seem very premature. An alternative hypothesis issued from overall genetic variation is proposed.

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“…Evidence for a gene-conferring susceptibility to type I1 diabetes has also been found in two other populations. Type I1 diabetes is associated with HLA-A2 in the Xhosa, a southern African black population (Briggs et al, 1980) and with HLA-Bw61 in Fiji Indians (Sarjeantson et al, 1981).…”

Section: Familial Nature Of Diabetes In the Pimasmentioning

confidence: 98%

Diabetes mellitus in the Pima Indians: Genetic and evolutionary considerations

Knowler

Pettitt

Bennett

et al. 1983

American J Phys Anthropol

118

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Non-insulin-dependent diabetes mellitus is a common disease in the Pima Indians. It is familial and strongly related to obesity. Neel (1962) suggested that the introduction of a steady food supply to people who have evolved a "thrifty genotype" leads to obesity, insulin resistance, and diabetes. Our findings in the Pimas of differences in insulin sensitivity in different metabolic pathways suggest that the thrifty genotype involves the ability of insulin to maintain fat stores despite resistance to glucose disposal. The recent increase in diabetes incidence following the availability of an abundant food supply suggests that the ability to store energy efficiently during cycles of feast and famine may now lead to obesity, insulin resistance, and diabetes.

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The Histocompatibility (HLA) Antigen Distribution in Diabetes in Southern African Blacks (Xhosa)

Cited by 32 publications

References 3 publications

HLA‐A, B, C and DR antigen associations in insulin dependent diabetes mellitus (IDDM) in South African Negro (Black) and Cape Coloured people

HLA‐A, B, C and DR antigen associations in insulin dependent diabetes mellitus (IDDM) in South African Negro (Black) and Cape Coloured people

Genetics and history of sub-Saharan Africa

Diabetes mellitus in the Pima Indians: Genetic and evolutionary considerations

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