HLA‐A, B, C and DR antigen associations in insulin dependent diabetes mellitus (IDDM) in South African Negro (Black) and Cape Coloured people

Orren, Ann; Taljaard, D. G.; Toit, E. D. du

doi:10.1111/j.1399-0039.1985.tb02232.x

Cited by 25 publications

(4 citation statements)

References 23 publications

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“…Similar associations of IDDM susceptibility with DRB1*03 and DRB1*04 have been observed in southern African populations (Table 2) – DRB1*03 in the Zulu (5), Shona (20) and SA Indian population (21); DRB1*04 in the Zulu (22) and SA Indians of North Indian descent (21) and DRB1*03/*04 heterozygosity in the Zulu and SA Indian population (21, 22). In contrast, the SA Coloreds showed no significant association between HLA DRB1*03 and IDDM (23). Xhosa patients with IDDM showed a unique DRB1*14011 susceptibility association (22), whereas a study on the Zulu population showed various susceptibility associations, of which HLA‐DRB1*09 was most significant (5).…”

Section: Hla Class II Diversity and Disease Susceptibility Of Southermentioning

confidence: 99%

“…Whereas DRB1*15, DQB1*0602, DQB1*0301, and DQA1*0102 conferred protection from IDDM in most other populations (24), it was found that DRB1*0302 and DQA1*04 were negatively associated with IDDM in Zulus (5). Similarly, DRB1*11 and DR2 were observed to be associated with IDDM resistance in the Shona (20) and the SA Coloreds, respectively (23)…”

Section: Hla Class II Diversity and Disease Susceptibility Of Southermentioning

confidence: 99%

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HLA class II disease associations in southern Africa

et al. 2006

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Southern Africa harbors several population groups representing a diversity of gene pool origins. This provides a unique opportunity to study genetic disease predisposition in these populations against a common environmental background. Human leukocyte antigen (HLA) association studies of these populations could improve knowledge on inter-population variation and HLA-related disease susceptibility. The aim of this paper is to review HLA class II disease associations reported for southern African population groups, compare them with findings in other populations and identify those unique to southern Africa. A number of HLA class II disease associations appear to be unique to southern African populations. These include DRB1*14011 association with insulin-dependent diabetes mellitus susceptibility in the Xhosa and DRB1*10 and DQB1*0302 with rheumatoid arthritis susceptibility in the South African (SA) Indian and SA Coloreds, respectively. A noteworthy similarity in class II disease association was observed among southern African Caucasoid and their European parental populations. Unique HLA class II disease associations observed in southern Africa are consistent with the notion that unique environmental and natural selective factors have resulted in certain ethnic-specific HLA class II disease associations, while common HLA class II disease associations found across different populations support the notion that common diseases are caused by common, ancient alleles present in indigenous African populations.

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Section: Hla Class II Diversity and Disease Susceptibility Of Southermentioning

confidence: 99%

Section: Hla Class II Diversity and Disease Susceptibility Of Southermentioning

confidence: 99%

HLA class II disease associations in southern Africa

et al. 2006

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“…Occasionally, associations between IDDM and DRnon3non4 antigens have been described (e.g. Orren et al 1985, B e r t r a m & Baur 1984), or in some instances no associations were found (Mac-Donald et al 1986).…”

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confidence: 99%

HLA‐DR and DQ antigens in insulin‐dependent diabetics in Ethiopia

et al. 1987

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Thirty‐one Ethiopian insulin‐dependent (or type I) diabetes mellitus (IDDM) patients and thirty‐three healthy controls from the same ethnic background were typed for HLA‐A, B, C, DR and DQ specificities. The frequencies of both DR3 and DR4 were significantly increased among IDDM patients (resp. p = 0.02, p = 0.01), confirming results in other populations. In contrast to observations in Caucasians, no significant negative association was found with TA10, a newly recognized DQ specificity, at least in the population studied here, whereas DQw1 was more frequently observed among healthy controls (p = 0.01). Although this latter difference does not retain statistical significance after correction for the number of comparisons made, these findings may support previous results suggesting the existence of IDDM susceptibility genes associated with DR3 and DR4 and of IDDM resistance genes associated with DQ antigens.

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“…The coloured patients failed to show an association with B8 and DR3, but did have an increased frequency of DR4 and a decreased frequency of DR2, commonly seen in Caucasian populations. 66 The latest South African study reported in the literature was published in 2001. In this study, Zulu diabetics [typed by polymerase chain reaction (PCR) with sequence-specific primers] showed the presence of the common susceptibility antigens: DR3, DR4, DQ2 and DR9.…”

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confidence: 99%

The epidemiology and pathogenesis of type 1 diabetes mellitus in Africa

Padoa

2011

Journal of Endocrinology, Metabolism and Diabetes of South Afri

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Type 1 diabetes is a serious, debilitating disease, with life-threatening complications, and the financial burden associated with the management of this disease is enormous. Early diagnosis and intervention can improve morbidity and mortality. Unfortunately, in Africa, type 1 diabetes is poorly characterised, and there is sparse information regarding the aetiology and epidemiology of this disease. However, there is some evidence of a later age of onset in African type 1 diabetic patients, compared to European diabetics, and it is thought that the prevalence of type 1 diabetes is lower in African populations than in the Western world.

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HLA‐A, B, C and DR antigen associations in insulin dependent diabetes mellitus (IDDM) in South African Negro (Black) and Cape Coloured people

Cited by 25 publications

References 23 publications

HLA class II disease associations in southern Africa

HLA class II disease associations in southern Africa

HLA‐DR and DQ antigens in insulin‐dependent diabetics in Ethiopia

The epidemiology and pathogenesis of type 1 diabetes mellitus in Africa

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