HLA‐DR and DQ antigens in insulin‐dependent diabetics in Ethiopia

Abstract

Thirty‐one Ethiopian insulin‐dependent (or type I) diabetes mellitus (IDDM) patients and thirty‐three healthy controls from the same ethnic background were typed for HLA‐A, B, C, DR and DQ specificities. The frequencies of both DR3 and DR4 were significantly increased among IDDM patients (resp. p = 0.02, p = 0.01), confirming results in other populations. In contrast to observations in Caucasians, no significant negative association was found with TA10, a newly recognized DQ specificity, at least in the population studied here, whereas DQw1 was more frequently observed among healthy controls (p = 0.01). Although this latter difference does not retain statistical significance after correction for the number of comparisons made, these findings may support previous results suggesting the existence of IDDM susceptibility genes associated with DR3 and DR4 and of IDDM resistance genes associated with DQ antigens.

HLA class II allele and haplotype frequencies in Ethiopian Amhara and Oromo populations

“…It can therefore be concluded that these data are consistent with HardyWeinberg equilibrium, which can not thus be rejected. The present results are in agreement with those obtained by Ottenhoff et al (6) in thirty-three healthy controls selected in the Amhara ethnic group, analysed by serological methods. It is interesting to emphasise the frequent occurrence of DRB1*07 followed by DRB1*13 in both groups.…”

“…Furthermore, these studies essentially contained serological data whose interpretation is limited by the use of antisera chosen most of the time in a panel of Caucasoid donors. In the Amhara group, Ottenhoff et al (6) reported serological analysis of HLA class II antigens obtained from a small number of IDDM patients and ethnically matched controls. Molecular analysis proved to be a powerful method for precisely defining HLA class II alleles, and the polymorphism of these genes, as revealed by genotyping, appeared much more complex than that defined by conventional serological methods (7).…”

Association of HLA-DRB1/DQB1 Alleles and Genetic Susceptibility to Type 1 Diabetes Mellitus

“…The allele B*39:06 (OR =10.31; 95% CI, 4.21-25.1) confers the greatest vulnerability outside of the class II area. Ottenho (26) demonstrated that IDDM patients had considerably higher frequencies of both DR3 and DR4 (respectively, p-value= 0.02, p-value= 0.01). A high-risk HLA-DR4/DQ8 haplotype is associated with a higher incidence of T1D in that group, According to Duarte et al (27) studies, the high-risk HLA-DR4/DQ8 haplotype is linked to a higher incidence of T1D in her group.…”

Prognostic Role of Human Leukocyte Antigen Alleles and Cytokine Single-Nucleotide Polymorphisms in Patients with Chronic Myeloid Leukemia Treated with Tyrosine Kinase Inhibitor Drugs

“…Studies on HLA frequencies for the African population are scarce, with limited and outdated references, particularly for the Ethiopian population, often relying on now obsolete methods [ 36 , 37 , 38 ]. Only a few African studies, such as Abshir et al, reported high-resolution HLA data from Somalia [ 39 ].…”