This is a study of 1,001 male and female Mexican migrant farmworkers, ages 18 to 59, in rural central California. The Center for Epidemiological Studies–Depression (CES‐D) scale was used to measure prevalence of depressive symptomatology and its distribution on demographic, social support, acculturation, and acculturation stress variables. CES‐D caseness rates (≥ 16) were 21.1% for men and 19.7% for women. Logistic regression showed significant risk increments among respondents with high levels of acculturation (adjusted OR = 6.2) and stress due to discrimination (adjusted OR = 2.4). © 1999 John Wiley & Sons, Inc.