The hippocampal formation as a source of the slow endogenous potentials

Okada, Yoshio; Kaufman, Lloyd; Williamson, Samuel J.

doi:10.1016/0013-4694(83)90130-x

Cited by 279 publications

(71 citation statements)

References 11 publications

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“…Our recent study reported that a reduced P300 amplitude is associated with volume reduction of the left medial temporal lobe in schizophrenia (Kawasaki 1997), and many reports suggest that part of P300 recorded on the scalp generates from the medial temporal lobe (Okada, 1983). The present study could not determine which region of the temporal lobe, however, becomes a pathologic focus for P300 and neuropsychological abnormalities in schizophrenia.…”

Section: Discussioncontrasting

confidence: 63%

The relationship between auditory ERP and neuropsychological assessments in schizophrenia☆

Nagasawa¹,

Kamiya²,

Kawasaki³

et al. 1999

International Journal of Psychophysiology

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To clarify the cognitive significance of event-related potential (ERP) abnormalities in schizophrenia, we examined the relationships of amplitudes and latencies of ERP components with performance on neuropsyhological tests in schizophrenic patients. Twenty patients underwent the Trail Making B Test (TM-B), which is sensitive to frontal lobe dysfunction, and the logical memory, verbal paired-association, and visual reproduction subtests of the Wechsler Memory Scale (WMS), which are sensitive to temporal lobe dysfunctions, and ERP recordings during performance of an oddball auditory discrimination task. Pearson product-moment correlations indicated that an increased P200 amplitude was correlated with poor performance on the TM-B, whereas a decreased P300 amplitude was correlated with poor performance on the verbal paired-association subtest of the WMS. These findings suggest that a P200 abnormality represents the frontal lobe dysfunction, and a P300 abnormality represents the left temporal lobe dysfunction in schizophrenia.

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Section: Discussioncontrasting

confidence: 63%

The relationship between auditory ERP and neuropsychological assessments in schizophrenia☆

Nagasawa¹,

Kamiya²,

Kawasaki³

et al. 1999

International Journal of Psychophysiology

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“…Magnetoencephalographic recordings in normal subjects have been interpreted to confirm the idea that P3 is generated in the hippocampus (Okada, Kaufman, and Williamson, 1983). In this study, the magnetic field measured using a single sensor moved to various locatiohs around the head showed an event-related response presumed to correspond to the electrical P3.…”

supporting

confidence: 52%

The Neural Substrates of Cognitive Event-Related Potentials: A Review of Animal Models of P3

Paller¹

1994

Cognitive Electrophysiology

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O~e reaso.n to study the electrical activity of the brain is that the knowledge game.d might be useful for understanding the neural basis of cognitive functlOns. I~other words, endogenous or cognitive event-related potentials (~RPs), which are. averaged field potentials that are sensitive to manipulahons of psychological variables, could provide evidence to constrain theories on the brain mechanisms that mediate cognition. The success of this approach, however, depends on the extent to which two types of relationships can be s~bsta~tiated: relationships between ERPs and theories of cognition and relatlOnshlps between ERPs and particular neural events, structures, or ystems. Alth~~gh cognitive ERPs have been thoroughly characterized only m humans, cnhcal evidence for clarifying the neurophysiological substrates of cognitive ERPs may come from studies in animals (Galambos and Hillyard, 1981~. This review focuses on recent studies that have begun to develop ammal models of a particularly well-characterized cognitive E~P, the P3 or P300 potential. To develop criteria for assessing these ammal models, the characteristics of P3 in humans are first outlined. Evidence pertaining to the adequacy of each of the putative animal models is then discussed by species, along with evidence about the neural basis of th:se ERPs. The concluding section will reflect on prospects for understandmg the neural basis of P3 and on the usefulness of the animal approach..Cognitive Electrophysiology

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“…Although the neurophysiology underlying the P300 is still being explored (Halgren et al , 1980;Okada et al, 1983), the cognitive events associated with its generation have received considerable attention (Donchin, 1981;Pritchard, 1981). Because the P300 component is thought to reflect the cognitive events of stimulus classification, its latency has been used to evaluate mental function in normal aging (Brown et al ., 1983;Ford et al , 1982;Goodin et al , 1978;Pfefferbaum et al , I 984a;Picton et al, 1984;Smith et al , 1980;Syndulko et al , 1982) and in patients with neurological and psychiatric disorders (Brown et al , 1982;Goodin et al, 1978;Hansch et al , 1982;Pfefferbaum et al , l 984b;Squires et al, 1980).…”

mentioning

confidence: 99%

Effects of Age on the P300 Component of the Event-related Potential From Auditory Stimuli: Peak Definition, Variation, and Measurement

Polich

Howard

Starr

1985

Journal of Gerontology

182

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An auditory " oddball" paradigm was used to elicit the P300 component or the event-related brain potential (ERP) from a large sample of young (5 to 15 years) and older (20 to 86 years) persons. Distinct Pla and P3b subcomponents or the P300 were observed within individuals and across trial blocks. Age affected P300 latency in a similar fashion for both subcomponents with latency increasing about 65 msec between 20 and 70 years. P300 latency variability also was found to increase somewhat with advanced age. These results confinned previous age-related ERP changes and extended them to the P3a and P3b subcomponents.

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The hippocampal formation as a source of the slow endogenous potentials

Cited by 279 publications

References 11 publications

The relationship between auditory ERP and neuropsychological assessments in schizophrenia☆

The relationship between auditory ERP and neuropsychological assessments in schizophrenia☆

The Neural Substrates of Cognitive Event-Related Potentials: A Review of Animal Models of P3

Effects of Age on the P300 Component of the Event-related Potential From Auditory Stimuli: Peak Definition, Variation, and Measurement

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