The High-Sensitivity C-Reactive Protein Level One Month After Bare-Metal Coronary Stenting May Predict Late Adverse Events

Interleukin‐6, but Not C‐Reactive Protein, Predicts the Occurrence of Cardiovascular Events after Drug‐Eluting Stent for Unstable Angina

“…More importantly, the elevated concentrations of inflammatory cytokines normalize within a couple of weeks,27,34,35 and their impact on the clinical outcome is yet unclear. Previous studies21,[3][4][5][6][7][8][9][11][12][13][14]22,27,29,30,31,34,35 did not find hs-CRP to be a predictor of ST, a finding replicated by our study as well.reliable biomarker for the prediction of late-occurring definite or probable ST because early ST is generally related to the procedure itself. So, in the light of the results by Hwang et al,…”

“…Among the inflammatory biomarkers implicated in ST after DES, hs-CRP is the most extensively studied. [3][4][5][6][7][8][9][10] Unfortunately, data regarding the prediction of hs-CRP levels for CV after DES are conflicting: some studies [5][6][7][8][9][10][11][12] reported that high hs-CRP levels correlated with ST, but some investigators failed to agree. 10,13,14 The principal reason for the conflicting results appears to be the timing of statin treatment and hs-CRP measurement not being precisely defined.…”

“…10,13,14 The principal reason for the conflicting results appears to be the timing of statin treatment and hs-CRP measurement not being precisely defined. [6][7][8][9][10][11][12][13][14] Statins exhibit well-known anti-inflammatory properties 15 ; their beneficial effects in patients undergoing stent deployment have been documented in many clinical studies. [16][17][18] Thus, the real meaning of "baseline hs-CRP levels" as reported in previous studies has been recently challenged.…”

Genetic Determined Low Response to Thienopyridines is Associated with Higher Systemic Inflammation in Smokers

“…Additionally, the ability of clopidogrel and prasugrel in the reduction of inflammation would be particularly important in the clinical setting since it has been demonstrated that post-PCI inflammatory response is the primary causative mechanism of ISR [8,9,18], and that elevated inflammatory markers, particularly CRP [19], is associated with an increased incidence of adverse cardiac events in post-PCI patients [20]. For instance, it has been demonstrated that CRP values >2.5 mg/l at 30 days after PCI is associated with long term (at 12 month) adverse clinical events, particularly ISR [21]. However, considerable controversy has surrounded the effects of antiplatelet drugs on the level of inflammatory markers [16].…”

Is C-reactive protein a prognostic marker after angioplasty?

“…The results of this study showed that elevated preprocedural levels of CRP indicated an increased risk of death and combined death/myocardial infarction after ULMCA stenting. More recently, Fournier et al 8 examined whether hsCRP levels may predict late adverse events, 1 month after bare-metal coronary stenting. The 12-month event-free survival rate was greater when the hs-CRP levels at 30 days were equal to or less than 2.5 mg/l.…”