Genetic Determined Low Response to Thienopyridines is Associated with Higher Systemic Inflammation in Smokers

Shahabi, Payman; Cuisset, Thomas; Stathopoulou, Maria G.; Morange, Pierre‐Emmanuel; Grosdidier, Charlotte; Herbeth, Bernard; Siest, Gérard; Alessi, Marie‐Christine; Visvikis‐Siest, Sophie

doi:10.2217/pgs.15.17

Cited by 2 publications

(3 citation statements)

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“…Comparison of CRP with smoking behaviour showed no significant relation (P=0.541; Table 3) in contrast to Shahabi et al 6 study, which demonstrates significant relationship of CRP levels and smoking (P=0.001). The difference could be attributed to a separate grouping of "former smokers."…”

Section: Discussioncontrasting

confidence: 60%

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C-reactive Protein in Periodontitis and its Comparison with Body Mass Index and Smoking Behaviour

Gupta

Pradhan

et al. 2017

J Nepal Med Assoc

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Introduction: Chronic periodontitis is an infectious disease resulting in inflammation within the supporting tissues of the teeth, progressive attachment loss, and bone loss. In addition to declining oral health, there is always low grade infection present in periodontitis. Studies show increased levels of systemic biomarkers in periodontal disease such as CRP, which is considered a key-marker of CVD. Research has also shown positive association between BMI and smoking with periodontitis and CRP. The objective of the study was to assess the levels of CRP in patients with and without periodontitis and their relation with BMI and smoking behaviour.Methods: Patients visiting the Dental department of Bir Hospital were invited to participate in the study. Total 31 subjects in each group: Case (periodontitis) and Control (without periodontitis) were selected using convenience sampling technique. All subjects underwent periodontal examination by a single examiner. Serum CRP samples were taken before periodontal treatment. Data analysis was done by SPSS 17 software program.Results: Increase in mean CRP levels in periodontitis (5.8595mg/L) with high statistical significance (p=0.000) in comparison to subjects without periodontitis (1.1214mg/L) was observed. BMI showed positive association with periodontitis (p=0.046) but not with CRP (0.213). Smoking behaviour showed no significant relation with either CRP (p=0.344) or periodontitis (p=0.541).Conclusions: We found highly significant association between periodontitis and CRP levels but not always with BMI and smoking. CRP, which is an established marker for CVD was significantly increased in periodontal infections. Hence, a close interaction among Physician, Periodontist and Patient to prevent adverse health situations is recommended.Keywords: body mass index; cardiovascular disease; c-reactive protein; periodontitis; smoking; systemic inflammation. [PubMed]

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Section: Discussioncontrasting

confidence: 60%

“…4 Smoking is another variable strongly related to both CVD as well as chronic periodontitis (CP). 5,6 CP and body mass index (BMI) are jointly associated with increase in CRP levels in otherwise healthy adults. 7 When compared with unaffected control populations, patients with periodontitis have increased serum levels of CRP.…”

Section: Introductionmentioning

confidence: 99%

C-reactive Protein in Periodontitis and its Comparison with Body Mass Index and Smoking Behaviour

Gupta

Pradhan

et al. 2017

J Nepal Med Assoc

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“…It is then important to check the potential interaction between clopidogrel and inflammatory process [4]. In addition, these CYPs are highly inducible by drugs and environmental compounds after their binding to nuclear receptors [5].…”

Section: Cyp2c and Epoxyygenasesmentioning

confidence: 99%

CYP 2C19 and UDP-glucuronosyltransferases not only for drugs but also for endobiotics

Siest¹,

Fournel‐Gigleux

Magdalou

2014

Drug Metabolism and Drug Interactions

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Genetic Determined Low Response to Thienopyridines is Associated with Higher Systemic Inflammation in Smokers

Abstract: Interaction between CYP2C19 polymorphisms and smoking modifies on-treatment CRP level of post-stenting, on-thienopyridine patients. This effect seems to be independent to the level of P2Y12 receptor inhibition.

Cited by 2 publications

References 38 publications

C-reactive Protein in Periodontitis and its Comparison with Body Mass Index and Smoking Behaviour

C-reactive Protein in Periodontitis and its Comparison with Body Mass Index and Smoking Behaviour

CYP 2C19 and UDP-glucuronosyltransferases not only for drugs but also for endobiotics

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