The high prognostic value of the histologic grade at the deep invasive front of tongue squamous cell carcinoma

Kurokawa, Hideo; Zhang, M.; Matsumoto, Shinobu; Yamashita, Yuichi; Tomoyose, Taiki; Tanaka, Terumasa; Fukuyama, Hiroshi; Takahashi, Tsuneo

doi:10.1111/j.1600-0714.2005.00244.x

Cited by 90 publications

(86 citation statements)

References 39 publications

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“…The considerable variation in the histological aspect of this condition led to the development of a number of systems for the histological grading of malignancy. These systems were designed to allow for an interpretation of the aggressiveness of the tumor (1). In 1920, Broders (2) used cell pleomorphism and keratin production as parameters for the assessment of cell differentiation and the number of mitoses for the assessment of tumor growth.…”

Section: Introductionmentioning

confidence: 99%

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Role of inflammation in oral carcinogenesis (Part I): Histological grading of malignancy using a binary system

Piva¹,

Souza²,

Martins-Filho³

et al. 2011

Oncology Letters

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Abstract. The aim of the present study was to assess the suppressant role of the inflammatory infiltrate in oral carcinogenesis through the immunohistochemical expression of CD8 and FOXP3 and to discuss how representative this expression proved, as well as other parameters considered to be of prognostic value. A total of 20 cases of oral epithelial dysplasia and 40 cases of oral squamous cell carcinoma were selected. The criteria suggested by the World Health Organization were used for the histological grading of dysplasia. For carcinoma, a binary method was developed for the present study using parameters such as type of invasion, maturity, presence of epithelial masses and dysmorphism of the masses. Immunohistochemical analysis was performed for assessment of the expression of anti-CD8 and anti-FOXP3 in cases of dysplasia and carcinoma. Although the inflammatory infiltrate was more intense in the majority of carcinomas, it exercised a protective role in the dysplasia cases, as CD8 expression was significantly greater. Although a correlation was found between CD8 and the intensity of the inflammatory infiltrate in the carcinoma cases, CD8 demonstrated >5% expression in only 32.5% of the cases, compared to 80% of the dysplasia cases. Thus, we suggest that the inflammatory infiltrate should not be used as a parameter in routine examinations, as it plays different roles in the various stages of carcinogenesis. The histological grading system for malignancy employed in the present study is indicated for the assessment of oral squamous cell carcinoma.

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Section: Introductionmentioning

confidence: 99%

“…Kurokawa et al (1) studied the relationship between the scores obtained using Bryne's method and the prognosis of patients with squamous cell carcinoma of the tongue. Results showed that patients with a score below 8 had a more positive prognosis, whereas those with a score of 11 or higher had a poorer prognosis.…”

Section: Introductionmentioning

confidence: 99%

Role of inflammation in oral carcinogenesis (Part I): Histological grading of malignancy using a binary system

Piva¹,

Souza²,

Martins-Filho³

et al. 2011

Oncology Letters

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“…The most promising factor emerging from these studies seemed to be the depth of tumor infiltration. [14][15][16][20][21][22][23][24][25][26][27][28][29][30][31][32][33] Even nowadays, many centers still rely on cutoff values of 4 or 5 mm of tumor depth for indication of elective neck treatment. With regard to the much more focused and precise histological staging of sentinel lymph nodes in contrast to nodes in neck dissection specimens, the aim of this study was to assess whether any of the formerly evaluated clinical or histologic factors in the primary tumors were still significantly predictive of occult disease in the context of SNB.…”

mentioning

confidence: 99%

Evaluation of Clinical and Histomorphological Parameters as Potential Predictors of Occult Metastases in Sentinel Lymph Nodes of Early Squamous Cell Carcinoma of the Oral Cavity

2009

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Background. Sentinel node biopsy (SNB) for cN0 early squamous cell carcinoma (SCC) of the oral cavity has been validated by numerous studies. Around 30% of SNB will detect occult disease. Several clinical and morphological features of the primary tumor have been claimed to be predictive for occult metastasis in elective neck dissections. The aim of this study was to assess these factors in the context of SNB. Methods. Seventy-eight patients undergoing SNB for T 1/2 oral SCC from the years 2000 to 2007 were prospectively included. Primary tumors were reviewed for the following morphological and clinical parameters: grade of differentiation, tumor depth, tumor thickness, perineural invasion, lymphatic invasion, vascular invasion, muscle invasion, lymphoplasmacytic infiltration, and mode of invasion, age, gender, primary tumor site, tumor side, and cT category. Results. Statistical analysis revealed significance to predict occult metastasis in the SNB for grade of differentiation (P = 0.002), lymphatic invasion (P \ 0.001), and mode of invasion (P \ 0.001). None of the other factors reached significance. The mean tumor depth was 6.45 mm (range 0.72-15.15 mm) and the mean tumor thickness was 7.2 mm (range 0.72-15.15 mm). None of the cutoff values reached significance for predicting occult disease. Conclusions. Tumor depth and tumor thickness failed to achieve statistical significance for prediction of occult metastases in the context of SNB. Patients with cN0 early squamous cell carcinoma of the oral cavity should be offered SNB regardless of their tumor depth and thickness. Poorly differentiated carcinomas, carcinomas with lymphangiosis, and carcinomas with a dissolute mode of invasion show a high probability of positive SNB. Lymph node metastases have been shown to be the strongest prognosticator in head and neck squamous cell carcinoma (HNSCC). The 5-year survival drops considerably from 63-86% in patients with no nodal involvement to 20-36% in patients with lymph node metastases. [1][2][3][4] Whereas therapeutic neck dissection in patients with overt lymph node involvement is considered standard of care, there still exists controversy with regard to elective treatment of the clinically negative neck. Though the benefit of elective neck dissection versus wait-and-see with therapeutic neck dissection in case of nodal relapse has never been proven in large randomized trials, most centers around the world favor an active policy in these situations. The rationale for this lies in the high prevalence of occult disease found on routine elective neck dissection. However, although 20-30% of clinically N0 patients will show occult metastases on elective neck dissection, a considerably large number of patients will remain pathologically N0, and therefore do not benefit from the surgical intervention. 5,6 During the last decade sentinel node biopsy (SNB) has been adopted from the treatment of breast cancer and melanoma, and successfully introduced in the treatment regimen of early oral and oropharyngeal squamous cel...

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“…El hallazgo de cáncer en los ganglios es el factor de riesgo para recurrencia, ya que disminuye la sobrevida de 50% a 15-30% en un periodo de 5 años (6). Varios estudios coinciden en que el hallazgo de cáncer en los ganglios regionales es el factor de riesgo para recurrencia (3)(4)(5)(6). Una serie grande publicada por Lam, con más de 600 sujetos con diagnóstico de cáncer de lengua, acumulados en 24 años, muestra que factores como: la presencia de ganglios cervicales comprometidos, la localización del cáncer en la base de la lengua y la edad avanzada, están relacionados con una menor tasa de sobrevida.…”

Section: Importancia De La Detección Temprana De Cáncerunclassified

Importancia de la detección temprana de cáncer.

Zárate¹

2012

Rev Med Hered

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The high prognostic value of the histologic grade at the deep invasive front of tongue squamous cell carcinoma

Abstract: This study found that a high IFG malignancy score had a high prognostic value for squamous cell carcinoma of the tongue.

Cited by 90 publications

References 39 publications

Role of inflammation in oral carcinogenesis (Part I): Histological grading of malignancy using a binary system

Role of inflammation in oral carcinogenesis (Part I): Histological grading of malignancy using a binary system

Evaluation of Clinical and Histomorphological Parameters as Potential Predictors of Occult Metastases in Sentinel Lymph Nodes of Early Squamous Cell Carcinoma of the Oral Cavity

Importancia de la detección temprana de cáncer.

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