The high diversity of arsenolipids in herring fillet (Clupea harengus)

Lischka, Susanne; Arroyo‐Abad, Uriel; Mattusch, Jürgen; Kuhn, Alexandra; Piechotta, Ch.

doi:10.1016/j.talanta.2013.02.051

Cited by 63 publications

(67 citation statements)

References 38 publications

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“…In bivalve molluscs, which have complex As speciation, AB can be a significant portion of water soluble As (Francesconi and Edmonds 1997, Moreda-Piñeiro et al 2010, Berges-Tiznado et al 2013), whereas in cephalopods (Suner et al 2002) and crustaceans, which have much simpler As speciation, AB is the dominant species (Francesconi and Edmonds 1997, Hunter et al 1998, Francesconi et al 1999, Li et al 2003). In finfish As is also predominantly AB, although AsLipids can be a significant fraction in some oily fish (Taleshi et al 2010, Lischka et al 2013). …”

Section: Sources and Distribution Of Organic As Species In Marine mentioning

confidence: 99%

Human exposure to organic arsenic species from seafood

Taylor

Goodale

Raab

et al. 2017

Science of The Total Environment

379

256

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Seafood, including finfish, shellfish, and seaweed, is the largest contributor to arsenic (As) exposure in many human populations. In contrast to the predominance of inorganic As in water and many terrestrial foods, As in marine-derived foods is present primarily in the form of organic compounds. To date, human exposure and toxicological assessments have focused on inorganic As, while organic As has generally been considered to be non-toxic. However, the high concentrations of organic As in seafood, as well as the often complex As speciation, can lead to complications in assessing As exposure from diet. In this report, we evaluate the presence and distribution of organic As species in seafood, and combined with consumption data, address the current capabilities and needs for determining human exposure to these compounds. The analytical approaches and shortcomings for assessing these compounds are reviewed, with a focus on the best practices for characterization and quantitation. Metabolic pathways and toxicology of two important classes of organic arsenicals, arsenolipids and arsenosugars, are examined, as well as individual variability in absorption of these compounds. Although determining health outcomes or assessing a need for regulatory policies for organic As exposure is premature, the extensive consumption of seafood globally, along with the preliminary toxicological profiles of these compounds and their confounding effect on assessing exposure to inorganic As, suggests further investigations and process-level studies on organic As are needed to fill the current gaps in knowledge.

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Section: Sources and Distribution Of Organic As Species In Marine mentioning

confidence: 99%

Human exposure to organic arsenic species from seafood

Taylor

Goodale

Raab

et al. 2017

Science of The Total Environment

379

256

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show abstract

“…The lipid-soluble arsenic species is a group of compounds also referred to as arsenolipids, and these compounds are major arsenic species present in the lipid or oily fractions of marine organisms [7]. Four groups of arsenolipids (Table 1) have so far been identified in marine samples; the arsenosugar-phospholipids (As-sugPLs) [11][12][13], the arseniccontaining hydrocarbons (AsHCs) [12][13][14][15], the arsenic-containing fatty acids (AsFAs) [13,[16][17][18][19][20] and the cationic trimethylarsenio fatty alcohols (TMFAsOHs) [15].…”

Section: Acronymsmentioning

confidence: 99%

“…Although over 40 species of arsenolipids have been identified in marine samples [11][12][13][15][16][17][18][19][20] there is still limited knowledge regarding their distribution, abundance, metabolism and potential toxicity, as well as the origin of arsenolipids. The lipid-soluble species have been suggested to be biotransformation products formed by primary producers through successive methylation and reduction of inorganic arsenic [21].…”

Section: Acronymsmentioning

confidence: 99%

“…In oils of marine fish [14,[24][25][26], fish meal [17], and in oils of fillet of herring (Clupea harengus) [20] and tuna (Thunnus sp.) [27], AsHCs and AsFAs were identified as major arsenolipids, accounting for 20-70% of the total arsenic present [14,20,25]. Furthermore two species of TMFAsOHs were recently identified as minor arsenolipids in oil of capelin (Mallotus villosus) [15].…”

Section: Acronymsmentioning

confidence: 99%

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A study of lipid- and water-soluble arsenic species in liver of Northeast Arctic cod (Gadus morhua) containing high levels of total arsenic

Sele

Sloth

Julshamn³

et al. 2015

Journal of Trace Elements in Medicine and Biology

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“…In fish muscle, As is usually present mainly as the non-toxic compound arsenobetaine (Francesconi and Kuehnelt, 2002). However, it has been shown for oily fish that arsenolipids can make up a substantial part of the total arsenic concentration, and the toxicity of arsenolipids is largely unknown (Sele et al, 2012;Lischka et al, 2013).…”

Section: Asmentioning

confidence: 99%