A study of lipid- and water-soluble arsenic species in liver of Northeast Arctic cod (Gadus morhua) containing high levels of total arsenic

Sele, Veronika; Sloth, Jens Jørgen; Julshamn, Kale; Skov, Kasper; Amlund, Heidi

doi:10.1016/j.jtemb.2014.12.010

Cited by 21 publications

(14 citation statements)

References 39 publications

(116 reference statements)

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“…Salmon oil contains arsenolipids and since this fish species has high lipid levels in muscle tissue it is likely that arsenolipids would be present in the salmon meals consumed in this study. Cod being a lean fish with most of its lipids in the liver [25], is expected to have low levels of arsenolipids in its muscles, which is consistent with the flatter regression line between increases in plasma As and TSH in the cod group.…”

Section: Discussionsupporting

confidence: 66%

Arsenic in seafood is associated with increased thyroid-stimulating hormone (TSH) in healthy volunteers – A randomized controlled trial

Molin

Ulven

Dahl³

et al. 2017

Journal of Trace Elements in Medicine and Biology

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A B S T R A C TBackground: Exposure to exogenous elements like arsenic (As) may influence thyroid enzymes, thyroidstimulating hormone (TSH), and the two principal thyroid hormones, free thyroxine (FT4) and free triiodothyronine (FT3), but little is known about how this is related to organic arsenicals, the main form in seafood. Aim: To investigate whether a high intake of dietary arsenic from seafood can impact thyroid function and thyroid hormones by examining possible associations with changes in TSH, FT4, FT3 and the FT4:FT3-ratio in plasma. Methods: Thirty-eight healthy subjects were randomized into four groups. During a 14-day semi-controlled dietary study, the subjects ingested daily portions of either 150 g cod, salmon, blue mussels or potato (control). Plasma concentrations of total As, FT3, FT4, TSH and selenium (Se), and urinary concentrations of iodine were monitored. Results: Plasma concentrations of TSH increased significantly in all seafood groups. The change in plasma As, with different coefficients for each seafood group, was the dominant factor in the optimal multiple regression model for change in TSH (R 2 = 0.47). Plasma Se and iodine were negative and positive factors, respectively.There were also indications of changes in FT4, FT3 and the FT4:FT3 ratio consistent with a net inhibiting effect of As on FT4 to FT3 conversion. Conclusion: Ingestion of seafood rich in various organic As species was strongly associated with an increase of the TSH concentrations in plasma. Change in TSH was positively associated with total plasma As, but varied with the type of seafood ingested. These findings indicate that organic dietary As, apparently depending on chemical form, may influence thyroid hormones and function.

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Section: Discussionsupporting

confidence: 66%

Arsenic in seafood is associated with increased thyroid-stimulating hormone (TSH) in healthy volunteers – A randomized controlled trial

Molin

Ulven

Dahl³

et al. 2017

Journal of Trace Elements in Medicine and Biology

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“…Extraction of AsLipids has been achieved successfully using a number of approaches, often with mixtures of polar and non-polar organic solvents (Amayo et al 2011, Amayo et al 2014, Glabonjat et al 2014, Sele et al 2015). The AsLipids can be extracted effectively from fish using MeOH/dichloromethane (DCM)(Amayo et al 2011, Amayo et al 2014) or MeOH/chloroform (Taleshi et al 2010) mixtures, which recover the polar AsLipid species.…”

Section: Analytical/monitoring Considerationsmentioning

confidence: 99%

Human exposure to organic arsenic species from seafood

Taylor

Goodale

Raab

et al. 2017

Science of The Total Environment

380

256

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Seafood, including finfish, shellfish, and seaweed, is the largest contributor to arsenic (As) exposure in many human populations. In contrast to the predominance of inorganic As in water and many terrestrial foods, As in marine-derived foods is present primarily in the form of organic compounds. To date, human exposure and toxicological assessments have focused on inorganic As, while organic As has generally been considered to be non-toxic. However, the high concentrations of organic As in seafood, as well as the often complex As speciation, can lead to complications in assessing As exposure from diet. In this report, we evaluate the presence and distribution of organic As species in seafood, and combined with consumption data, address the current capabilities and needs for determining human exposure to these compounds. The analytical approaches and shortcomings for assessing these compounds are reviewed, with a focus on the best practices for characterization and quantitation. Metabolic pathways and toxicology of two important classes of organic arsenicals, arsenolipids and arsenosugars, are examined, as well as individual variability in absorption of these compounds. Although determining health outcomes or assessing a need for regulatory policies for organic As exposure is premature, the extensive consumption of seafood globally, along with the preliminary toxicological profiles of these compounds and their confounding effect on assessing exposure to inorganic As, suggests further investigations and process-level studies on organic As are needed to fill the current gaps in knowledge.

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“…Besides the water-soluble arsenic species, marine organisms can also contain appreciable quantities of lipid-soluble arsenic oen constituting 10-30% of the total arsenic content, 1 or even higher in fatty sh such as sashimi tuna, 2 or in lipid-rich organs of marine sh. 3 Although lipid-soluble arsenic in cod-liver was rst reported in 1928, 4 the identity of the arsenic compounds remained unknown until the rst structural elucidation of an arsenosugar phospholipid in 1988 by Morita and Shibata. 5 Since then more than 100 arsenolipids have been identied, all of them in the last 11 years following improvements in analytical techniques for their detection and identication.…”

Section: Introductionmentioning

confidence: 99%

Lipid-soluble arsenic species identified in the brain of the marine fish skipjack tuna (Katsuwonus pelamis) using a sequential extraction and HPLC/mass spectrometry

Stiboller

Freitas

Francesconi

et al. 2019

J. Anal. At. Spectrom.

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A study of lipid- and water-soluble arsenic species in liver of Northeast Arctic cod (Gadus morhua) containing high levels of total arsenic

Cited by 21 publications

References 39 publications

Arsenic in seafood is associated with increased thyroid-stimulating hormone (TSH) in healthy volunteers – A randomized controlled trial

Arsenic in seafood is associated with increased thyroid-stimulating hormone (TSH) in healthy volunteers – A randomized controlled trial

Human exposure to organic arsenic species from seafood

Lipid-soluble arsenic species identified in the brain of the marine fish skipjack tuna (Katsuwonus pelamis) using a sequential extraction and HPLC/mass spectrometry

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