The Heyde syndrome: Proposal for a unifying concept explaining the association of aortic valve stenosis, gastrointestinal angiodysplasia and bleeding

Sucker, Christoph

doi:10.1016/j.ijcard.2006.01.014

Cited by 35 publications

(32 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Age-dependent tissue degeneration was a risk factor for the development of both, aortic valve stenosis and angiodysplasia [7,12,[48][49][50]. It could explain the fact that the incidence of both aortic stenosis and lower GI bleeding increases with age [51].…”

Section: Age-related Degenerative Processmentioning

confidence: 99%

“…Congenital connective tissue defects may exaggerate age-dependent tissue degeneration [1,7,9,12,29,31,39,53,54]. A combination of high tension and weak supporting connective tissue (deficiency of collagen type IV) would be worse in the colon [29,31].…”

Section: Genetic Predispositionmentioning

confidence: 99%

“…An unexplained feature of Heyde syndrome is the presence of shear stress induced haematological abnormalities in up to 90% of patients with AS while only a small minority bleed and that also only from the GI tract [7]. Sucker emphasised the multifactorial pathogenesis of this syndrome where only patients with multiple predisposing factors (both generalised and local) will bleed [7].…”

Section: Multifactorial Pathogenesismentioning

confidence: 99%

“…Sucker emphasised the multifactorial pathogenesis of this syndrome where only patients with multiple predisposing factors (both generalised and local) will bleed [7]. This concept could explain several conflicting features of this syndrome.…”

Section: Multifactorial Pathogenesismentioning

confidence: 99%

“…Chronic gastrointestinal bleeding associated with calcific aortic stenosis is a recognised association [2,3]. Despite several studies on this entity there are still many unanswered questions [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Intestinal angiodysplasia and aortic valve stenosis: let's not close the book on this association

Mishra¹,

Kováč²,

Caestecker³

et al. 2009

European Journal of Cardio-Thoracic Surgery

View full text Add to dashboard Cite

SummaryThe association between gastrointestinal (GI) bleeding due to angiodysplasia of the large intestine and calcific aortic stenosis (AS) has been a matter of debate. Recent studies suggest that this association is related to subtle alterations in plasma coagulation factors. von Willebrand factor is the strongest possible link between aortic stenosis and bleeding associated with GI angiodysplasia. Physicians should be aware of this entity when dealing with elderly patients presenting either with GI bleeding or with AS. A high index of suspicion and appropriate diagnostic procedures followed by prompt treatment could be life saving. Several questions related to the pathogenesis and optimal management remain unanswered. Aortic valve replacement appears to offer the best hope of long-term resolution of the bleeding, and should be considered in most cases. The association between chronic gastrointestinal bleeding in elderly patients and aortic stenosis becomes more relevant with the advent of transcatheter aortic valve implantation which can be offered even to elderly patients with comorbidities which could make conventional surgery impossible. #

show abstract