The Heterogenicity of Parotid Gland Squamous Cell Carcinoma: A Study of 49 Patients

Franzen, Achim; Lieder, Anja; Guenzel, Thomas; Buchali, A.

doi:10.21873/invivo.11696

Cited by 18 publications

(28 citation statements)

References 19 publications

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“…While all metastatic SCCs involved the parotid gland, primary SCCs affected both parotid and submandibular glands. The parotid gland is the most commonly involved major gland in primary SCC [1,3,14], although many isolated cases of submandibular gland origin have been reported [4,5,16,22,23]. The location of primary SCC as well as the age and sex of the patients were similar to those reported for salivary duct carcinomas.…”

Section: Discussionsupporting

confidence: 62%

“…SCC of the salivary gland is an uncommon occurrence, and most cases represent metastases from other head and neck sites [ 1 , 3 , 14 ]. There are few studies on primary SCC of the salivary gland [ 3 , 6 , 14 ], and a histologic comparison of primary and metastatic SCC has not been reported. The purpose of this study was to share helpful histologic features and diagnostic challenges between primary SCC and metastatic SCC of the salivary gland.…”

Section: Discussionmentioning

confidence: 99%

“…The purpose of this study was to share helpful histologic features and diagnostic challenges between primary SCC and metastatic SCC of the salivary gland. Though previous studies researched variable kinds of salivary gland tumors including primary and metastatic tumors, the present series studied only SCCs of the salivary gland [ 6 , 14 - 16 ]. Therefore, primary SCCs of this study comprised a higher proportion (8 of 16 cases, 50%) among the total SCCs of the salivary gland retrieved over a 19-year period at one institution ( Tables 1 , 2 ).…”

Section: Discussionmentioning

confidence: 99%

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Primary squamous cell carcinoma of the salivary gland: immunohistochemical analysis and comparison with metastatic squamous cell carcinoma

Song

Choi

et al. 2020

J Pathol Transl Med

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Background Primary squamous cell carcinoma (SCC) of the salivary gland is a rare disease, and distinguishing primary SCC from metastatic SCC is difficult. This study investigated the histological and immunohistochemical differences between primary and metastatic salivary gland SCC to improve the accuracy of diagnosis and to explore the pathogenesis of this disease. Methods Data of 16 patients who underwent surgery for SCC of salivary glands between 2000 and 2018 at Asan Medical Center were retrieved. Eight patients had a history of SCC at other sites, and eight patients had only salivary gland SCC. Immunostaining for p16, p53, androgen receptor (AR), gross cystic disease fluid protein 15 (GCDFP-15), and c-erbB2, as well as mucicarmine staining, were compared between the two groups. Results Most tumors were located in the center of the salivary glands with extraparenchymal extension. The histology of primary SCC of the salivary gland was consistent with moderately differentiated SCC with extensive desmoplastic reaction and peritumoral inflammation. Involvement of the salivary gland ducts and transition into the ductal epithelium were observed in two cases. Metastatic SCC resembled the primary tumor histologically and was associated with central necrosis. Both groups exhibited negative mucin staining. Two, one, and one primary SCC case exhibited AR, GCDFP-15, and c-erbB2 positivity, respectively. Conclusions A subset of primary SCCs originated in salivary ducts or was related to salivary duct carcinoma. Distinguishing primary from metastatic SCC of the salivary gland is difficult using histologic features and immunoprofiles. A comprehensive review of the medical history is essential.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary squamous cell carcinoma of the salivary gland: immunohistochemical analysis and comparison with metastatic squamous cell carcinoma

Song

Choi

et al. 2020

J Pathol Transl Med

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“…The current case qualifies as SCC but showed unusual histological and clinical features leading to consideration of an alternative diagnosis: (1) the tumor presented at unusually young age (24 years in contrast to a mean age of 79 years for SCC of the parotid reported in the literature [4]; (2) it shows adnexal-type keratinization and variable other features reminiscent of adnexal-type differentiation; and (3) no other Clear cell aggregates mimicking mucoepidermoid carcinoma are evident focally. d CK19 immunostaining highlights abortive and wellformed rare ductal spaces primary tumor could be found by thorough clinical investigation.…”

Section: Discussionmentioning

confidence: 87%

YAP1-MAML2-Rearranged Poroid Squamous Cell Carcinoma (Squamoid Porocarcinoma) Presenting as a Primary Parotid Gland Tumor

Agaimy

Stoehr

Tögel

et al. 2020

Head and Neck Pathol

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Porocarcinoma (synonym: malignant eccrine poroma) is a rare aggressive carcinoma type with terminal sweat gland duct differentiation. The squamous variant of porocarcinoma is even less frequent and might be indistinguishable from conventional squamous cell carcinoma (SCC). We herein describe the first case of a carcinoma presenting as a primary parotid gland malignancy in a 24-year-old male without any other primary tumor. Total parotidectomy and neck dissection were performed followed by adjuvant chemoradiation. The patient remained alive and well 10 months after diagnosis. Histology showed keratinizing SCC infiltrating extensively the parotid gland with subtle poroid cell features. Oncogenic HPV infection was excluded by DNA-based testing. NGS analysis using the TruSight RNA fusion panel (Illumina) revealed a novel YAP1-MAML2 gene fusion. This gene fusion was reported recently in a subset of cutaneous porocarcinoma and poroma. This case of poroid SCC (or squamoid porocarcinoma) adds to the differential diagnosis of SCC presenting as parotid gland tumor and highlights the value of molecular testing in cases with unusual presentation.

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“…It is reported that primary squamous cell carcinoma of parotid gland has no different characteristics relative to squamous cell carcinoma of other atomistic sites 10 . Still, evidence-based survival estimates of super cial and total parotidectomy for the symptomatic super cial parotid malignancy are lacking.…”

Section: Discussionmentioning

confidence: 99%

Facial Nerve Preservation In Treatment Of Primary Parotid Squamous Cell Carcinoma: A Case Report

Huang¹,

Cheng²,

Luo³

et al. 2021

Preprint

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BackgroundPrimary squamous cell carcinoma rarely occurs in parotid gland. Partial, superficial or total parotidectomy as well as radical resection is performed based on patients’ conditions. For patients with symptoms of facial nerve weakness or dysfunction, facial nerve preservation is considered justifiably, whereas groundlessly if the malignancy is asymptomatic. We hereby reported a case of symptomatic primary parotid squamous cell carcinoma performed with total parotidectomy and facial nerve preservation.Case summaryWith the complaint of an asymptomatic mass in right parotid gland for five years and it grew aggressively and pricked recent months, a 46-year-old man visited the local hospital two week ago. A biopsy was performed and squamous cell carcinoma in right parotid gland was diagnosed. He was subsequently referred to Tongji hospital in Wuhan, China. Physical exam revealed a scar in the right parotid gland and impaired function of right facial nerves. An immoveable mass was touched in lower and posterior pole of right parotid gland. The mass was about 2.1*3.1 cm without clear boundary, and moderate pain was observed. No obvious enlarged lymph node was touched in right submandibular region and neck. Magnetic resonance imaging revealed a 1.6*2.4 cm nodular located in a diffuse suspicious mass in right parotid gland. Radical resection of the malignancy was rejected due to the inevitable facioplegia. Considering the short history of tumor aggressive behaviors, unique anatomical structure of parotid gland and absent sign of lymph node metastasis, total parotidectomy with facial nerve preservation and elective right neck dissection were performed. Finial pathological examination confirmed squamous cell carcinoma of right parotid gland. Post-operation radiotherapy was scheduled in the following month. Restoration of facial nerve function was observed in two months later, absent local recurrence and distant metastasis was observed in the three years’ follow-up.Conclusion Primary parotid squamous cell carcinoma is rarely observed in clinical and facial nerve sacrifice requires great attention in treatment. Based on carefully evaluation of patients’ conditions before treatment, individualized treatment is crucial for improvement of patients’ quality of life while completely dissection of the malignancy.

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The Heterogenicity of Parotid Gland Squamous Cell Carcinoma: A Study of 49 Patients

Cited by 18 publications

References 19 publications

Primary squamous cell carcinoma of the salivary gland: immunohistochemical analysis and comparison with metastatic squamous cell carcinoma

Primary squamous cell carcinoma of the salivary gland: immunohistochemical analysis and comparison with metastatic squamous cell carcinoma

YAP1-MAML2-Rearranged Poroid Squamous Cell Carcinoma (Squamoid Porocarcinoma) Presenting as a Primary Parotid Gland Tumor

Facial Nerve Preservation In Treatment Of Primary Parotid Squamous Cell Carcinoma: A Case Report

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