The heritability of strabismus

Paul, T.; Hardage, Lani

doi:10.3109/13816819409056905

Cited by 61 publications

(45 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A higher prevalence of strabismus among families of an affected individual have been demonstrated in several population studies (Ziakas et al 2002). A cohort study of 7100 strabismic patients revealed that about 30 % of the patients had a close relative with strabismus (Paul and Hardage 1994). Cotter et al reported association between positive family history of strabismus and XT, which was independent from hereditability of the refractive error (Cotter et al 2011).…”

Section: Discussionmentioning

confidence: 95%

“…Previous twin studies showed a concordance rate of 73 to 82 % among monozygotic twins and 35 to 47 % among dizygotic twins (Paul and Hardage 1994;Matsuo et al 2002). A higher prevalence of strabismus among families of an affected individual have been demonstrated in several population studies (Ziakas et al 2002).…”

Section: Discussionmentioning

confidence: 99%

“…The genetics of common forms of comitant strabismus is not well identified (Khan et al 2011a). The mode of comitant strabismus inheritance may be dominant, recessive, or multifactorial (Ziakas et al 2002;Paul and Hardage 1994). Several chromosomal susceptibility loci have been suggested (Fujiwara et al 2003).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A study of consanguineous marriage as a risk factor for developing comitant strabismus

2015

View full text Add to dashboard Cite

Inheritance has an important role in the etiology of comitant strabismus. Consanguineous marriage is a leading factor in birth defects in which inheritance has a role. The aim of this study is to reveal if consanguineous marriage increases the risk of developing comitant strabismus. We included 461 patients who underwent primary surgery for comitant strabismus in Shiraz University Khalili Hospital (Fars province, southern Iran) between years 2003 and 2013 in our study. All the patients were living in Shiraz, Iran. Patients were categorized into the following 4 groups: (1) intermittent or constant exotropia, (2) infantile esotropia, (3) nonaccommodative acquired esotropia, and (4) accommodative acquired esotropia. A total of 421 healthy children who were born in Shiraz, at the same period of time, were also studied as a control group. Presence and type of the consanguineous marriages were evaluated in the parents of the patients and control group by a questionnaire. Mean of inbreeding coefficient (α) was calculated in each group of patients and was compared with those of control group. The proportion of parental first cousin marriage was 37.7 and 23.5 % among patient and control groups. The mean of inbreeding coefficients (α) were 0.0236, 0.0283, 0.0288, and 0.0236 in four groups of the patients, respectively. The mean of inbreeding coefficient was 0.0263 in total patients, which was significantly higher than 0.0164 of control group (T=5.27, df=880, P<0.001).Patients with non-accommodative acquired esotropia had the highest mean of inbreeding coefficient (α) (0.0288). It seems that recessive form of inheritance plays an important role in the etiology of comitant strabismus. Modified screening programs may be needed for earlier detection of strabismus in the offspring of consanguineous couples.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A study of consanguineous marriage as a risk factor for developing comitant strabismus

2015

View full text Add to dashboard Cite

show abstract

“…Later studies have pointed out that at least two types, i.e., congenital esotropia (Francois 1985) and microtropia both show multifactorial inheritance (Maumenee et al 1986;Cantolino & v Noorden 1969) and are caused by multiple and independently inherited sensory and motor anomalies. The mode of inheritance of other forms of strabismus that clusters in families is still somewhat obscure (Paul & Hardage 1994).…”

mentioning

confidence: 99%

“…Studies in Denmark and Finland indicate that the prevalence is greatest at 7 years of age and that the prevalence then is a little less than 5% of the population (Frandsen 1960;Kö hler & Stigmar 1978;Laatikainen & Erkkilä 1980). This should be compared with the prevalence among those with a family history of squint, ranging from 13% to 65% in different studies (Paul & Hardage 1994).…”

mentioning

confidence: 99%

Inheritance of strabismus and the gain of using heredity to determine populations at risk of developing strabismus

Abrahamsson¹,

Magnusson²,

Sjöstrand³

1999

Acta Ophthalmologica Scandinavica

View full text Add to dashboard Cite

ABSTRACT.Purpose: In the Nordic countries 2 to 4% of the population squint or have been squinting. Since strabismus is one of the major causes of amblyopia early detection and treatment is important for preventing this development. For centuries it has been recognized that strabismus is hereditary. Identifying individuals with a family history of squinting could give access to a risk population for a selective screening. Methods and results: 1571 children were selected for this study. All children that took part in a voluntary eye examination at one year of age (born 1978-1983) in the city of Västerås, Sweden and that had a family history of strabismus were selected together with controls. The study was a 6-year follow-up from 1 to 7 years of age. Parental knowledge of squint among relatives and measured high hyperopia (±3.0 D) present at 1 year of age were each and in combination evaluated as a risk indicator for development of strabismus between 1 to 7 years of age. Conclusion:The study indicates that a family history of squint in combination with measured high hyperopia can be used in a selective screening to identify a population with an increased risk of 4 to 6 times for developing strabismus. Among the children with parental knowledge of squint among several relatives of both the parents, those with high hyperopia developed strabismus in almost every second case while this was the case in only approximately 10% of those with low hyperopia. Finally, heredity is an important risk indicator that can be used for selective screening purpose. Its potential as a risk indicator is substantially increased when combined with a high hyperopia.

show abstract

Genetic Basis of Congenital Strabismus

Engle¹

2007

Arch Ophthalmol

View full text Add to dashboard Cite

S trabismus is misalignment of one eye in relation to the other, resulting in failure of the 2 eyes to simultaneously focus on the same image and loss of binocular vision. Strabismus affects 2% to 4% of the population and can result in amblyopia, which is often not discovered in time to initiate effective treatment. Thus, an understanding of the genetic underpinnings of strabismus may help identify patients at risk early enough to prevent disability and may lead to new preventive or therapeutic approaches.

show abstract

The heritability of strabismus

Cited by 61 publications

References 76 publications

A study of consanguineous marriage as a risk factor for developing comitant strabismus

A study of consanguineous marriage as a risk factor for developing comitant strabismus

Inheritance of strabismus and the gain of using heredity to determine populations at risk of developing strabismus

Genetic Basis of Congenital Strabismus

Contact Info

Product

Resources

About