A study of consanguineous marriage as a risk factor for developing comitant strabismus

Abstract

Inheritance has an important role in the etiology of comitant strabismus. Consanguineous marriage is a leading factor in birth defects in which inheritance has a role. The aim of this study is to reveal if consanguineous marriage increases the risk of developing comitant strabismus. We included 461 patients who underwent primary surgery for comitant strabismus in Shiraz University Khalili Hospital (Fars province, southern Iran) between years 2003 and 2013 in our study. All the patients were living in Shiraz, Iran. Patients were categorized into the following 4 groups: (1) intermittent or constant exotropia, (2) infantile esotropia, (3) nonaccommodative acquired esotropia, and (4) accommodative acquired esotropia. A total of 421 healthy children who were born in Shiraz, at the same period of time, were also studied as a control group. Presence and type of the consanguineous marriages were evaluated in the parents of the patients and control group by a questionnaire. Mean of inbreeding coefficient (α) was calculated in each group of patients and was compared with those of control group. The proportion of parental first cousin marriage was 37.7 and 23.5 % among patient and control groups. The mean of inbreeding coefficients (α) were 0.0236, 0.0283, 0.0288, and 0.0236 in four groups of the patients, respectively. The mean of inbreeding coefficient was 0.0263 in total patients, which was significantly higher than 0.0164 of control group (T=5.27, df=880, P<0.001).Patients with non-accommodative acquired esotropia had the highest mean of inbreeding coefficient (α) (0.0288). It seems that recessive form of inheritance plays an important role in the etiology of comitant strabismus. Modified screening programs may be needed for earlier detection of strabismus in the offspring of consanguineous couples.

A hospital based survey on the pattern of eye diseases in Arar, Saudi Arabia

“…The high incidence of strabismus in our study is in line with the other studies related to vision screening among school children in Saudi Arabia [35,36]. These higher rates of strabismus among Saudi children may be due to higher prevalence of consanguinity due to more common marriage among relatives of the same families [37][38][39].…”

Profile of Strabismus at a Tertiary Care Hospital in Kashmir

“…Ziakas et al (26.1%) and Bagheri et al (37.7%) had similar observations. 13,14 Prematurity, low birth weight, low Apgar scores, and a family history of strabismus are considered significant risk factors for strabismus. 15,16 Our study cohort had only 4% preterm born patients and 18% had history of neonatal ICU admission.…”

The Effect of Consanguineous Marriage on Mental Health among the Students of the Shahrekord University of Medical Sciences

“…The results of these studies revealed a relation between consanguineous marriages and mental retardation, mortality in fetus and infants and strabismus [11][12][13]. The association between parental consanguinity and mental health is an important issue, research in this field has not been done in Iran.…”