The Heritability of Dupuytren’s Disease: Familial Aggregation and Its Clinical Significance

Hindocha, Sandip; John, Sally; Stanley, John; Watson, Stewart; Bayat, Ardeshir

doi:10.1016/j.jhsa.2005.09.018

Cited by 99 publications

(69 citation statements)

References 22 publications

(22 reference statements)

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“…The sample in this study is also comparable to other previously performed studies concerning age (2), heredity (29), and diabetes (4,30). Further, the drop-outs did not differ from the participants with respect to age, sex, duration of symptoms, heredity, diabetes, or unilateral or bilateral disease.…”

Section: Discussionsupporting

confidence: 86%

Evaluation of Activity Limitation and Digital Extension in Dupuytren's Contracture Three Months after Fasciectomy and Hand Therapy Interventions

Engstrand¹,

Borén²,

Liedberg³

2009

Journal of Hand Therapy

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Section: Discussionsupporting

confidence: 86%

Evaluation of Activity Limitation and Digital Extension in Dupuytren's Contracture Three Months after Fasciectomy and Hand Therapy Interventions

Engstrand¹,

Borén²,

Liedberg³

2009

Journal of Hand Therapy

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“…Females are older at the time of their first operation and have a higher recurrence rate and heritability [44] compared to males [104].…”

Section: Epidemiology Linked To Etiology Of Ddmentioning

confidence: 99%

Epidemiological Evaluation of Dupuytren's Disease Incidence and Prevalence Rates in Relation to Etiology

Hindocha

McGrouther

Bayat

2009

Hand (New York, N,Y.)

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169

137

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Dupuytren's Disease (DD) is a common, fibroproliferative disorder affecting the palmar surface of the hands which is often irreversible and progressive. Understanding the epidemiology of DD is important in order to provide clues to its etiopathogenesis. This review aims to evaluate the epidemiological studies carried out in DD since 1951. Studies evaluating the epidemiology of DD were searched using Medline, Pubmed, and Scopus which dated back from 1951 to current date. Inclusion criteria were any studies investigating the prevalence or incidence of DD in any population group. A total of 620 articles were cited. Forty-nine studies were subsequently identified as relevant to evaluating the epidemiology of DD. The prevalence of DD in all studies increased with age with a male to female ratio of approximately 5.9:1. Prevalence rates ranged from 0.2% to 56% in varying age, population groups, and methods of data collection. The highest prevalence rate was reported in a study group of epileptic patients. Although, only one study calculated the incidence (as opposed to prevalence) of DD to be equal to 34.3 per 100,000 men (0.03%). In conclusion, the prevalence of DD in different geographical locations is extremely variable, and it is not clear whether this is genetic, environmental, or a combination of both. The majority of the prevalence studies have been conducted in Scandinavia or the UK, and the vast changes in population structure, the changes in prevalence of associated diseases, and the change in diagnostic criteria of DD makes understanding the epidemiology of this condition difficult.

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“…11 DD is thought to be the most common hereditary connective tissue disorder in Caucasians. 12 The prevalence of DD in different geographical locations is extremely variable (0.2-56%), and its not clear whether this is genetic, environmental or a combination of both. Population structure, the prevalence of associated diseases and the diagnostic criteria of DD, makes the understanding of epidemiology quite difficult.…”

Section: Introductionmentioning

confidence: 99%

The association between Peyronie's and Dupuytren's disease

et al. 2011

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Peyronie's disease (PD) is known to be associated with Dupuytren's disease (DD) since 1828. The aim of this study was to investigate the coexistence of DD in a consecutive series of patients with PD and their clinical characteristics. From January 1988 to December 2009 all patients, presenting at our outpatient urological clinic, with PD were also examined for DD. The sample consisted of 415 male subjects with PD, 89 (22.1%) also had DD. A total of 28 men (6.7%) reported to have one or more first or second degree relatives with DD.

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The Heritability of Dupuytren’s Disease: Familial Aggregation and Its Clinical Significance

Cited by 99 publications

References 22 publications

Evaluation of Activity Limitation and Digital Extension in Dupuytren's Contracture Three Months after Fasciectomy and Hand Therapy Interventions

Evaluation of Activity Limitation and Digital Extension in Dupuytren's Contracture Three Months after Fasciectomy and Hand Therapy Interventions

Epidemiological Evaluation of Dupuytren's Disease Incidence and Prevalence Rates in Relation to Etiology

The association between Peyronie's and Dupuytren's disease

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