The hereditary stomatocytoses

Flatt, Joanna F.; Bruce, Lesley J.

doi:10.3324/haematol.2009.010041

Cited by 18 publications

(13 citation statements)

References 18 publications

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“…In that particular case, while echinocytes were considered as morphological signs of oxidative stress, the stomatocytes were described as "anti-oxidative" stress signs. It should be noticed here that "classic" stomatocytosis is associated with redox imbalance and cytoskeleton modifications [28], while the hereditary stomatocytoses are often connected to membrane deficiency and modifications in stomatin and Band 3 proteins [29]. In our samples, the contribution of the secondary stomatin depletion (see Section 3.5) and probably of other corpuscular alterations in the stomatocytic transformation cannot be excluded.…”

Section: Morphological Analysis Of Pre-hd Rbcs-ros Correlationsmentioning

confidence: 89%

Oxidative stress-associated shape transformation and membrane proteome remodeling in erythrocytes of end stage renal disease patients on hemodialysis

Antonelou

Kriebardis

Velentzas

et al. 2011

Journal of Proteomics

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Section: Morphological Analysis Of Pre-hd Rbcs-ros Correlationsmentioning

confidence: 89%

Oxidative stress-associated shape transformation and membrane proteome remodeling in erythrocytes of end stage renal disease patients on hemodialysis

Antonelou

Kriebardis

Velentzas

et al. 2011

Journal of Proteomics

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“…An imbalance of intracellular cation content can result in alteration of red cell volume (e.g. dehydration or swelling), which is the underlying cause of hereditary stomatocytosis, in which the leak rate of cation exceeds the pump rate .…”

Section: Introductionmentioning

confidence: 99%

ICSH guidelines for the laboratory diagnosis of nonimmune hereditary red cell membrane disorders

King

Garçon²,

Hoyer

et al. 2015

Int J Lab Hematology

138

141

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Specialist tests provide additional evidence in supporting the diagnosis and that will facilitate the management of the patient. In the case of a patient's clinical phenotype being more severe than the affected members within the immediate family, molecular testing of all family members is useful for confirming the diagnosis and allows an insight into the molecular basis of the abnormality such as a recessive mode of inheritance or a de novo mutation.

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“…Note that microparticles with all of the shapes shown in Figure 3 were actually encountered in our SEM images. The work of Deuling and Helfrich does not describe stomatocyte blood cells; the mouth‐shape geometry is believed not to stem from curvature‐elastic forces, but rather from fact that the cell membrane is partially ruptured 39 …”

Section: Discussionmentioning

confidence: 99%

“…Theoretical contours of four different erythrocyte cup‐cell shapes, according to Reference 39. (a) Contour of the cup cell for which the ratio V (enclosed volume) / V 0 (volume of a sphere with the same outer surface) equals 0.853.…”

Section: Discussionmentioning

confidence: 99%

Polymer microparticles with a cavity designed for transarterial chemo‐embolization with crystalline drug formulations

et al. 2020

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Transarterial chemo‐embolization with drug‐eluting embolic beads (DEB‐TACE) is still evolving. Recent developments include the introduction of radiopaque (X‐ray imageable) drug‐eluting particles. Here, we report on conceptually different radiopaque polymeric drug‐eluting embolic particles, which are (i), cross‐linked poly(methacrylates); (ii), radiopaque; (iii), microporous. Furthermore, the particles are not perfectly spherical: they have a large indentation in the sense that they are either a spherical/cup‐shaped or ellipsoid/mouth‐shaped. The micropores and the large indentation can confer useful features upon the particles, since they can be filled with a crystalline lipophilic chemotherapeutic drug. It is important, in this respect that (i), many potent chemotherapeutics are lipophilic and crystalline; (ii), available drug‐eluting beads (DEBs) have the limitation that they can only be used in combination with water‐soluble chemotherapeutic agents. Cup‐ and mouth‐shaped particles were obtained in a Cu(0) catalyzed free‐radical polymerization reaction. The microparticles could be charged with crystalline drug, in such a manner that the crystals reside in both the micropores and the large cavity, and in quantities that would be required for effective local chemotherapy. The antifungal drug voriconazole, lipophilic, and crystalline, was used to demonstrate this. We believe that the ability of the microporous/cavitated DEBs to carry lipophilic chemotherapeutic drugs is especially important. DEB‐TACE is likely to become a cornerstone method of interventional oncology in the years ahead, and the new embolic particles described herein hold the promise of becoming scope widening for the technique.

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The hereditary stomatocytoses

Abstract: © F e r r a t a S t o r t i F o u n d a t i o n

Cited by 18 publications

References 18 publications

Oxidative stress-associated shape transformation and membrane proteome remodeling in erythrocytes of end stage renal disease patients on hemodialysis

Oxidative stress-associated shape transformation and membrane proteome remodeling in erythrocytes of end stage renal disease patients on hemodialysis

ICSH guidelines for the laboratory diagnosis of nonimmune hereditary red cell membrane disorders

Polymer microparticles with a cavity designed for transarterial chemo‐embolization with crystalline drug formulations

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