The hepatitis B virus polymerase

Clark, Daniel N.; Tajwar, Razia; Hu, Jianming; Tavis, John E.

doi:10.1016/bs.enz.2021.06.010

Cited by 6 publications

(3 citation statements)

References 164 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to other Orthohepadnaviruses, the DCH genome encodes four overlapping open reading frames for polymerase (P), surface (S), core (C), and X proteins (Aghazadeh et al, 2018;Magnius et al, 2020). In HBV, P proteins are multifunctional enzymes with a protein-priming function, both RNA-and DNA-dependent DNA synthesis function, and ribonuclease H activity (Clark et al, 2021). S proteins (or HBsAg) play an important role in viral attachment and host immune response manipulation (Churin et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Global Prevalence of Domestic Cat Hepadnavirus: An Emerging Threat to Cats’ Health?

et al. 2022

View full text Add to dashboard Cite

Hepatitis B is an infectious hepatocellular disease of global concern caused by hepatitis B virus (HBV), which belongs to Hepadnaviridae. Recently, a novel HBV-like virus, domestic cat hepadnavirus (DCH), was detected from an immunocompromised cat with a hepatic disease in Australia. Subsequent molecular investigation by independent research groups revealed that its prevalence rates were 6.5% in Australia, 10.8% in Italy, 12.4% in Thailand, 12.3% in Malaysia, 3.08% in the United Kingdom, and 0.78% in Japan. Although the correlation between DCH infection and hepatic diseases remains to be elucidated, understanding the diversity of circulating DCH will contribute to its prevention and control in domestic cats. Herein, we summarize the current epidemiological data of DCH in these countries.

show abstract

Section: Introductionmentioning

confidence: 99%

Global Prevalence of Domestic Cat Hepadnavirus: An Emerging Threat to Cats’ Health?

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In these retroviruses, the RNase H domain exists in the reverse transcriptase proteins and is necessary for viral replication [20, 21]. In Hepatitis B virus (HBV), the RNase H domain is one of the four functional domains of HBV polymerase [22]. It is an indispensable enzyme for synthesizing negative-strand DNA of the HBV genome, which participates in the packaging of HBV DNA [20, 23].…”

Section: Discussionmentioning

confidence: 99%

Circular DNA vcDNA-S7 derived from segmented-dsRNA virus BmCPV attenuated viral infection through RNase H1

Pan,

Tong,

Ding

et al. 2024

Preprint

View full text Add to dashboard Cite

Viral circDNA derived from insect positive-sense single-stranded RNA viruses plays a crucial role in regulating viral infections depending on the RNAi pathway. Our previous research has revealed that Bombyx mori cypovirus (BmCPV), a segmented-dsRNA virus, can generate viral circDNA vcDNA-S7, which can be transcribed to form RNA and further processed into small RNAs to defend against the virus through RNAi. However, whether vcDNA-S7 employs other mechanisms to resist the viruses. Presently, vcDNA-S7 has been found to resist BmCPV infection via a novel mechanism that depends on ribonuclease RNase H1 activity. It was found that the expression level of RNase H1 increased upon BmCPV infection (RNA virus) but not upon B. mori nucleopolyhedrovirus (BmNPV) (DNA virus) infection. RNase H1 has been shown to negatively regulate BmCPV infections. In addition, vcDNA-S7 was found to form a heteroduplex with the viral RNA and subsequently recruit RNase H1 to degrade the viral RNA within the heteroduplex, ultimately leading to the suppression of viral replication. Furthermore, the resistance of vcDNA-S7 to viruses was significantly reduced when cellular RNase H1 gene was silenced. These findings not only reveal a new antiviral mechanism involving circular DNA formed by reovirus but also offer intriguing insights into the antiviral function of RNase H1 in cells.

show abstract

“…Either not expressed or relevance unclear fetal/infantile disease DNA polymerase HBV polymerase (P) protein is a four-domain multifunctional enzyme that has protein-priming, RNA-and DNAdependent DNA synthesis (i.e., RT), and ribonuclease H activities. 41…”

Section: Genome-associated Polyproteinmentioning

confidence: 99%

Hepatitis B Infections in Neonates

Anand¹,

Singh²,

Schelonka³

et al. 2022

Newborn

View full text Add to dashboard Cite

Hepatitis B infections are estimated to affect more than 2 billion people worldwide. The overall prevalence of HBsAg positivity in plasma is reported to be 3.5%, but it varies depending on the geographic area. Mother-to-child infection is the predominant mode of transmission in high-prevalence areas. In exposed infants, universal hepatitis B vaccination and the administration of hepatitis B immunoglobulin (HBIg) within 12 hours following the birth can reduce the risk of perinatal infection. The rates of progression to chronic hepatitis B infection depend on the age of infection and are the highest in perinatally acquired infections, thus underscoring the importance of measures to reduce transmission. Timely identification and treatment of the affected pregnant women and immunoprophylaxis of newborn infants are of paramount importance to reduce the burden of chronic infection.

show abstract

The hepatitis B virus polymerase

Cited by 6 publications

References 164 publications

Global Prevalence of Domestic Cat Hepadnavirus: An Emerging Threat to Cats’ Health?

Global Prevalence of Domestic Cat Hepadnavirus: An Emerging Threat to Cats’ Health?

Circular DNA vcDNA-S7 derived from segmented-dsRNA virus BmCPV attenuated viral infection through RNase H1

Hepatitis B Infections in Neonates

Contact Info

Product

Resources

About