The hemodynamic patterns in hypertensive men and women of different age

Krzesiński, Paweł; Stańczyk, Adam; Gielerak, Grzegorz; Piotrowicz, Katarzyna

doi:10.1038/jhh.2015.63

Cited by 7 publications

(6 citation statements)

References 36 publications

(41 reference statements)

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“…A previous study by Scuteri et al [ 46 ] found that increased aortic stiffness (a sign of reduced arterial compliance) is implicated in the age-associated rise in SBP and PP; such a finding was noticed in our patients with D-SDH and ISH subtypes (Table 1 ). Similar findings were also reported by Krzesinski et al employing impedance cardiography [ 31 ]. Instead, younger individuals showed a preserved C t and characteristically presented with IDH or ND-SDH subtypes (Table 1 ).…”

Section: Discussionsupporting

confidence: 91%

Hemodynamic profiles of arterial hypertension with ambulatory blood pressure monitoring

et al. 2023

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Blood pressure (BP) measurements obtained during a twenty-four-hour ambulatory blood pressure monitoring (24 h ABPM) have not been reliably applied to extract arterial hemodynamics. We aimed to describe the hemodynamic profiles of different hypertension (HT) subtypes derived from a new method for total arterial compliance (Ct) estimation in a large group of individuals undergoing 24 h ABPM. A cross-sectional study was conducted, which included patients with suspected HT. Cardiac output, Ct, and total peripheral resistance (TPR) were derived through a two-element Windkessel model without having a pressure waveform. Arterial hemodynamics were analyzed according to HT subtypes in 7434 individuals (5523 untreated HT and 1950 normotensive controls [N]). The individuals mean age was 46.2 ± 13.0 years; 54.8% were male, and 22.1% were obese. In isolated diastolic hypertension (IDH), the cardiac index (CI) was greater than that in normotensive (N) controls (CI: IDH vs. N mean difference 0.10 L/m/m2; CI 95% 0.08 to 0.12; p value <0.001), with no significant clinical difference in Ct. Isolated systolic hypertension (ISH) and divergent systolic-diastolic hypertension (D-SDH) had lower Ct values than nondivergent HT subtype (Ct: divergent vs. nondivergent mean difference −0.20 mL/mmHg; CI 95% −0.21 to −0.19 mL/mmHg; p value <0.001). Additionally, D-SDH displayed the highest TPR (TPR: D-SDH vs. N mean difference 169.8 dyn*s/cm−5; CI 95% 149.3 to 190.3 dyn*s/cm−5; p value <0.001). A new method is provided for the simultaneous assessment of arterial hemodynamics with 24 h ABPM as a single diagnostic tool, which allows a comprehensive assessment of arterial function for hypertension subtypes.

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Section: Discussionsupporting

confidence: 91%

Hemodynamic profiles of arterial hypertension with ambulatory blood pressure monitoring

et al. 2023

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“…The results from this analysis support that E:IVRT values serve as a more reliable predictor of DD in rhesus macaques as opposed to LV‐IVRT alone; the authors suggest that E:IVRT may represent a second valuable index for assessment of diastology in rhesus macaques. Similar to human reports, rhesus macaque E/A measurements are negatively correlated with age and body weight 28,29 . Because our final MLR model could only explain 32.05% of Log_E/A values, there are likely other covariables that could drive a better model for predicating E/A in rhesus macaques that were not included in this study, therefore, an even more robust dataset is warranted for future studies.…”

Section: Discussionsupporting

confidence: 54%

“…28,29 Because our final MLR model could only explain 32.05% of Log_E/A values, there are likely other covariables that could drive a better model for predicating E/A in rhesus macaques that were not included in this study, therefore, an even more robust dataset is warranted for future studies. We report that SPF status is not a significant predictor for measures of diastology, thus, it is unlikely that a role for infectious disease (such as viral myocarditis secondary to common pathogens) in DD of rhesus macaques exist; we confirm that an index of exercise activity (housing configuration) is a notable variable when assessing diastology in rhesus macaques and should be considered in future cardiovascular study designs as increased exercise in the outdoor housing configuration imparts a reduced hazard ratio for diastolic dysfunction.…”

mentioning

confidence: 99%

Sex‐specific differences and predictors of echocardiographic measures of diastolic dysfunction in rhesus macaques (Macaca mulatta)

Rivas

Ueda

Stern

2023

J of Medical Primatology

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BackgroundDiastolic dysfunction in humans is an age‐related process with an overrepresentation in women. In rhesus macaques (Macaca mulatta), the incidence and predictors of diastolic dysfunction have yet to be reported.MethodsData from routine echocardiographic evaluations on clinically healthy rhesus macaques was obtained and used for univariate, bivariate, hypothesis testing, and linear regression statistical analyses interrogating differences and predictors of diastolic function.ResultsRhesus macaques fully recapitulate previously reported human hemodynamic studies. Female monkeys display impaired diastology and are at an increased risk for developing diastolic dysfunction. Age, sex, and proxies of exercise activity are confirmed predictors for measures of diastolic dysfunction, regardless of specific pathogen‐free status.ConclusionsRhesus macaques share common sex‐ and age‐related echocardiographic findings as humans, therefore, serve as a valuable translational nonhuman primate model for future studies of diastolic dysfunction. These findings confirm the importance of sex‐ and age‐matching within future rhesus macaque cardiovascular research.

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“…The PEP, thoracic fluid content (TFC)a measure of preload, and cardiac output (CO) were recorded by impedance cardiography (CardioScreen ® 2000, Medis, Germany). Systemic vascular resistance (SVR) -a measure of afterload -was calculated as a ratio of mean arterial pressure and CO, assuming zero venous pressure at the right atrium (Krzesiński et al 2012, Krzesiński et al 2016, Lasater and Von Rueden 2003, Sodolski and Kutarski 2007, Xiajuan et al 2013. The duration of the PEP was defined as the time interval between R peak of the ECG and the B point of dZ/dt of the ICG and TFC was calculated from the base impedance Z 0 (TFC=1,000/Z 0 ).…”

Section: Data Acquisitionmentioning

confidence: 99%

Preejection Period as a Sympathetic Activity Index: a Role of Confounding Factors

Krohová

Czippelová²,

Turianiková³

et al. 2017

Physiol Res

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In previous studies, one of the systolic time intervals – preejection period (PEP) – was used as an index of sympathetic activity reflecting the cardiac contractility. However, PEP could be also influenced by several other cardiovascular variables including preload, afterload and diastolic blood pressure (DBP). The aim of this study was to assess the behavior of the PEP together with other potentially confounding cardiovascular system characteristics in healthy humans during mental and orthostatic stress (head-up tilt test – HUT). Forty-nine healthy volunteers (28 females, 21 males, mean age 18.6 years (SD=1.8 years)) participated in the study. We recorded finger arterial blood pressure by volume-clamp method (Finometer Pro, FMS, Netherlands), PEP, thoracic fluid content (TFC) – a measure of preload, and cardiac output (CO) by impedance cardiography (CardioScreen® 2000, Medis, Germany). Systemic vascular resistance (SVR) – a measure of afterload – was calculated as a ratio of mean arterial pressure and CO. We observed that during HUT, an expected decrease in TFC was accompanied by an increase of PEP, an increase of SVR and no significant change in DBP. During mental stress, we observed a decrease of PEP and an increase of TFC, SVR and DBP. Correlating a change in assessed measures (delta values) between mental stress and previous supine rest, we found that ΔPEP correlated negatively with ΔCO and positively with ΔSVR. In orthostasis, no significant correlation between ΔPEP and ΔDBP, ΔTFC, ΔCO, ΔMBP or ΔSVR was found. We conclude that despite an expected increase of sympathetic activity during both challenges, PEP behaved differently indicating an effect of other confounding factors. To interpret PEP values properly, we recommend simultaneously to measure other variables influencing this cardiovascular measure.

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The hemodynamic patterns in hypertensive men and women of different age

Cited by 7 publications

References 36 publications

Hemodynamic profiles of arterial hypertension with ambulatory blood pressure monitoring

Hemodynamic profiles of arterial hypertension with ambulatory blood pressure monitoring

Sex‐specific differences and predictors of echocardiographic measures of diastolic dysfunction in rhesus macaques (Macaca mulatta)

Preejection Period as a Sympathetic Activity Index: a Role of Confounding Factors

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