The Hematopoietic Cell Transplant Pharmacist: A Call to Action

Clemmons, Amber B.

doi:10.3390/pharmacy8010003

Cited by 7 publications

(6 citation statements)

References 16 publications

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“…7,8 The main contributions of clinical pharmacists in assisting onco-hematological patients include: evaluating the medical prescription regarding quantity, quality, compatibility, stability and interactions; supportive care management, such as managing anti-infectious therapies; assistance in the transition of care; evaluation of patients regarding the toxicity of chemotherapies and treatment effectiveness, in addition to tracking iatrogenic effects; educating patients, caregivers, as well as health professionals and interns; monitor, evaluate and report results related to treatment to help improve clinical practice. 9–13 Such activities are essential to promote patient safety when using antineoplastic agents and to avoid unnecessary expenses with the use of ineffective drugs for the patient or hospitalizations caused by complications resulting from medication errors that could be avoided. 14–16…”

Section: Introductionmentioning

confidence: 99%

Impact of clinical pharmacy in oncology and hematology centers: A systematic review

Oliveira

Silva

Miranda

et al. 2020

J Oncol Pharm Pract

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Background Oncology and hematology is a complex and specific area that requires monitoring by a multidisciplinary team capable of personalizing the treatment of each patient. Clinical pharmacy services have the potential to contribute significantly to the effective and economical care of cancer patients. Objective To evaluate, synthesize and critically present the available evidence on the impact of the Clinical Pharmacy in the treatment of patients with hematological cancer. Method A review was carried out on the bases PubMed/MEDLINE, LILACS and Google Scholar. The included studies were: studies that evaluated the effects of pharmaceutical interventions in clinical in oncology and hematology services and having as a population patient with hematological cancer. Results 17 studies were selected among 745 identified. 4.771 patients were included, with an average follow-up time of 15.3 months. Patients affected by some type of hematological cancer, undergoing chemotherapy treatment, showed better adherence and continuity when accompanied by a clinical pharmacist, added to this professional in carrying out interventions, provides control of symptoms such as cancer pain, nausea and constipation and, thus, contributes to decrease the length of hospital stay. Conclusion The implementation of a Clinical Pharmacy service in oncology and hematology centers contributes significantly to the effectiveness of pharmacotherapeutic treatment, treatment costs reduction, safety increase in the use of medications and the patient’s quality of life.

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Section: Introductionmentioning

confidence: 99%

Impact of clinical pharmacy in oncology and hematology centers: A systematic review

Oliveira

Silva

Miranda

et al. 2020

J Oncol Pharm Pract

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“…In addition to helping shape new programs for HSCT-related pharmacy services, HSCT pharmacists also hold several key academic positions and provide pharmacy training all around China. Furthermore, education also extends to the training of healthcare providers and trainees, in various pharmacist-led educational services, to optimize collaborative, patient-centered care focused on patient safety 26 . At Shanghai Tongren Hospital, some examples of pharmacist-led training include safe handling of che-motherapy and supportive care management.…”

Section: Educationmentioning

confidence: 99%

Highlights of Pharmacist Roles in Hematopoietic Cell Transplantation and Cellular Therapy

Shi

Tharnpanich

2021

BCT

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Patients with hematological malignancies receiving hematopoietic stem cell transplantation (HSCT) or chimeric antigen receptor (CAR) T-cell therapy are known to have complex pharmacotherapy. To ensure safe and effective care in preventing and managing drug-related problems, pharmacists trained in HSCT and CAR T-cell therapy fulfill various roles in providing care for these patients. With polypharmacy and complex medication regimens, drug interactions are one of the major aspects that pharmacists review regularly to ensure the efficacy of treatment while minimizing toxicity. Pharmacists anticipate various complex drug interactions, understanding the possible mechanisms of drug interactions, and manage these complex drug regimens in patients undergoing HSCT and CAR T-cell therapy. In addition, antimicrobial prophylaxis is also important supportive care for immunocompromised patients. Pharmacists are capable of evaluating the risk of opportunistic infections, anticipating the type of antimicrobial prophylaxis required, and setting a policy with a robust antimicrobial regime. This can promote consistency in patient care and improve patient outcomes in terms of morbidity and mortality associated with opportunistic infections. Lastly, pharmacists are equipped with a skillset to ensure a seamless transition of care, provide education for patients and healthcare providers, promote medication adherence, and contribute to research and quality improvement.

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“…The roles and competencies of the clinical pharmacist involved in HSCT have been defined by several organizations. The American and European societies of Blood and Bone Marrow Transplantation (ASBMT and EBMT) have published recommendations of HSCT clinical pharmacists’ activities and responsibilities ( 11 – 13 ). Both documents endorse pharmacist roles with medication management, patient care, transitions of care, education, and research.…”

Section: Introductionmentioning

confidence: 99%

Chimeric Antigen Receptor T Cell Therapy Management and Safety: A Practical Tool From a Multidisciplinary Team Perspective

et al. 2021

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PurposeThe use process for chimeric antigen receptor T (CAR-T) cell drugs is complex and has been associated with a number of potentially severe complications, which requires management by a multidisciplinary team. Pharmacists are a key element in the team and have roles and responsibilities. Our objective was to develop a structured and practical guide that supports hospital pharmacist responsibilities and defines specific activities in a CAR-T cell therapy program, specifically in Europe.MethodsA literature review was performed, and the recommendations related to pharmacy practice in CAR-T therapy programs were analyzed. A multidisciplinary team was assembled, and meetings were held to address the key tasks in the CAR-T cells’ management process and to create the guide, based on national and international recommendations and in expert’s opinions.ResultsThe multidisciplinary team defined the following key tasks and issued recommendations to improve patient safety, treatment efficacy, and quality: patient selection and evaluation, CAR-T cell drug order to manufacturer, apheresis and material shipment, reception of CAR-T cell drug and storing, CAR-T cell drug prescription and pharmacy verification, CAR-T cell drug thawing and dispensing, CAR-T cell drug administration, patient education, pharmacovigilance and monitoring and outcomes’ record and evaluation. In each task the pharmacist’s role and how it can improve patient care are defined. A checklist was created to guarantee the compliance of standard operating procedures approved in the institution to manage CAR-T cell therapy and as a tool to collect required data for outcomes’ record and evaluation.ConclusionThis article provides a consensus set of safety recommendations regarding CAR-T therapy management in clinical practice, easily implementable by other institutions in the European setting. The guide identifies key steps where the involvement of hospital pharmacists would improve the safety and quality of the process and is a support guide to standardize hospital pharmacists’ responsibilities within the multidisciplinary team.

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The Hematopoietic Cell Transplant Pharmacist: A Call to Action

Cited by 7 publications

References 16 publications

Impact of clinical pharmacy in oncology and hematology centers: A systematic review

Impact of clinical pharmacy in oncology and hematology centers: A systematic review

Highlights of Pharmacist Roles in Hematopoietic Cell Transplantation and Cellular Therapy

Chimeric Antigen Receptor T Cell Therapy Management and Safety: A Practical Tool From a Multidisciplinary Team Perspective

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