The heart rate performance curve and left ventricular function during exercise in patients after myocardial infarction

Pokan, Rochus; Hofmann, Peter; Duvillard, Serge P. von; Beaufort, F; Smekal, Gerhard; Gasser, Robert; Klein, W.; Eber, Bernd; Bachl, Norbert; Schmid, Peter

doi:10.1097/00005768-199810000-00002

Cited by 37 publications

(40 citation statements)

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“…Im Gegensatz zu Gesunden, wo ein deutlicher Anstieg der linksventrikulären Auswurffraktion (LVEF) im Sinne einer Zunahme der myokardialen Funktion von Ruhe bis zum Über-gang von Phase II zu Phase III mit einer anschließenden Plateau-Bildung oder einer geringfügigen Abnahme der LVEF zu beobachten ist [8,13], kommt es bei Patienten mit koronarer Herzerkrankung zu einer deutlichen Abnahme der LVEF wäh-rend Phase III der Energiebereitstellung. Als Zeichen der myokardialen Überlastung kann die LVEF bei maximaler Belastung auf Werte unter den Ruhewert bei gleichzeitiger Zunahme des enddiastolischen Volumens absinken [8,14].…”

Section: E C M O Fü R D Ie K It Te Lt a Sc H E Co Pyr Igh T 20 18unclassified

“…Mit zunehmendem Alter lässt diese Abflachung allerdings in Abhängigkeit zur myokardialen Funktion nach. Demgegenüber findet man bei den meisten Patienten mit koronarer Herzkrankheit und eingeschränkter linksventrikulärer Funktion eine weitere Zunahme der Anstiegsgeschwindigkeit der Belastungsherzfrequenz [14,16].…”

Section: E C M O Fü R D Ie K It Te Lt a Sc H E Co Pyr Igh T 20 18unclassified

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Praxisleitlinien Ergometrie

Wonisch¹,

Berent²,

Klicpera³

et al. 2014

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Section: E C M O Fü R D Ie K It Te Lt a Sc H E Co Pyr Igh T 20 18unclassified

Praxisleitlinien Ergometrie

Wonisch¹,

Berent²,

Klicpera³

et al. 2014

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“…It has been shown that LTP 2 in accordance with AT assessment was significantly related to a change in left ventricular ejection fraction (LVEF) in healthy subjects (Hofmann et al 1994b) and in patients after myocardial infarction (Pokan et al 1998). The relationship of exercise intensity to heart rate (HR) and LVEF was similar in healthy subjects and in patients with a diminished LVEF at intensities above AT.…”

Section: Introductionmentioning

confidence: 94%

“…LTP 2 ) was assessed between 40% of maximal workload (P max ) and P max using linear regression break-point analysis and software PA7000 (Leitner, Graz, Austria) as described previously (Davis et al 1983;Hofmann et al 1994aHofmann et al , 1994bPokan et al 1998). …”

Section: Maximal Testmentioning

confidence: 99%

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Effect of β1-selective adrenergic blockade on maximal blood lactate steady state in healthy men

et al. 2002

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The aim of this study was to compare the effect of taking bisoprolol (B), a highly beta(1)-selective adrenoceptor antagonist to that of a placebo (P) on maximal lactate steady state (MLSS), which reflects the transition from oxidative to partially anaerobic metabolism. Ten healthy male subjects [mean (SD) age 23 (3) years, height 181 (6) cm, body mass 76 (6) kg] randomly received oral P or B (5 mg x day(-1)) for 2 weeks using a double-blind crossover design. In the 2nd week, the subjects performed an incremental cycle ergometer test until exhaustion to determine the second blood lactate turn point (LTP(2)). At regular intervals of 24-48 h, the subjects performed 2-3 steady-state tests to determine the MLSS. During the incremental exercise, heart rate (HR) was significantly lower at rest (15 beats x min(-1)), at LTP(2) (23 beats x min(-1)) and at maximal power output (19 beats x min(-1)) when taking B compared to P. Oxygen pulse was significantly higher taking B and no significant differences were observed for any of the respiratory gas exchange measurements (RGEM) (oxygen consumption, carbon dioxide production, minute ventilation, respiratory exchange ratio), exercise intensity or blood lactate concentration (LA) at baseline, at LTP(2) and at maximal power output. During exercise at constant intensity, significant differences between B and P were found for HR [148 (12) compared to 176 (11) beats x min(-1)] and oxygen pulse [21.8 (1.9) compared to 19.2 (1.6) ml] at MLSS. No difference was found for exercise intensity [216 (18) compared to 218 (18) W], for RGEM, LA [5.3 (1.1) compared to 4.8 (1.5) mmol x l(-1)] and ratings of perceived exertion [18.1 (1.6) compared to 17.4 (1.7)] for B and P at MLSS. In both, the power output at LTP(2) was slightly higher than power output at MLSS (within an intensity step). Commonly measured cardiorespiratory and subjective variables determined during treatment with 5 mg bisoprolol can be used for testing cardiorespiratory fitness and for prescription of training intensity.

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Kompendium Der Kardiologischen Prävention Und Rehabilitation

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The heart rate performance curve and left ventricular function during exercise in patients after myocardial infarction

Abstract: To prevent myocardial overloading, it seems to be useful to determine the HRTP, which indicate the workload where LVEF decreases.

Cited by 37 publications

References 15 publications

Praxisleitlinien Ergometrie

Praxisleitlinien Ergometrie

Effect of β1-selective adrenergic blockade on maximal blood lactate steady state in healthy men

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