The health-related quality of life of ankylosing spondylitis patients assessed by SF-36: a systematic review and meta-analysis

Yang, Xiao; Fan, Dazhi; Xia, Qing; Wang, Mengmeng; Zhang, Xu; Li, Xiaona; Cai, Guoqi; Wang, Li; Xin, Lihong; Xu, Shengqian; Pan, Faming

doi:10.1007/s11136-016-1345-z

Cited by 74 publications

(86 citation statements)

References 80 publications

(48 reference statements)

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“…Health‐related quality of life (HRQoL) is a multi‐domain and subjective concept that encompasses the impact of rheumatic disease and its treatment on a person's perception of his daily life, and it has emerged as important outcome of interest. Some meta‐analyses focusing on rheumatic diseases, such as ankylosing spondylitis, rheumatoid arthritis and Sjögren's syndrome, have integrated some research between disease and HRQoL assessed by the Medical Outcomes Short‐Form‐36 questionnaire (SF‐36). Interestingly, there is no meta‐analysis to assess the impact of systemic sclerosis (SSc) on HRQoL.…”

Section: Introductionmentioning

confidence: 99%

“…The physical component scale (PCS) is calculated by positively weighting the four subscales in the physical domain (PF, RP, BP, GH); and the remaining psychological domain subscales negatively. In contrast, the mental component scale (MCS) is calculated by positively weighting the four mental domain subscales (MH, VT, SF, RE), and negatively weighting the four physical domain subscales …”

Section: Introductionmentioning

confidence: 99%

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The impact of systemic sclerosis on health‐related quality of life assessed by SF‐36: A systematic review and meta‐analysis

et al. 2018

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Objective The purpose of this meta‐analysis was to systematically review the literature to evaluate the impact of systemic sclerosis (SSc) on the health‐related quality of life (HRQoL) assessed by the Medical Outcomes Short‐Form‐36 questionnaire (SF‐36). Methods A systematic literature search was performed on PubMed, Web of Science and Embase until April 2017 to obtain eligible studies. Random effect model was performed to summarize the scores of each domain. Scores from the SF‐36 questionnaire were used as the outcome measurements, and mean differences with 95% confidence intervals were calculated. Results In total, seven studies were eligible for inclusion criteria, comprising 795 SSc patients and 1154 healthy controls. The SF‐36 questionnaire score of each domain (physical function, role physical function, emotional role function, vitality, mental health, social function, body pain, general health) was lower in SSc patients than in healthy controls, meanwhile, physical component scale (PCS) and mental component scale (MCS) scores were all lower in patients with SSc than in healthy controls. Likewise, pooled mean scores of PCS and MCS ranged from 31.20 to 52.80, 37.40 to 68.30, respectively. Additionally, the score of PCS was lower than that of MCS in SSc patients. Conclusions This meta‐analysis showed that SSc patients had lower HRQoL than healthy controls, and SSc had negative influence on the HRQoL of patients. This indicates that clinical workers should pay more attention to SSc patients' HRQoL, so as to improve global health of patients with SSc.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The impact of systemic sclerosis on health‐related quality of life assessed by SF‐36: A systematic review and meta‐analysis

et al. 2018

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“…Future studies are needed to confirm our results and examine the clinical relevance of these findings. Although absenteeism and presenteeism are common in patients with AS, which has been shown to negatively impact HRQoL [4,27], to the best of our knowledge, this is the first real-world study to compare HRQoL and WPAI in patients with successful vs. failing TNFi treatment. The impact of time to switch to another TNFi on HRQoL, and economic and social burden of AS, was not explored in this study but it is an area of interest for future research.…”

Section: Discussionmentioning

confidence: 99%

Unmet needs in ankylosing spondylitis patients receiving tumour necrosis factor inhibitor therapy; results from a large multinational real-world study

Deodhar

Strand²,

Conaghan

et al. 2020

BMC Rheumatol

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Background: Symptoms and comorbidities of ankylosing spondylitis (AS) considerably reduce health-related quality of life (HRQoL) and ability to work. This real-world study assessed rates of tumour necrosis factor inhibitor (TNFi) use and switching, treatment failure, and associations between failing TNFi and HRQoL, work productivity and activity impairment (WPAI). Methods: AS patients and their treating physicians completed questionnaires capturing patient demographics, clinical status, TNFi treatment history, reasons for switching TNFi, HRQoL and WPAI. Current TNFi was determined as "failing" if, after ≥3 months, physician-rated disease severity had worsened, remained severe, was "unstable/ deteriorating", physicians were dissatisfied with disease control and/or did not consider treatment a "success".Results: The analysis included 2866 AS patients from 18 countries. Of 2795 patients with complete treatment data, 916 (32.8%) patients had never received TNFi therapy, 1623 (58.1%) patients were receiving their 1st TNFi and 200 (7.2%) patients had ever received ≥2 TNFi (treatment switch). Primary or secondary lack of efficacy were the commonest reasons for switching, and the mean delay in switching after primary lack of efficacy was 11.1 months. 232 (15.4%) patients on TNFi were currently "failing" who, compared to those with treatment success, reported poorer HRQoL: 5-dimension EuroQoL (EQ-5D-3 L): 0.63 vs. 0.78; Medical Outcomes Study Short-Form Health Survey version 2 (SF-36v2) mental component summary (MCS): 41.8 vs. 46.3; physical component summary (PCS): 40.2 vs. 45.1; impaired work productivity: 46.4% vs. 25.0%; and activity: 44.5% vs. 29.6%; all P < 0.001. Conclusions: Among AS patients, switching TNFi is uncommon and delayed by nearly 1 year despite primary lack of efficacy. Patients currently failing TNFi experience worse physical function, HRQoL and work productivity.

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“…The primary outcomes of interest for this review are the following: (1) physical-related outcomes (incidence of ICU-AW, and standardised physical function-related scale combined 6 min walk test37 and the Medical Research Council scale;38 and (2) health and mental status-related outcomes, using the Hospital Anxiety and Depression Scale39 and standardised Health Related Quality Of Life scale combined with the Medical Outcomes Study 36-Item Short Form Health Survey Physical Function scale40 with EuroQol 5 Dimensions 4142 Since exact PICS criteria do not exist, we will also evaluate overall outcomes after ICU discharge.…”

Section: Methodsmentioning

confidence: 99%

Early rehabilitation for the prevention of postintensive care syndrome in critically ill patients: a study protocol for a systematic review and meta-analysis

et al. 2017

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IntroductionPostintensive care syndrome (PICS) is defined as a new or worsening impairment in cognition, mental health and physical function after critical illness. There is little evidence regarding treatment of patients with PICS; new directions for effective treatment strategies are urgently needed. Early physiotherapy may prevent or reverse some physical impairments in patients with PICS, but no systematic reviews have investigated the effectiveness of early rehabilitation on PICS-related outcomes. The purpose of this systematic review is to evaluate whether early rehabilitative interventions in critically ill patients can prevent PICS and decrease mortality.MethodsWe will conduct a systematic review and meta-analysis of early rehabilitation for the prevention of PICS in critically ill adults. We will search PubMed, EMBASE and the Cochrane Central Register of Controlled Trials for published randomised controlled trials. We will screen search results and assess study selection, data extraction and risk of bias in duplicate, resolving disagreements by consensus. We will pool data from clinically homogeneous studies using a random-effects meta-analysis; assess heterogeneity of effects using the χ2 test of homogeneity; and quantify any observed heterogeneity using the I2 statistic. We will use the Grading of Recommendations Assessment, Development and Evaluation approach to rate the quality of evidence.DiscussionThis systematic review will present evidence on the prevention of PICS in critically ill patients with early rehabilitation.EthicsEthics approval is not required.DisseminationThe results will be disseminated via peer-reviewed journal publication, conference presentation(s) and publications for patient information.Trial registration numberCRD42016039759.

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The health-related quality of life of ankylosing spondylitis patients assessed by SF-36: a systematic review and meta-analysis

Abstract: AS could adversely affect the HRQoL of patients. Measuring HRQoL should be considered as an essential part of the overall assessment of health status of AS patients, which would provide valuable clues for improving the management of disease and making decisions regarding treatment.

Cited by 74 publications

References 80 publications

The impact of systemic sclerosis on health‐related quality of life assessed by SF‐36: A systematic review and meta‐analysis

The impact of systemic sclerosis on health‐related quality of life assessed by SF‐36: A systematic review and meta‐analysis

Unmet needs in ankylosing spondylitis patients receiving tumour necrosis factor inhibitor therapy; results from a large multinational real-world study

Early rehabilitation for the prevention of postintensive care syndrome in critically ill patients: a study protocol for a systematic review and meta-analysis

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