The impact of systemic sclerosis on health‐related quality of life assessed by SF‐36: A systematic review and meta‐analysis

Abstract

Objective The purpose of this meta‐analysis was to systematically review the literature to evaluate the impact of systemic sclerosis (SSc) on the health‐related quality of life (HRQoL) assessed by the Medical Outcomes Short‐Form‐36 questionnaire (SF‐36). Methods A systematic literature search was performed on PubMed, Web of Science and Embase until April 2017 to obtain eligible studies. Random effect model was performed to summarize the scores of each domain. Scores from the SF‐36 questionnaire were used as the outcome measurements, and mean differences with 95% confidence intervals were calculated. Results In total, seven studies were eligible for inclusion criteria, comprising 795 SSc patients and 1154 healthy controls. The SF‐36 questionnaire score of each domain (physical function, role physical function, emotional role function, vitality, mental health, social function, body pain, general health) was lower in SSc patients than in healthy controls, meanwhile, physical component scale (PCS) and mental component scale (MCS) scores were all lower in patients with SSc than in healthy controls. Likewise, pooled mean scores of PCS and MCS ranged from 31.20 to 52.80, 37.40 to 68.30, respectively. Additionally, the score of PCS was lower than that of MCS in SSc patients. Conclusions This meta‐analysis showed that SSc patients had lower HRQoL than healthy controls, and SSc had negative influence on the HRQoL of patients. This indicates that clinical workers should pay more attention to SSc patients' HRQoL, so as to improve global health of patients with SSc.

Validation of the Severity of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome by Other Measures than History: Activity Bracelet, Cardiopulmonary Exercise Testing and a Validated Activity Questionnaire: SF-36

“…A large number of studies have examined the validity of the SF-36 questionnaire, showing that the physical activity subscale discriminates between various diseases and healthy controls [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. In ME/CFS patients Jason et al reported the ability of the different subscales of the SF-36 questionnaire to discriminate CFS patients from healthy controls [ 34 ].…”

Health-related quality of life in patients with systemic sclerosis: evolution over time and main determinants

“…The SHAQ, SF36 and EQ-5D are frequently used to evaluate HRQoL in SSc. The SHAQ has been extensively validated in SSc [ 7 , 8 ], and is designed to measure functional ability or disability in SSc. It is quickly completed by the patients; however, by definition, it does not investigate the psychological aspect of HRQoL [ 7 ].…”

“…Some are specific for distinct organ systems or manifestations, while others are generic and can be applied to SSc and to a broad spectrum of rheumatic and non-rheumatic diseases. Among the generic indices, the Short Form-36 (SF36) and the EuroQol Five-Dimensional descriptive system (EQ-5D) are widely used given their reliability and construct validity [ 7 , 8 ]. The SF36 is a multidimensional questionnaire evaluating both physical and mental functioning.…”

Depression has an impact on disease activity and health‐related quality of life in rheumatoid arthritis: A systematic review and meta‐analysis

“…Depression in patients with RA may therefore be a useful target for interventions aimed at improving subjective health and HRQoL. HRQoL is a multi‐domain and subjective concept that encompasses the impact of rheumatic disease and its treatment on a person's perception of their daily life, and it has emerged as an important outcome of interest . The Short Form‐36 questionnaire (SF‐36) is a generic instrument that has been widely used to measure physical and mental health constructs, which has been widely applied to assess the HRQoL of patients with RA .…”

“…HRQoL is a multi-domain and subjective concept that encompasses the impact of rheumatic disease and its treatment on a person's perception of their daily life, and it has emerged as an important outcome of interest. 9 The Short Form-36 questionnaire (SF-36) is a generic instrument that has been widely used to measure physical and mental health constructs, which has been widely applied to assess the HRQoL of patients with RA. 10 It includes 8 domains: physical function (PF); role physical function (RP); body pain (BP); general health (GH); vitality (VT); social function (SF); role-emotional function (RE); mental health (MH).…”