Predictors of sickness absence in pregnancy: a Danish cohort study by Hansen ML, Thulstrup AM, Juhl M, Kristensen JK, Ramlau-Hansen CH Sickness absence among pregnant women is frequent. Sickness absence has in particular been related to occupational exposures. Little is known of other potentially influencing factors.This large population-based study investigates associations between a number of relevant predictors and risk of sickness absence in pregnancy. We found associations between these predictors and risk of sick leave in pregnancy. Original article Scand J Work Environ Health. 2015;41(2):184-193. doi:10.5271/sjweh.3470 Predictors of sickness absence in pregnancy: a Danish cohort study Objective The aim of this cohort study was to investigate associations between parity, pre-pregnancy body mass index (BMI), assisted reproductive therapy (ART), time to pregnancy (TTP), and engagement in physical exercise and the risk of sickness absence in pregnancy from 10-29 completed pregnancy weeks.Methods Data from 51 874 pregnancies in the Danish National Birth Cohort collected from 1996 until 2002 were linked to the Danish Register for Evaluation of Marginalization. Exposure information was based on questionnaires. Hazard ratios (HR) with 95% confidence intervals (95% CI) were calculated by Cox regression, using time of first episode of sickness absence as the primary outcome.Results Multiparity 1.26 (95% CI 1.10-1.45), overweight 1.13 (95% CI 1.08-1.18), obesity 1.23 (95% CI 1.15-1.31), ART 1.10 (95% CI 1.01-1.20), and TTP >12 months 1.06 (95% CI 0.99-1.13) were associated with higher HR of sickness absence. Physical exercise of >120 minutes per week was associated with lower HR 0.84 (95% CI 0.75-0.95).Conclusion Risk for sickness absence was higher among women who were multiparous, overweight, obese, received ART, and had prolonged TTP, and lower among women engaged in leisure-time physical exercise. Few studies have investigated these associations, and the results should be confirmed in other studies of pregnant women.Key terms assisted reproductive therapy; body mass index; Danish National Birth Cohort; Denmark; parity; physical exercise; time to pregnancy. Sickness absence among pregnant women is frequent (1-5). A number of studies indicate that the amount of sickness absence in pregnancy has increased over the past decades, yet without clear medical explanations (5-8). Factors such as course of pregnancy (9), occupational exposures (10), levels of social benefits (8, 11), and attitudes towards sickness absence, experiences and worries (2) have been associated with levels of sickness absence. However, a number of other factors could potentially also influence sickness absence levels. The combination of work outside the home, domestic duties, and natural physical fatigue increases the total strain among pregnant women, and this may particularly affect sickness absence among multiparous women (9, 12). Body mass index (BMI) could be hypothesized as a risk factor for sickness absence in pregnancy, as BMI is posi...