The Health Benefits of Vitamin D Relevant for Tuberculosis

Škodrić-Trifunović, Vesna; Blanka, Ana; Stjepanović, Mihailo; Ignjatović, Svetlana; Mihailović-Vučinić, Violeta; Šumarac, Zorica; Buha, Ivana; Ilić, Katarina

doi:10.2478/jomb-2014-0032

Cited by 3 publications

(4 citation statements)

References 29 publications

(29 reference statements)

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“…Most of the bone cell types are capable of metabolising 25-OHD to 1,25(OH)2D3 (i.e., the active form of the hormone), to stimulate their own biological functions, such as cell proliferation, maturation, mineralisation and bone resorption ( 12 ). It is generally acknowledged that an adequate vitamin D status is important to minimize the risk of falling in elderly people, and positive effects on falls and muscle function have been shown in community dwelling older individuals ( 13 – 15 ). A recent meta-analysis involving eight trials and 2,426 subjects showed that doses of vitamin D up to 600 IU were ineffective for lowering the risk of falling, whereas higher doses (ranging from 700 to 1,000 IU) reduced such risk by approximately 20% ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Association Of Hyponatremia And Hypovitaminosis D In Ambulatory Adults

Cervellin¹,

Salvagno²,

Bonfanti³

et al. 2015

Journal of Medical Biochemistry

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SummaryBackgroundHyponatremia and vitamin D deficiency are frequent disorders, and both have been associated with gait disturbances, falls and fractures. The aim of this study was to evaluate the existence of an association between serum sodium and vitamin D serum levels.MethodsWe performed a retrospective investigation to establish whether hyponatremia and vitamin D deficiency may be associated in a general population of unselected outpatients. An electronic search was performed in the laboratory information systems of the Hospital of Verona and the Hospital of Parma (Italy), to retrieve combined results for total vitamin D and sodium obtained in all outpatients referred for health check-up in the year 2013.ResultsCombined results of vitamin D and sodium could be retrieved for 5097 outpatients (3859 females and 1238 males; mean age 64±17 years). Vitamin D deficient subjects displayed significantly lower levels of serum sodium (140 versus 141 mmol/L; p<0.001), along with a significantly higher rate of hyponatremia (6.3% versus 5.1%; p=0.037). Accordingly, hyponatremic subjects had significantly lower levels of serum vitamin D (55 versus 60 nmol/L; p=0.015), along with a significantly higher rate of vitamin D deficiency (41.8% versus 36.1%; p=0.030). A highly significant correlation was found between sodium and total vitamin D after adjustment for age and gender (p<0.001).ConclusionsThe results of this study demonstrate for the first time the existence of a significant correlation between the serum levels of sodium and total vitamin D in a general population of unselected outpatients.

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Section: Introductionmentioning

confidence: 99%

Association Of Hyponatremia And Hypovitaminosis D In Ambulatory Adults

Cervellin¹,

Salvagno²,

Bonfanti³

et al. 2015

Journal of Medical Biochemistry

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“…2 While, Vesna Skodric-Trifunovic et al, have shown that despite supplementation of TB chemotherapy with vitamins, the levels of vitamins C and E were not raised as expected, therefore, there is need to determine effective dosage of vitamins for supplementation in MDR-TB patients. 8 .…”

Section: Resultsmentioning

confidence: 99%

“…Vitamin D also has immunomodulatory effects on various cells of the immune system, such as inflammatory dendritic cells, T cells, B cells, plasma cells, macrophages, and antigen-presenting cells (APC), as well as inhibitory effects on the secretion of interleukins. 8,5 Vitamin B12 refers to any of the biologically active forms related to cyanocobalamin. Vitamin B12-dependent enzymes function in core biochemical pathways in Mycobacterium tuberculosis.…”

Section: Introductionmentioning

confidence: 99%

Study of vitamins in pulmonary Tuberculosis

et al. 2019

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Background: In recent years, progress in Tuberculosis (TB) control and eradication has been threatened by the emergence of drug resistant strains of Mycobacterium tuberculosis (MTB). Several studies describe micronutrient malnutrition in TB. This study focuses on the effect of drug resistance and disease progression on levels of various vitamins.Methods: The case control study comprised of 50 normal healthy human volunteers (Control), 50 newly diagnosed TB patients (CAT I) and 50 TB patients showing multi drug resistance (MDR). Recruited subjects were of both genders in age group of 18- 60 years and from different socioeconomic status. Blood serum samples analysed for levels of Vitamin A, Vitamin D, Vitamin E, Vitamin C, Vitamin B12 and Folic acid by using Spectrophotometer, ELISA and Chemiluminescence instruments. Statistical evaluation was done for correlation among variables.Results: The levels of vitamins in TB patients were significantly reduced when compared with controls. Also, MDR-TB patients showed severe malnourished state in comparison to those who were newly diagnosed for the disease.Conclusions: There is a need to provide vitamin supplements in proper sufficient dosage with anti-TB drugs during treatment, which will help fight against the disease and ensure rapid recovery of the patients.

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“…U borbi protiv tuberkuloze u periodu 1800.-1930. godine, pre nego što su antituberkulozni lekovi bili otkriveni, lekari su za lečenje TB upućivali obolele u sanatorijume gde su im savetovali izlaganje suncu (helioterapija -"kupanje suncem") i svežem vazduhu radi bržeg oporavka. U istorijskoj dokumetaciji postoji mnoštvo radova o uticaju vitamina D na brži oporavak od TB, pa je riblje ulje savetovano kao izvanredan izvor 25-hidroksivitamina D, što naučno potvrđuju najnovija istraživanja 2,11 .…”

Section: Lečenje Tuberkuloze Nekada I Sadaunclassified

Tuberculosis: Old and new disease

Škodrić-Trifunović¹

2022

Galenika Med J

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M. tuberculosis is a part of the M. tuberculosis complex and is the causative agent of the infectious disease tuberculosis (TB) in humans. Lungs are the most frequently affected organ at about 90% of all the cases, and extrapulmonary localizations are less often and can affect any organ and tissue. Conventional diagnosis of tuberculosis includes: microscopy of ZiehlNeelsen-stained samples, cultivation of mycobacteria on solid Lowenstein medium, first-line antituberculosis (ATL) sensitivity test for M. tuberculosis. It is often a long long-lasting that lasts two to three months. In the last decades, methods for faster diagnosis of tuberculosis are of great importance and have found a place in practical work in equipped laboratories, and the results are obtained quickly, in a day or two. At the National Reference Laboratory, the Xpert MTB/RIF and GenoType MTBDRplus assays (Hain, Lifescience) are used for this purpose. Standard first-line therapy for the treatment of TB sensitive to antituberculosis drugs lasts 6 months and consists of four drugs: isoniazid, rifampicin, ethambutol and pyrazinamide. In the era of biological therapy, which significantly contributed to the successful treatment of many diseases and the extension of the lifespan, tuberculosis is still actual, due to the immunosuppressive effect of biological therapy, which affects the reactivation of latent infection and the development of active disease. A significantly high risk of TB occurs at the beginning of the administration of biological therapy, especially the first 6 to 12 months, and it is necessary to monitor the clinical course for 3-4 months. Compared to the general population, patients on anti-TNF therapy are 4 to 8 times more likely to develop active TB than those who are not receiving biological therapy. In most countries, screening and treatment of latent tuberculosis (LTBI) has been introduced before starting biological therapy, primarily with drugs from the TNF-alpha antagonists group, with the aim of reducing the incidence of active TB in these patients.

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The Health Benefits of Vitamin D Relevant for Tuberculosis

Cited by 3 publications

References 29 publications

Association Of Hyponatremia And Hypovitaminosis D In Ambulatory Adults

Association Of Hyponatremia And Hypovitaminosis D In Ambulatory Adults

Study of vitamins in pulmonary Tuberculosis

Tuberculosis: Old and new disease

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