The healing effect of licorice extract in acetic acid-induced ulcerative colitis in rat model

Could Licorice prevent Bisphenol A-Induced Biochemical, Histopathological and Genetic Effects in the Adult Male Albino Rats?

“…Previous studies suggested that licorice extract has different bioactive compounds which inhibit NO production and inflammatory cytokine (Chung et al, 2014;Yu et al, 2015). Our results are in accordance with Takhshid et al (2012) and Jung et al (2016) who clarified that licoricederived compounds enhance prostaglandins concentration in the digestive system and this increases secretion of mucus from the stomach which has healing effects.…”

“…Group II (Licorice group): was received the standard diet with licorice at a dose of 150 mg/kg b.w. (body weight) dissolved in water, according to Takhshid et al, (2012).…”

“…Previous studies have reported that licorice root has many medical activities such as antimicrobial, anti-atherosclerotic, antiulcer, anticancer, anti-viral, anti-inflammatory, antioxidant effects (Gafner et al, 2011;Liao et al, 2012;Fu et al, 2013) and free-radical scavenging activities (Di Mambro and Fonseca, 2005). It has been used as a medical raw material to reduce weight gain because of its diuretic effect (Wang et al, 2013), to increase white blood cell count, and as an antidote, a relaxant (Jung et al, 2016) and an expectorant (Takhshid et al, 2012). Rahnama et al (2013) proved that licorice is effective in the detoxification and protection of the liver.…”

The anti-inflammatory activity of licorice, a widely used Chinese herb

“…Depending on previous studies, we found that decreasing the inflammatory factors was the key strategy for licorice to treat inflammation-related disease, such as rheumatoid arthritis , liver oxidative injury (Huo et al 2011), colonic inflammatory response (Takhshid et al 2012) and periodontitis (Farhad et al 2013). Tumour necrosis factor, MMPs, PGE2 and free radicals are four main factors most widely reported among numerous studies related to licorice's anti-inflammatory mechanisms.…”

“…Inflammation responses play an important role in multiple diseases with a high prevalence among population, such as hepatitis (Matsuzaki et al 2007), lung disease (Yang H et al 2013) and Alzheimer's disease (Jayaraman et al 2014). And, they are also centrally related to the pathogenesis of a large number of acute and chronic diseases, such as rheumatoid arthritis (Yang CLH et al 2013), colonic inflammatory response (Takhshid et al 2012) and periodontitis (Farhad et al 2013). However, the conventional therapies for inflammation, including steroids and nonsteroid anti-inflammatory drugs (NSAID) (Sostres et al 2010;Parikh & Scadding 2014;Carrasco-Pozo et al 2016), have shown many side effects and deficiencies.…”