The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals

Piccolo, Stefano; Agius, Eric; Leyns, Luc; Bhattacharyya, Subha; Grunz, Horst; Bouwmeester, Tewis; Robertis, E. M. De

doi:10.1038/17820

Cited by 739 publications

(618 citation statements)

References 24 publications

(13 reference statements)

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“…34 Conversely, Lefty and Cerberus, which do not require Cripto to mediate inhibition of Nodal signaling, are not expressed in melanoma cell lines. 17,32,35,36 Further studies are required to correlate these in vitro findings with patterns of Cripto expression in melanocytic lesions.…”

Section: Discussionmentioning

confidence: 99%

Expression of the embryonic morphogen Nodal in cutaneous melanocytic lesions

Harms

Pouryazdanparast

et al. 2010

Modern Pathology

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Nodal, a potent embryonic morphogen in the transforming growth factor-b family, is a proposed key regulator of melanoma tumorigenicity. However, there has been no systematic study of Nodal expression in melanocytic lesions. We investigated Nodal expression by immunohistochemistry in 269 melanocytic lesions, including compound nevi, dysplastic nevi, congenital nevi, Spitz nevi, melanoma in situ, malignant melanoma including the variant desmoplastic melanoma, and metastatic melanoma. We found that the Nodal expression was significantly increased in malignant lesions (including melanoma in situ, malignant melanoma, and metastatic melanoma) compared with compound nevi, Spitz nevi, and dysplastic nevi. Surprisingly, congenital nevi expressed a level of Nodal comparable with malignant lesions, whereas desmoplastic melanoma showed lower expression than nondesmoplastic malignant melanoma (Po0.05). Deep melanoma (Breslow depth 41 mm) displayed a higher percentage of Nodal-positive tumor cells than did superficial melanoma (Breslow depth r1 mm), although there was no statistical difference in the overall staining intensity (P ¼ 0.18). Melanomas in situ showed a lower level of Nodal expression than did deep melanomas and metastatic melanomas (Po0.05). The low expression of Nodal in normal and dysplastic nevi, and its increasing expression with the progression of malignant lesions, are suggestive of a role for Nodal in melanoma progression.

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Section: Discussionmentioning

confidence: 99%

Expression of the embryonic morphogen Nodal in cutaneous melanocytic lesions

Harms

Pouryazdanparast

et al. 2010

Modern Pathology

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“…Studies on Xenopus embryos suggest that the level of TGF-␤ signaling is directly responsible for the segregation of the endodermal and the mesodermal germ layers. High-level signaling is required for specification of the endoderm, while a lower level of signaling promotes mesoderm formation (Jones et al, 1995;Henry et al, 1996;Clements et al, 1999;Piccolo et al, 1999;Sun et al, 1999;Yasuo and Lemaire, 1999;Gritsman et al, 2000).…”

Section: In Vitro Pancreas-induction Systems Using Undifferentiated Xmentioning

confidence: 99%

In vitro organogenesis from undifferentiated cells in Xenopus

Asashima

Ito

Chan

et al. 2009

Developmental Dynamics

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Amphibians have been used for over a century as experimental animals. In the field of developmental biology in particular, much knowledge has been accumulated from studies on amphibians, mainly because they are easy to observe and handle. Xenopus laevis is one of the most intensely investigated amphibians in developmental biology at the molecular level. Thus, Xenopus is highly suitable for studies on the mechanisms of organ differentiation from not only a single fertilized egg, as in normal development, but also from undifferentiated cells, as in the case of in vitro organogenesis. Based on the established in vitro organogenesis methods, we have identified many genes that are indispensable for normal development in various organs. These experimental systems are useful for investigations of embryonic development and for advancing regenerative medicine. Developmental Dynamics 238:1309 -1320, 2009.

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“…These studies further serve to highlight the idea that the appropriate balance of NO-derivative cell fates (endoderm, mesoderm, and mesendoderm) must be achieved. Balanced Nodal signaling must be achieved in such a manner that the "anterior" ectoderm already in placeboth presumptive neurectoderm and cephalic surface ectoderm-is protected (by Nodal antagonists such as Cerberus and Lefty) from a signaling cascade that converts ectoderm into endoderm and mesoderm (Piccolo et al, 1999;Niehrs, 1999;Thisse et al, 2000;Perea-Gomez et al, 2002;Yamamoto et al, 2004;Kuroda et al, 2004). Protection of the anterior ectoderm appears to be one function of the NO-derived AME (Glinka et al, 1997(Glinka et al, , 1998Shimamiura and Rubenstein, 1997;Bachillier et al, 2000;de Souza and Niehrs, 2000;Kazanskaya et al, 2000;Kiecker and Niehrs, 2001;Mukhopadhyay et al, 2001;Anderson et al, 2002;del Barco Barrantes et al, 2003).…”

Section: From Organizer To Mesendoderm To Pharyngeal Endoderm: Succesmentioning

confidence: 99%

21^st Century neontology and the comparative development of the vertebrate skull

Depew

Simpson

2006

Developmental Dynamics

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Classic neontology (comparative embryology and anatomy), through the application of the concept of homology, has demonstrated that the development of the gnathostome (jawed vertebrate) skull is characterized both by a fidelity to the gnathostome bauplan and the exquisite elaboration of final structural design. Just as homology is an old concept amended for modern purposes, so are many of the questions regarding the development of the skull. With due deference to Geoffroy-St. Hilaire, Cuvier, Owen, Lankester et al., we are still asking: How are bauplan fidelity and elaboration of design maintained, coordinated, and modified to generate the amazing diversity seen in cranial morphologies? What establishes and maintains pattern in the skull? Are there universal developmental mechanisms underlying gnathostome autapomorphic structural traits? Can we detect and identify the etiologies of heterotopic (change in the topology of a developmental event), heterochronic (change in the timing of a developmental event), and heterofacient (change in the active capacetence, or the elaboration of capacity, of a developmental event) changes in craniofacial development within and between taxa? To address whether jaws are all made in a like manner (and if not, then how not), one needs a starting point for the sake of comparison. To this end, we present here a "hinge and caps" model that places the articulation, and subsequently the polarity and modularity, of the upper and lower jaws in the context of cranial neural crest competence to respond to positionally located epithelial signals. This model expands on an evolving model of polarity within the mandibular arch and seeks to explain a developmental patterning system that apparently keeps gnathostome jaws in functional registration yet tractable to potential changes in functional demands over time. It relies upon a system for the establishment of positional information where pattern and placement of the "hinge" is driven by factors common to the junction of the maxillary and mandibular branches of the first arch and of the "caps" by the signals emanating from the distal-most first arch midline and the lamboidal junction (where the maxillary branch meets the frontonasal processes). In this particular model, the functional registration of jaws is achieved by the integration of "hinge" and "caps" signaling, with the "caps" sharing at some critical level a developmental history that potentiates their own coordination. We examine the evidential foundation for this model in mice, examine the robustness with which it can be applied to other taxa, and examine potential proximate sources of the signaling centers. Lastly, as developmental biologists have long held that the anterior-most mesendoderm (anterior archenteron roof or prechordal plate) is in some way integral to the normal formation of the head, including the cranial skeletal midlines, we review evidence that the seminal patterning influences on the early anterior ectoderm extend well beyond the neural plate and are just as importan...

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The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals

Cited by 739 publications

References 24 publications

Expression of the embryonic morphogen Nodal in cutaneous melanocytic lesions

Expression of the embryonic morphogen Nodal in cutaneous melanocytic lesions

In vitro organogenesis from undifferentiated cells in Xenopus

21^st Century neontology and the comparative development of the vertebrate skull

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The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals

Cited by 739 publications

References 24 publications

Expression of the embryonic morphogen Nodal in cutaneous melanocytic lesions

Expression of the embryonic morphogen Nodal in cutaneous melanocytic lesions

In vitro organogenesis from undifferentiated cells in Xenopus

21st Century neontology and the comparative development of the vertebrate skull

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Product

Resources

About

21^st Century neontology and the comparative development of the vertebrate skull