The HBsAg Prevalence Among Blood Donors From Eastern Mediterranean and Middle Eastern Countries: A Systematic Review and Meta-Analysis

Babanejad, Mehran; Izadi, Neda; Najafi, Farid; Alavian, Seyed Moayed

doi:10.5812/hepatmon.35664

Cited by 44 publications

(50 citation statements)

References 60 publications

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“…The HBV prevalence rate significantly varies among different regions: It is less than 1% in America and Western Europe, whilst the highest preva-lence rate is 5% to 10% and can be observed in East Asia and sub-Saharan Africa. A rate between 2% and 5% could be found in the Middle East and the Indian subcontinent (2)(3)(4).…”

Section: Introductionmentioning

confidence: 96%

Prevalence Rate of Hepatitis B Virus in Pregnancy: Implications From a Systematic Review and Meta-Analysis of Studies Published From 2000 to 2016

et al. 2018

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Background: Hepatitis B Virus (HBV) is one of the most serious infectious diseases and represents a major global health issue worldwide. It can be transmitted vertically and horizontally through contact with infected blood or body fluids. More attention to HBV infection in pregnancy is needed due to high risk of chronicity when transmitted to infants during delivery. Objectives: A comprehensive review of the HBV prevalence rate in pregnant females taking into account different geographical areas and socio-economic status is still lacking. This would be of crucial importance for HBV prevention and control programs. As such, this systematic review and meta-analysis was conducted focusing on HBV prevalence rate in pregnant females from different parts of the world. Methods: Different electronic databases, including Embase, PubMed/MEDLINE, Scopus, and ISI/Web of Science were searched from January 1st 2000 to July 31st 2016, using relevant keywords, such as "prevalence" or "seroprevalence" or "epidemiology" and "pregnancy" or "pregnant" or "antenatal" in combination with "hepatitis B virus" or "HBV" with no language restrictions. The study protocol of this systematic review was deposited at the "International Prospective Register of Systematic Reviews" and registered as CRD42016041985. Results: After scrutinizing all the extant scholarly literature from 2000 to 2016, this study found 222 relevant articles. The overall HBV prevalence rate in pregnant females worldwide was estimated using a random-effect model, giving a value of 3% (95% confidence interval or CI 2% -4%). Heterogeneity between studies was significantly high (I 2 = 99.9%, P < 0.0001). The clinical and epidemiological burden was higher in developing countries. Conclusions:This suggests that despite the recent scientific advancements and the clinical progress that has occurred in anti-viral therapy, HBV still represents a major issue worldwide, especially in underdeveloped countries. The key strategies for preventing transmission from pregnant females to their fetuses are through early birth dose and infant vaccination, as well as by the use of hepatitis B immunoglobulin (HBIG) and the screening and diagnosis of mothers at high risk and the subsequent use of anti-viral agents during pregnancy in order to reduce maternal DNA concentrations down to undetectable concentrations. Health authorities should effectively implement these approaches to better control HBV in pregnancy.

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Section: Introductionmentioning

confidence: 96%

Prevalence Rate of Hepatitis B Virus in Pregnancy: Implications From a Systematic Review and Meta-Analysis of Studies Published From 2000 to 2016

et al. 2018

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“…Based on the World Health Organization (WHO) reports, the prevalence of HBV, HCV, and HIV infections among blood donors from different parts of the world ranges 0.008% to 6.08%, 0.004% to 1.96%, and 0.0004% to 2%, respectively (7). The overall prevalence of these three viral infections was reported to be 0.7%, 0.5%, and 0.004%, respectively, among Iranian blood donors (8)(9)(10). In many countries, a significant decrease in the transmission of these viruses occurred when some measures were taken including the meticulous pre-transfusion serological screening of donated blood and the exclusion of high-risk groups from blood donation (1,11 the risk of transfusion-transmitted infections (TTIs), several blood safety strategies are applied at Iranian blood transfusion centers.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Viral Transfusion-Transmitted Infections (TTIs) Among Resident and Pilgrim Blood Donors in Mashhad, 2011

2019

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Background: Mashhad is a large pilgrimage city with over 20 million pilgrims and tourists annually. Some pilgrims donate their blood voluntarily during the pilgrimage. Objectives: The present study aimed to compare the prevalence of viral transfusion-transmitted infections (TTIs) between resident and pilgrim blood donors in Mashhad. Methods: We reviewed the records of all blood donors in Mashhad blood centers in 2011. The demographic data and the prevalence of TTIs, including HBV, HCV, HIV, and HTLV-1, were compared between 42821 donors from Mashhad and 15219 donors from other cities of Iran. The data were analyzed using Microsoft Excel 2010 and Epi-Info 6.0 software. Results:The mean age of residents and pilgrims was 34.6 ± 9.9 and 34.2 ± 10 years, respectively. The male to female ratio in the first group was higher than that in the second group (13.1 and 6.6, respectively). One-third of the residents and nearly two-thirds of the pilgrims were first-time blood donors. The most prevalent TTIs among the residents were HTLV-1 (0.39%) and HBV (0.33%); however, the frequencies of these infections were 0.24% and 0.57% among the pilgrims, respectively. The seroprevalence of HCV infection was 0.054% and 0.072% in the first and second groups, respectively. The HIV infection was observed only in one donor from Mashhad. Conclusions: A low prevalence of TTIs, particularly HCV and HIV infections, was found among blood donors from all parts of Iran. A higher prevalence of HTLV-1 infection among Mashhad donor population than among donors from other parts of Iran verified the virus endemicity in this region.

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“…; la prevalencia reportada de HBsAg fue de 2% en los países de la Región Este del Mediterráneo y Medio Oriente (3) . El Perú es considerado entre los países de endemicidad…”

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Marcadores de infección para hepatitis viral en donantes de sangre de un hospital nacional de Lima metropolitana

Morales

Fuentes-Rivera

Delgado-Silva

et al. 2017

Rev Peru Med Exp Salud Publica

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RESUMENEl objetivo del estudio fue determinar la frecuencia de marcadores de infección para hepatitis B, hepatitis C y conocer los factores asociados en los donantes de sangre. El estudio se realizó con datos del registro de donantes de un hospital público de Lima. De 28 263 sujetos analizados entre 2012 y 2015, el 0,6% (n=156) fue reactivo para HBsAg; 5,2% (n=1465) para anti-HBc, y 0,8% (n=232) para Anti-HVC. Los resultados positivos para HBsAg (p=0,319) y anti-HVC (p=0,037) fueron en mayor proporción en los donantes voluntarios. Los resultados positivos para HBsAg y anti-HBc fueron en mayor proporción en las personas de 50 a más años de edad. Los donantes voluntarios fueron en mayor proporción en los sujetos menores de 20 años (p<0,001). En conclusión, la reactividad a los marcadores de infección para hepatitis está asociado a la donación voluntaria y al grupo de edad de los donantes. Palabras clave: Hepatitis B; Hepatitis C; Donantes de sangre (Fuente: DeCS, BIREME). VIRAL HEPATITIS INFECTION MARKERS AMONG BLOOD DONOR IN A NATIONAL HOSPITAL OF METROPOLITAN LIMA ABSTRACTThe aim of the study was to determine the frequency of infection markers for hepatitis B and hepatitis C and to identify associated factors in blood donors. The study was carried out using data obtained from blood donor medical records collected in a public hospital in Lima. Of 28,263 individuals analyzed between 2012 and 2015, 0.6% (n=156) were reactive for HBsAg; 5.2% (n=1,465), for anti-HBc; and 0.8% (n=232), for anti-HVC. Positive results for HBsAg (p=0.319) and anti-HVC (p=0.037) were more common in voluntary donors. For HBsAg and anti-HBc, positive results were more common in individuals aged 50 years or older. The number of voluntary donors was higher among individuals younger than 20 years (p<0.001). The study indicates that reactivity to hepatitis infection markers is associated with voluntary donation and the age group of blood donors. Key words: Hepatitis B; Hepatitis C; Blood donors (Source: MeSH, NLM). INTRODUCCIÓNLa hepatitis viral, una pandemia silenciosa que genera una enorme carga para los sistemas de salud, es la octava causa de mortalidad en todo el mundo. Se estima que cada año ocasiona 1,4 millones de muertes por infección aguda, cáncer hepático y cirrosis relacionadas con la hepatitis, de los cuales el 55 % son atribuidos al virus de la hepatitis B (VHB) y el 35% al virus de la hepatitis C (VHC) (1) . A nivel mundial, se estima que 2000 millones de personas están afectadas por el VHB, de ellas, 240 millones padecen infección hepática crónica por el VHB y corren el riesgo de fallecer por cirrosis o carcinoma hepatocelular, enfermedades que, se calcula, provocan de 500 000 a 700 000 muertes por año en el mundo (2) .La prevalencia del VHB es variable según las regiones, se estima de 5 a 8% en África y de 2 a 4% en Sudamérica (2)

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The HBsAg Prevalence Among Blood Donors From Eastern Mediterranean and Middle Eastern Countries: A Systematic Review and Meta-Analysis

Cited by 44 publications

References 60 publications

Prevalence Rate of Hepatitis B Virus in Pregnancy: Implications From a Systematic Review and Meta-Analysis of Studies Published From 2000 to 2016

Prevalence Rate of Hepatitis B Virus in Pregnancy: Implications From a Systematic Review and Meta-Analysis of Studies Published From 2000 to 2016

Frequency of Viral Transfusion-Transmitted Infections (TTIs) Among Resident and Pilgrim Blood Donors in Mashhad, 2011

Marcadores de infección para hepatitis viral en donantes de sangre de un hospital nacional de Lima metropolitana

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