The Hardy–Zuckerman 2-FeSV, a new feline retrovirus with oncogene homology to Abelson-MuLV

Besmer, Peter; Hardy, W. D.; Zuckerman, Enid; Bergold, Peter J.; Lederman, Lynne; Snyder, Harry W.

doi:10.1038/303825a0

Cited by 68 publications

(34 citation statements)

References 21 publications

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“…Expression of a shorter, 2.8 kb PDGF-B/c-sis transcript, which lacks the 5' UTS, has been described in cultured human umbilical vein endothelial cells (HUVECs;Fen and Daniel, 1991). PDGF-B/c-sis sequences transduced by simian sarcoma and ParodiIrgens feline sarcoma viruses also lack the translation inhibitory 5' UTS (Besmer et al, 1983;Doolittle et al, 1983;Water®eld et al, 1983). The absence of the 5' UTS is thought to contribute to a more e cient translation of the PDGF-B/c-sis gene products in these cells.…”

Section: Introductionmentioning

confidence: 99%

Normal developing rat brain expresses a platelet-derived growth factor B chain (c-sis) mRNA truncated at the 5′ end

et al. 1998

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Section: Introductionmentioning

confidence: 99%

Normal developing rat brain expresses a platelet-derived growth factor B chain (c-sis) mRNA truncated at the 5′ end

et al. 1998

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“…A subset of this region contains sequences highly homologous to tyrosine kinases encoded by other transforming genes (10,22). Since the initial isolation of A-MuLV, one other transduction event involving the c-abl gene has been reported in the characterization of the Hardy-Zuckerman 2 feline sarcoma virus (3). The gene product expressed by this defective feline retro-* Corresponding author.…”

mentioning

confidence: 99%

Activation of the c-abl oncogene by viral transduction or chromosomal translocation generates altered c-abl proteins with similar in vitro kinase properties.

Davis¹,

Konopka²,

Witte³

1985

Mol. Cell. Biol.

153

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The v-abl protein of Abelson murine leukemia virus is a tyrosine-specific kinase. Its normal cellular homolog, murine c-abl, does not possess detectable tyrosine kinase activity in vitro. Previously, we have detected tyrosine kinase activity in vitro for an altered c-abl gene product (c-abl P210) in the K562 human chronic myelogenous leukemia cell line. The expression of this variant c-abl gene product correlates with chromosomal translocation and amplification of the c-abl gene in K562 cells. Like v-abl, c-abl P210 is a fusion protein containing non-abl sequences near the amino terminus of c-abl. We compared the in vitro tyrosine kinase activity of c-abl P210 with that of wild-type murine v-abl. The remarkable similarities of these two proteins with respect to cis-acting autophosphorylation, trans-acting phosphorylation of exogenous substrates, and kinase inhibition, using site-directed abl-specific antisera, suggested that c-abl P210 could function similarly to v-abl in vivo. In addition, c-abl P210 possessed an associated serine kinase activity in immunoprecipitates. The serine kinase activity was not inhibited by site-directed, abl-specific antisera that inhibit the tyrosine kinase activity, suggesting that the serine kinase activity is not an intrinsic property of c-abl P210. Thus, the activation of the c-abl gene in a human leukemia cell line may have functional consequences analogous to activation of the c-abl gene in Abelson murine leukemia virus.

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“…7 and 8). c-abl is also the transduced homolog of the transforming genes of Abelson murine leukemia virus (9,10) and Hardy-Zuckerman 2 feline sarcoma virus (11), replication-defective retroviruses that cause aggressive lymphomas in mice and fibrosarcomas in cats, respectively. In each of these cases, the activated forms of c-abl have in common an elevated level of tyrosine kinase activity (5,12).…”

mentioning

confidence: 99%

The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.

Kruh

Perego

Miki

et al. 1990

Proc. Natl. Acad. Sci. U.S.A.

146

129

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BiochemistryThe complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases ABSTRACTWe have previously described partial genomic sequences of arg, a human gene related to c-abl, andshown that it is expressed as a 12-kilobase transcript and is located at chromosome position lq24-25. In this study we elucidate the complete coding sequence of ar by characterization of cDNA clones. Analysis of the predicted amino acid sequence of arg revealed that it is indeed closely related to that of c-abl. The two proteins are strikingly similar with regard to overall structural architecture as well as the amino acid sequences of their tyrosine kinase and src homologous 2 and 3 domains. In addition, arp, like c-abl, is expressed as two transcripts that result from a process of alternative splicing and encode alternative protein forms that differ only in their amino termini. The two genes define the Abelson subfamily of cytoplasmic tyrosine kinases and share a common homolog in Drosophila.

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The Hardy–Zuckerman 2-FeSV, a new feline retrovirus with oncogene homology to Abelson-MuLV

Cited by 68 publications

References 21 publications

Normal developing rat brain expresses a platelet-derived growth factor B chain (c-sis) mRNA truncated at the 5′ end

Normal developing rat brain expresses a platelet-derived growth factor B chain (c-sis) mRNA truncated at the 5′ end

Activation of the c-abl oncogene by viral transduction or chromosomal translocation generates altered c-abl proteins with similar in vitro kinase properties.

The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.

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