The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.

Kruh, Gary D.; Perego, R; Miki, Toru; Aaronson, Stuart A.

doi:10.1073/pnas.87.15.5802

Cited by 146 publications

(130 citation statements)

References 40 publications

Supporting

Mentioning

129

Contrasting

Order By: Relevance

“…Only a few spermatids were seen within the lumen. The ®nding that certain Abl 7/7 mice produce no spermatozoa while others exhibit decreased production (Kruh et al, 1990), that can suppress loss of cAbl function. Taken together with the histochemistry studies, these ®ndings demonstrate defects in meiotic progression beyond the pachytene stage in Abl 7/7 mice.…”

Section: Resultsmentioning

confidence: 99%

Functional role for the c-Abl tyrosine kinase in meiosis I

et al. 1998

View full text Add to dashboard Cite

The c-Abl tyrosine kinase is activated by ionizing radiation and certain other DNA-damaging agents. The DNA-dependent protein kinase (DNA ± PK) and the ataxia telangiectasia mutated (ATM) gene product, e ectors in the DNA damage response, contribute to the induction of c-Abl activity. The present study demonstrates that c-Abl is expressed in mouse and rat testes, and predominantly in pachytene spermatocytes of meiosis I. The results also demonstrate that c-Abl interacts directly with meiotic chromosomes. In concert with a requirement for c-Abl at the pachytene stage, we show that, in contrast to wild-type mice, testes from Abl 7/7 mice exhibit defects in spermatogenesis. These ®ndings provide the ®rst demonstration that c-Abl plays a functional role in meiosis.

show abstract

Section: Resultsmentioning

confidence: 99%

Functional role for the c-Abl tyrosine kinase in meiosis I

et al. 1998

View full text Add to dashboard Cite

show abstract

“…The N-terminal 60 kDa is homologous to c-Src and other Src-family members, but c-Abl has a large unique C-terminal domain of ~90 kDa. There is one known homologue of c-abl, identified by low-stringency screening of genomic DNA, denoted abl-related gene (arg) 2 . The arg gene product shares considerable structural and sequence homology with c-Abl in the N-terminal portion, but the C-terminal domain of Arg is fairly divergent from Abl (Fig.…”

Section: Pii: S0962-8924(99)01549-4mentioning

confidence: 99%

Cycling, stressed-out and nervous: cellular functions of c-Abl

Etten

1999

Trends in Cell Biology

285

243

View full text Add to dashboard Cite

“…A 90 kDa C-terminal domain includes potential actin-and DNA-binding domains, a nuclear localization signal, and binding sites for the adapter proteins Crk/CRKL, Grb2 and Nck Ren et al, 1994). c-Abl and the Arg kinase (product of the abl related gene) share 90 ± 95% identity in the SH2, SH3 and catalytic domains, whereas their C-terminal parts are much more diverse, with only approximately 30% overall identity (Kruh et al, 1986(Kruh et al, , 1990.…”

Section: Introductionmentioning

confidence: 99%

The leukaemic oncoproteins Bcr-Abl and Tel-Abl (ETV6/Abl) have altered substrate preferences and activate similar intracellular signalling pathways

Voß¹,

Posern²,

Hannemann

et al. 2000

Oncogene

View full text Add to dashboard Cite

Inappropriate activation of Abl family kinases plays a crucial role in di erent human leukaemias. In addition to the well known oncoproteins p190Bcr-Abl and p210Bcr-Abl, Tel-Abl, a novel fusion protein resulting from a di erent chromosomal translocation, has recently been described. In this study, the kinase speci®cities of the Bcr-Abl and Tel-Abl proteins were compared to the physiological Abl family kinases c-Abl and Arg (abl related gene). Using short peptides which correspond to the target epitopes in known substrate proteins of Abl family kinases, we found a higher catalytic promiscuity of Bcr-Abl and Tel-Abl. Similar to Bcr-Abl, Tel-Abl was found in complexes with the adapter protein CRKL. In addition, c-Crk II and CRKL are tyrosine phosphorylated and complexed with numerous other tyrosine phosphorylated proteins in Tel-Abl expressing Ba/F3 cells. GTPase analysis with a Ras´GTP-speci®c precipitation assay showed constitutive elevation of GTPloaded Ras in cells expressing the leukaemic Abl proteins. The mitogenic MAPK/Erk kinases as well as Akt/PKB, a kinase implicated to negatively regulate apoptosis, were also constitutively activated by both BcrAbl and Tel-Abl. The results indicate that the leukaemic Abl-fusion proteins have catalytic speci®cities di erent from the normal kinases c-Abl and Arg and that Tel-Abl is capable to activate at least some pathways which are also upregulated by Bcr-Abl.

show abstract

The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.

Cited by 146 publications

References 40 publications

Functional role for the c-Abl tyrosine kinase in meiosis I

Functional role for the c-Abl tyrosine kinase in meiosis I

Cycling, stressed-out and nervous: cellular functions of c-Abl

The leukaemic oncoproteins Bcr-Abl and Tel-Abl (ETV6/Abl) have altered substrate preferences and activate similar intracellular signalling pathways

Contact Info

Product

Resources

About