The Hantaviruses, Etiologic Agents of Hemorrhagic Fever with Renal Syndrome: A Possible Cause of Hypertension and Chronic Renal Disease in the United States
“…However, the data in this study indicate that individuals with past PUV infection do not have an increased risk for cardiovascular disease, hypertension, myocardial infarction or diabetes mellitus. This is in contrast to recent reports suggesting that previous hantavirus infection is associated with hypertension and chronic renal disease [22][23][24]. Prospective longitudinal studies are needed to establish a definite causal relationship.…”
SUMMARYA stratified and randomly-selected population sample was identified in 1990 in order to study the seroprevalence of nephropathia epidemica (haemorrhagic fever with renal syndrome) in Northern Sweden. Sera from 1538 subjects (750 men, 788 women), 25-64 years of age, were analysed for the presence of Puumala virus (PUV) specific-IgG by the indirect immunofluorescence antibody test. Specific IgG was detected in sera from 83 subjects (54%). Men and women had similar seroprevalence rates. The highest seroprevalences were found in subjects 55 years or older (8-0 %) and among farmers and forestry workers (15-9 %). The geographic distribution of seropositive individuals was uneven and there were significantly more seropositive persons in rural than in urban areas (P < 0 05).
“…However, the data in this study indicate that individuals with past PUV infection do not have an increased risk for cardiovascular disease, hypertension, myocardial infarction or diabetes mellitus. This is in contrast to recent reports suggesting that previous hantavirus infection is associated with hypertension and chronic renal disease [22][23][24]. Prospective longitudinal studies are needed to establish a definite causal relationship.…”
SUMMARYA stratified and randomly-selected population sample was identified in 1990 in order to study the seroprevalence of nephropathia epidemica (haemorrhagic fever with renal syndrome) in Northern Sweden. Sera from 1538 subjects (750 men, 788 women), 25-64 years of age, were analysed for the presence of Puumala virus (PUV) specific-IgG by the indirect immunofluorescence antibody test. Specific IgG was detected in sera from 83 subjects (54%). Men and women had similar seroprevalence rates. The highest seroprevalences were found in subjects 55 years or older (8-0 %) and among farmers and forestry workers (15-9 %). The geographic distribution of seropositive individuals was uneven and there were significantly more seropositive persons in rural than in urban areas (P < 0 05).
“…They noted that 2-5 years after apparent recovery from HFRS, 7 of 13 patients had acquired hyposthenuria, and 2 of 13 had developed hypertensive vascular disease. In addition, they reported 1 case of chronic glomerulonephritis and 2 cases of pyelonephritis among 31 [44]. An increased prevalence of hantavirus antibody in patient populations with renal disease also has been reported from countries where HFRS is rare or unreported, such as Ireland [45].…”
“…Rats have carried hantaviruses virtually worldwide (29). Aedes albopictus (the Asian tiger mosquito) was introduced into the United States, Brazil, and parts of Africa in shipments of used tires from Asia (30).…”
Section: International Travel and Commercementioning
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