Infection with a Ratborne Hantavirus in US Residents Is Consistently Associated with Hypertensive Renal Disease

Glass, Gregory E.; Watson, Alan J.; LeDuc, James W.; Kelen, Gabor D.; Quinn, Thomas C.; Childs, James E.

doi:10.1093/infdis/167.3.614

Cited by 108 publications

(44 citation statements)

References 29 publications

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“…In contrast to reports from other countries which demonstrated serological evidence of HV infections in individuals with chronic renal disease [9][10][11][12][13], we only found evidence for HV infection in 1 out of 642 haemodialysis and renal transplant patients. Furthermore, the seroprevalence of HV infections in patients suspected of leptospirosis (1 %) was slightly lower than the incidence of acute leptospirosis in this group (3 %), which indicates the relative importance of the HV infection in The Netherlands.…”

Section: Discussioncontrasting

confidence: 99%

“…Seroepidemiological studies in Asia, Europe and the USA have demonstrated HV-specific antibodies in the sera of individuals, such as farmers and army personnel, at high risk of contact with feral rodents [5][6][7][8][9][10]. Recently, serological evidence of HV infection was also found in patients with chronic renal failure, haemodialysis patients, and in renal transplant candidates [11][12][13]. Furthermore, HV-specific serum antibodies have been found in individuals with acute respiratory disease and in patients suspected of acute leptospirosis [3,6,8].…”

Section: Introductionmentioning

confidence: 99%

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Hantavirus infections in The Netherlands: epidemiology and disease

et al. 1995

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SUMMARYA serological survey for the prevalence of hantavirus infections in The Netherlands was carried out on > 10000 sera, from selected human populations, and different feral and domestic animal species. Hantavirus-specific antibodies were found in about 1 % of patients suspected of acute leptospirosis, 10% of patients with acute nephropathia, and in less than 011% haemodialysis and renal transplant patients. Among individuals with a suspected occupational risk, 6 % of animal trappers, 4 % of forestry workers, 2 % of laboratory workers and 0-4 % of farmers were seropositive. The majority of the seropositive individuals lived in rural and forested areas. The main animal reservoir of the infection was shown to be the red bank vole (Clethrionomys glareolus). Epidemiological, clinical and laboratory findings seen in serologically confirmed human cases were similar to those associated with nephropathia epidemica.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hantavirus infections in The Netherlands: epidemiology and disease

et al. 1995

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“…However, the data in this study indicate that individuals with past PUV infection do not have an increased risk for cardiovascular disease, hypertension, myocardial infarction or diabetes mellitus. This is in contrast to recent reports suggesting that previous hantavirus infection is associated with hypertension and chronic renal disease [22][23][24]. Prospective longitudinal studies are needed to establish a definite causal relationship.…”

Section: Resultscontrasting

confidence: 79%

Prevalence of serum IgG antibodies to Puumala virus (haemorrhagic fever with renal syndrome) in Northern Sweden

et al. 1994

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SUMMARYA stratified and randomly-selected population sample was identified in 1990 in order to study the seroprevalence of nephropathia epidemica (haemorrhagic fever with renal syndrome) in Northern Sweden. Sera from 1538 subjects (750 men, 788 women), 25-64 years of age, were analysed for the presence of Puumala virus (PUV) specific-IgG by the indirect immunofluorescence antibody test. Specific IgG was detected in sera from 83 subjects (54%). Men and women had similar seroprevalence rates. The highest seroprevalences were found in subjects 55 years or older (8-0 %) and among farmers and forestry workers (15-9 %). The geographic distribution of seropositive individuals was uneven and there were significantly more seropositive persons in rural than in urban areas (P < 0 05).

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“…Prior to 1993, only two hantaviruses had been described in North America, Prospect Hill and Seoul virus. 1,2 In 1993, an outbreak of a respiratory illness of unknown etiology in the Four Corners region of the southwestern United States led to the isolation and identification of Sin Nombre virus (SNV) and to the description of hantavirus pulmonary syndrome (HPS). 3 The primary reservoir of SNV was determined to be the deer mouse (Peromyscus maniculatus).…”

Section: Introductionmentioning

confidence: 99%

Antibody to sin nombre virus in rodents associated with peridomestic habitats in west central Montana.

Kuenzi¹,

Douglass²,

White³

et al. 2001

The American Journal of Tropical Medicine and Hygiene

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Abstract. Most human cases of hantavirus pulmonary syndrome are acquired in the peridomestic environment, yet studies of the ecology and infection dynamics in the reservoir host, the deer mouse (Peromyscus maniculatus), have focused on sylvan populations. We describe a 2.5-year study of hantavirus infection in rodents associated with peridomestic habitats in west central Montana. Antibodies reactive with Sin Nombre virus (SNV) were found in five species. Overall SNV antibody prevalence was highest among deer mice (25% of individuals tested). As has been demonstrated for sylvan populations, the antibody-positive component of the deer mouse population consisted of a higher proportion of adults and males. However, the prevalence of antibodies to SNV was higher in this study than has been reported in most sylvan studies. The average monthly proportion of deer mouse blood samples with antibodies to SNV ranged from approximately 20% to 25% and was highest in the late spring/early summer. The higher SNV antibody prevalence in peridomestic compared with sylvan settings may be related to behavioral differences and/or potentially longer survival of the virus deposited inside buildings. Peridomestic settings presented higher concentrations of virus and may present a higher risk of human infection than do sylvan settings.

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Infection with a Ratborne Hantavirus in US Residents Is Consistently Associated with Hypertensive Renal Disease

Cited by 108 publications

References 29 publications

Hantavirus infections in The Netherlands: epidemiology and disease

Hantavirus infections in The Netherlands: epidemiology and disease

Prevalence of serum IgG antibodies to Puumala virus (haemorrhagic fever with renal syndrome) in Northern Sweden

Antibody to sin nombre virus in rodents associated with peridomestic habitats in west central Montana.

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