The Handbook of Radiopharmaceuticals

Effect of antimalarial drugs on the bioavailability of the methylenediphosphonic acid labeled with technetium99m (99mTc-MDP) in Wistar rats

“…In nuclear medicine, these radiopharmaceuticals are employed in the study of blood flow, metabolism, morphology of an organ and to evaluate the drug formulation and drug delivery systems (Chandra, 1998;Perkins and Frier, 1999). According to Hesselewood and Leung (1994), Owunwanne and Collaborators (1995) and Saha (1998), one of these radiopharmaceuticals is the well known methylenediphosphonic acid labeled with 99m Tc ( 99m Tc-MDP), which is used to perform bone scintigraphy (Owunwanne et al, 1995;Saha, 1998). The 99m Tc-MDP has been used for bone scanning and for the localization of primary bone tumours, metastatic tumours and metabolic bone diseases.…”

“…Many authors have been studying the drug interaction as an important factor that can alter the behavior of the radiopharmaceuticals in different organs and tissues of the animal models (Owunwanne et al, 1998;Mattos et al, 1999;Xavier Holanda et al, 2002;Amorim et al, 2003;Britto et al 2004;. Frequently, this phenomenon is responsible for modification of the bioavailability of the radiopharmaceutical (Owunwanne et al, 1995;Hung et al, 1996;Xavier Holanda et al, 2002;Gomes et al, 2002). Thus, the nuclear medicine practices have increased continually in recent decades.…”

Biodistribution of 99Mo in rats

“…Figures 1 and 2 show respectively the distribution of free molybdenum and molybdenum combined to MDP in planar chromatography using 0.9% NaCl solution and Propanone as mobile phases. It is known that MDP presents high affinity to NaCl 0.9% solution as well as to technetium in the form of pertechnetate (Owunwanne, 1995). Such characteristic is not observed in molybdenum, which presents higher affinity to the medium.…”

“…(Owunwanne, 1995). Molybdenum decays by beta emission to 99m Tc (87%) and 99 Tc (13%), emitting photons of 740 and 778 keV and has a half-life of 66 h (LBNL, 2005 Tc-MDP for radionuclide imaging include its rapid clearance from plasma and its high urinary excretion, which contribute to the high contrast between bone and soft tissue.…”

Effects of clove (Caryophyllus aromaticus L.) on the labeling of blood constituents with technetium-99m and on the morphology of red blood cells

“…(Hesslewood and Leung, 1994;Owunwanne et al, 1995;Sampson, 1999). Blood constituents labeled with 99mTc have been used in several clinical examinations (Saha, 2004) and also as an experimental assay on an attempt to verify the effect of drugs ).…”