The H1- and H2-histamine blockers chlorpheniramine and ranitidine applied to the nucleus basalis magnocellularis region modulate anxiety and reinforcement related processes

Privou, Caroline; Knoche, Anja; Hasenöhrl, Rüdiger U.; Huston, Joseph P.

doi:10.1016/s0028-3908(98)00087-2

Cited by 75 publications

(39 citation statements)

References 88 publications

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“…We also reported an anxiogenic effect following injection of histamine into the central nucleus of the amygdala in our previous study [37] . In agreement with our data regarding the anxiolytic effect of pyrilamine, it has been reported that administration of chlorpheniramine, an H 1 receptor antagonist, into the nucleus basalis magnocellularis [14] and cerebroventricle [38] had anxiolytic effects in rats. Moreover, Yanai et al [39] reported that mice lacking H 1 receptors showed prolonged transfer latency in the light/dark box test, indicating that mutant mice were less fearful than wild-type mice.…”

Section: Discussionsupporting

confidence: 93%

“…Moreover, it has been demonstrated that experimental anxiety can be achieved by coadministration of a neuronal histamine releaser (thioperamide) with a histamine agonist (betahistine) [32] . The anxiogenic effect of histamine and related compounds has also been reported following injection into some brain regions, such as the nucleus basalis magnocellularis [14] , nucleus accumbens [33] , inferior colliculus, periaqueductal gray [34] , cerebroventricle [35] and ventral hippocampus [36] . We also reported an anxiogenic effect following injection of histamine into the central nucleus of the amygdala in our previous study [37] .…”

Section: Discussionmentioning

confidence: 99%

“…There is agreement that histamine and the histaminergic system have an important role in several physiological processes such as learning and memory [11] , cognition and novel environment-motivated exploration [12] . The involvement of the histaminergic system in the modulation of anxiety-like behaviors in animals has also been suggested [13,14] . Our previous study indicated that the histaminergic system in the central amygdala via H 1 receptors has a role in the modulation of anxiety-related behaviors [15] .…”

Section: Introductionmentioning

confidence: 99%

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GABA and Histamine Interaction in the Basolateral Amygdala of Rats in the Plus-Maze Test of Anxiety-Like Behaviors

Moghaddam

Roohbakhsh

Rostami³

et al. 2008

Pharmacology

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In the present study, we have investigated the effects and the interaction of the GABAergic and histaminergic systems in the basolateral amygdala (BLA) of rats using the plus-maze test of anxiety-like behaviors. Unilateral injection of different doses of muscimol (GABA_A receptor selective agonist; 0.01, 0.05 and 0.1 µg/rat) into the BLA (intra-BLA) increased the percentage of open arm time (%OAT) and open arm entries (%OAE) at the doses of 0.05 and 0.1 µg/rat that are representative of an anxiolytic response. Intra-BLA injection of bicuculline (GABA_A receptor selective antagonist; 0.05, 0.1 and 0.5 µg/rat) decreased %OAT and %OAE at the doses of 0.1 and 0.5 µg/rat showing an anxiogenic-like effect. Intra-BLA administration of histamine (0.05, 0.1 and 0.5 µg/rat) also showed anxiogenic-like effects at the doses of 0.1 and 0.5 µg/rat while intra-BLA administration of pyrilamine (an H₁ receptor selective antagonist; 5, 10 and 20 µg/rat) induced anxiolytic effects at the dose of 20 µg/rat. Coadministration of histamine (0.1 µg/rat) with muscimol reversed the anxiolytic effect of muscimol at the dose of 0.1 µg/rat while coadministration of histamine (0.1 µg/rat) with bicuculline increased the anxiogenic effect of bicuculline at the dose of 0.05 µg/rat. On the other hand, coadministration of pyrilamine (10 µg/rat) with bicuculline decreased anxiety-like behaviors of bicuculline at the dose of 0.5 µg/rat while pyrilamine could not affect the anxiolytic effect of muscimol. In conclusion, it seems that both GABAergic and histaminergic systems not only play a part in the modulation of anxiety-like behaviors in the BLA of rats but may also have opposite effects in this brain region.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

GABA and Histamine Interaction in the Basolateral Amygdala of Rats in the Plus-Maze Test of Anxiety-Like Behaviors

Moghaddam

Roohbakhsh

Rostami³

et al. 2008

Pharmacology

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“…Conversely, certain studies reported the anxiolytic role of CPA in animals (25,32). Indeed, it has been suggested that CPA anxiolysis may be attributed to modulation of the serotonergic and cholinergic systems (7).…”

Section: Discussionmentioning

confidence: 99%

Chlorpheniramine and escitalopram: Similar antidepressant and nitric oxide lowering roles in a mouse model of anxiety

2017

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Abstract. There is a crosstalk between mood disorders and oxidative stress. Chlorpheniramine (CPA), a first generation antihistamine, is hypothesized to have an anxiolytic role at high doses; however, its antidepressant and antioxidant roles have not previously been investigated. The aim of the current study was to evaluate the antidepressant and anxiolytic effects of CPA treatment in association with nitric oxide (NO) and super oxide dismutase (SOD) activity in a mouse model of anxiety. BALB/c mice were divided into unstressed (naïve), control, and CPA-(0.5 mg/kg) and escitalopram-(ESC; 10 mg/kg) treated groups for 3 weeks. Subsequently, they were immobilized for 6 h and subjected to behavioural paradigms as follows: The open field test, the elevated plus maze (EPM) and the forced swim test to investigate motor function, anxiety and depression, respectively. The mice were sacrificed and serum was obtained to detect NO and SOD activity. Compared with the control group, the CPA-treated group demonstrated an antidepressant effect similar to that of the ESC-treated group. In addition, CPA prevented stress-induced NO without affecting SOD activity. CPA did not improve anxiety-like behaviour in the EPM, nor did it improve stress-induced locomotion and rearing, as demonstrated by the OFT. Thus, to the best of our knowledge, this is the first study to evaluate the antidepressant role of CPA in association with NO metabolism. However, further studies are required to elucidate the underlying mechanism.

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“…The tuberomammillary nucleus (TM) is the only source of histaminergic neurons, which project to various parts of the brain including the nucleus accumbens (NAc) and the ventral tegmental area (VTA), regions known to be involved in reward mechanisms [6,7] . A role for brain histamine in regulating reward mechanisms has been recently documented in several studies [8] .…”

Section: Introductionmentioning

confidence: 98%

Endogenous histamine inhibits the development of morphine-induced conditioned place preference

Gong

Zhu

et al. 2007

Acta Pharmacologica Sinica

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The H1- and H2-histamine blockers chlorpheniramine and ranitidine applied to the nucleus basalis magnocellularis region modulate anxiety and reinforcement related processes

Cited by 75 publications

References 88 publications

GABA and Histamine Interaction in the Basolateral Amygdala of Rats in the Plus-Maze Test of Anxiety-Like Behaviors

GABA and Histamine Interaction in the Basolateral Amygdala of Rats in the Plus-Maze Test of Anxiety-Like Behaviors

Chlorpheniramine and escitalopram: Similar antidepressant and nitric oxide lowering roles in a mouse model of anxiety

Endogenous histamine inhibits the development of morphine-induced conditioned place preference

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