Endogenous histamine inhibits the development of morphine-induced conditioned place preference

Gong, Ying-xia; Lv, Min; Zhu, Yimin; Zhu, Yuanyuan; Wei, Er-Qing; Shi, Hong; Zeng, Qingze; Chen, Zhong

doi:10.1111/j.1745-7254.2006.00470.x

Cited by 1 publication

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to this, preclinical evidence suggests that morphine-context associations rely on signaling from another neurotransmitter, hormonal, and neuromodulatory systems, including opioid, GABA, norepinephrine, serotonin, cannabinoid, nitric oxide, hypocretin/orexin, neuropeptide S, and cholecystokinin (Tzschentke, 1998 , 2007 ; Le Merrer et al, 2009 ; Li et al, 2009 ; Billa et al, 2010 ; Karimi et al, 2013 ; Ghavipanjeh et al, 2015 ; Loureiro et al, 2016 ; Zhang et al, 2016 ; Azizbeigi et al, 2019 ) as well as systems involved in immune function and inflammation (Ghahremani et al, 2006 ; Zhang et al, 2012 ; Chen et al, 2017 ). Additionally, evidence suggests that morphine-induced suppression of endogenous histamine is important for morphine CPP as bilateral lesions of the tuberomammillary nucleus, a brain region that expresses histamine-releasing neurons, potentiated the development of morphine CPP (Gong et al, 2007 ). Also, activation of scaffolding proteins such as receptor for activated protein kinase C 1 (RACK1) is necessary for morphine CPP (Wan et al, 2011 ; Liu et al, 2016 ).…”

Section: Neurobiology Of Drug-induced Cpp: Focus On Opioid Cppmentioning

confidence: 99%

Drug-Induced Conditioned Place Preference and Its Practical Use in Substance Use Disorder Research

McKendrick

Graziane

2020

Front. Behav. Neurosci.

126

View full text Add to dashboard Cite

The conditioned place preference (CPP) paradigm is a well-established model utilized to study the role of context associations in reward-related behaviors, including both natural rewards and drugs of abuse. In this review article, we discuss the basic history, various uses, and considerations that are tied to this technique. There are many potential takeaway implications of this model, including negative affective states, conditioned drug effects, memory, and motivation, which are all considered here. We also discuss the neurobiology of CPP including relevant brain regions, molecular signaling cascades, and neuromodulatory systems. We further examine some of our prior findings and how they integrate CPP with self-administration paradigms. Overall, by describing the fundamentals of CPP, findings from the past few decades, and implications of using CPP as a research paradigm, we have endeavored to support the case that the CPP method is specifically advantageous for studying the role of a form of Pavlovian learning that associates drug use with the surrounding environment.

show abstract