The H–Y Transplantation Antigen: A Y-linked or Sex-influenced Factor?

Silvers, Willys K.; Billingham, R. E.; Sanford, Barbara H.

doi:10.1038/220401a0

Cited by 36 publications

(11 citation statements)

References 7 publications

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“…956 a period which should afford ample opportunity for H-Y to develop (assuming that hormonal factors are involved in its induction), the antigen is not synthesized in a form or quantity sufficient to elicit graft rejection. When these long-standing neonatal female grafts are excised from their male hosts and transferred to normal syngeneic females, or to specifically sensitized (male-grafted) females, the grafts are permanently accepted (4). The hormonal hypothesis is also inconsistent with (i) the observation that male hemopoietic cells which colonize lethally irradiated female mice continue to express H-Y (S) and (ii) with the observation that H-Y is expressed on 50 percent of eight-cell mouse embryos (6).…”

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confidence: 99%

H-Y Antigen: Behavior and Function

Silvers¹,

Wachtel²

1977

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H-Y Antigen: Behavior and Function

Silvers¹,

Wachtel²

1977

Science

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“…This may serve to explain why " female " trophoblast has a greater tendency to become moles and the corollary finding that " male " placentas are rejected with a greater frequency as observed in spontaneous abortions (Stevenson and Borrow, 1957;Seer and Ismajovich, 1963). It is possible that a greater antigenic dissimilarity due to the presence of a Y-linked histocompatibility gene (Hauschka, 1955;Eichwald et al, 1958;Silvers et al, 1968) may be responsible for a greater rejection rate of the X-Y trophoblast. Alternatively, the relative success of the X-X trophoblast may be due to a greater production of chorionic gonadotrophic hormone and hence a rise in maternal To protect the uterus against the invading trophoblast may be one of the functions of the decidual reaction (Kirby, 1965).…”

Section: Discussionmentioning

confidence: 99%

A histological study of chromatin positive and negative hydatidiform moles.

Loke¹,

Borland²

1969

Br J Cancer

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PREVIOUS histological studies on trophoblast tumours (Park and Lees, 1950;Hou and Pang, 1956) have made little reference to the maternal reaction around them, except for a recent paper by Elston (1969) who described the cellular reaction to choriocarcinoma. Current observations that most hydatidiform moles (Loke, 1969) and also choriocarcinomas (Tominaga and Page, 1966) are chromatin positive have focused attention on the possibility that there may be a variation in the behaviour of trophoblast tumours of differing chromatin status.This paper presents the findings obtained in a histological study of chromatin positive and negative hydatidiform moles with particular reference to the uterine reaction towards them. A similar analysis was also made on choriocarcinomas for comparison. MATERIALThe material was collected from the Pathology Division of the Institute for Medical Research, Malaya. There were 13 cases of hydatidiform moles with accompanying uteri removed by hysterectomy and one case of ovarian mole. In addition, there were 105 hydatidiform moles which were spontaneously aborted. At the same time, there were 7 cases of uterine choriocarcinoma and one case where the tumour was found in the fallopian tube. RESULTS

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“…It is probable that, at least in some circumstances, graft rejection may wax and wane rather than being a process with a clear outcome (Miyamoto and McCuUagh, 1974). Other possible explanations for partial graft acceptance could be that healing of retransplanted skin grafts occurs less readily because of the increased thickness of the transferred tissue (Silvers, Billingham and Sanford, 1968) or that some phenomenon akin to the patchy rejection of skin grafts from allophenic mice (Mintz and Silvers, 1970) was underway.…”

Section: Discussionmentioning

confidence: 99%

Rejection of Syngeneic Skin Grafts Following Retransplantation From Histo‐incompatible Rats

McCullagh

1985

Aust J Exp Biol Med

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Summary.Normal syngeneic recipients rejected a substantial proportion of skin grafts following their retransplantation after a period of residence on tolerant allogeneic or normal semi-allogeneic hosts. Rejection was often atypical in its delayed onset and protracted course. Examination of the effect of a variety of manipulations of graft donors and of intermediate hosts revealed that active involvement of cells derived from both categories was required for the initiation of an allograft reaction after transfer to the ultimate, syngeneic recipient. Liability of retransplanted syngeneic skin grafts to rejection could be almost entirely abolished by their exposure to 300 rads irradiation before placement on the intermediate host. Skin from neonatally thymectomized donors or from rats specifically tolerant of the intermediate F, hybrid host was much less liable to ultimate rejection than was skin from normal hosts. These experiments suggest that rejection of re-transplanted, syngeneic grafts may result from some form of activation of cells of the graft during its period on the intermediate host.

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The H–Y Transplantation Antigen: A Y-linked or Sex-influenced Factor?

Cited by 36 publications

References 7 publications

H-Y Antigen: Behavior and Function

H-Y Antigen: Behavior and Function

A histological study of chromatin positive and negative hydatidiform moles.

Rejection of Syngeneic Skin Grafts Following Retransplantation From Histo‐incompatible Rats

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