The gut microbiome and depression: finding a way through troubled waters where the river meets the sea

Clarke, Gerard

doi:10.1080/17474124.2020.1754796

Cited by 5 publications

(3 citation statements)

References 44 publications

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“…Patients with MDD often have gastrointestinal disturbances, such as abdominal pain, cramping, bloating, diarrhea, and/or constipation (Walker et al., 1992 ). A direct causative link between the gastrointestinal disturbances and MDD has not yet been established, but the gut microbiota has been suggested to be involved, though its role not yet fully elucidated (Bastiaanssen et al., 2020 ; Capuco et al., 2020 ; Carlessi et al., 2019 ; Caspani et al., 2019 ; Clarke, 2020 ; Cruz‐Pereira et al., 2020 ; Dinan & Cryan, 2019 ; Du et al., 2020 ; Kelly et al., 2019 ; Simpson et al., 2020 ). Gut microbiota has suggested to play a role in the bidirectional communication between the gastrointestinal system and the brain, also known as the gut‐brain axis (Capuco et al., 2020 ; Cryan & Dinan, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota variations in patients diagnosed with major depressive disorder—A systematic review

et al. 2021

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The etiology of major depressive disorder (MDD) is characterized by complex interactions between genetic, biological, and environmental factors (Saveanu & Nemeroff, 2012). Patients with MDD often have gastrointestinal disturbances, such as abdominal pain, cramping, bloating, diarrhea, and/or constipation (Walker et al., 1992). A direct causative link between the gastrointestinal disturbances and MDD has not yet been established, but the gut microbiota has been suggested to be involved, though its role not yet fully elucidated (

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Section: Introductionmentioning

confidence: 99%

Gut microbiota variations in patients diagnosed with major depressive disorder—A systematic review

et al. 2021

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“…The association between depression and changes in the gut microbiome has been revealed by clinical studies, but the causal role of this bidirectional relationship of the microbiome-gut-brain axis has not yet been established. The gut microbiome is a possible source of biomarkers and a target for the treatment of depression, so postbiotics have potential use in new anti-depressant approaches [56,57].…”

Section: Influencing Of Systemic Metabolic Responsesmentioning

confidence: 99%

Postbiotics as Metabolites and Their Biotherapeutic Potential

Hijová

2024

IJMS

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This review highlights the role of postbiotics, which may provide an underappreciated avenue doe promising therapeutic alternatives. The discovery of natural compounds obtained from microorganisms needs to be investigated in the future in terms of their effects on various metabolic disorders and molecular pathways, as well as modulation of the immune system and intestinal microbiota in children and adults. However, further studies and efforts are needed to evaluate and describe new postbiotics. This review provides available knowledge that may assist future research in identifying new postbiotics and uncovering additional mechanisms to combat metabolic diseases.

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“…8,9 Although there has been extensive research into the pathophysiology of depression and anxiety, their diagnosis is still symptom based, with treatment options remaining suboptimal and stubbornly focused on targeting monoamine neurotransmitter pathways. 10 Independently, IBS, depression, and anxiety are complex heterogenous disorders with an already difficult clinical management profile made more challenging when combined in comorbid gastrointestinal and psychiatric phenotypes. 3,8,9 Research in the last decade or more points toward a role of the gut-brain axis in both IBS and psychiatric disorders.…”

Section: Introductionmentioning

confidence: 99%

Of bowels, brain and behavior: A role for the gut microbiota in psychiatric comorbidities in irritable bowel syndrome

Wilmes

Collins

O’Riordan

et al. 2021

Neurogastroenterology Motil

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Background:The gastrointestinal microbiota has emerged as a key regulator of gutbrain axis signalling with important implications for neurogastroenterology. There is continuous bidirectional communication between the gut and the brain facilitated by neuronal, endocrine, metabolic, and immune pathways. The microbiota influences these signalling pathways via several mechanisms. Studies have shown compositional and functional alterations in the gut microbiota in stress-related psychiatric disorders. Gut microbiota reconfigurations are also a feature of irritable bowel syndrome (IBS), a gut-brain axis disorder sharing high levels of psychiatric comorbidity including both anxiety and depression. It remains unclear how the gut microbiota alterations in IBS align with both core symptoms and these psychiatric comorbidities. Methods:In this review, we highlight common and disparate features of these microbial signatures as well as the associated gut-brain axis signalling pathways. Studies suggest that patients with either IBS, depression or anxiety, alone or comorbid, present with alterations in gut microbiota composition and harbor immune, endocrine, and serotonergic system alterations relevant to the common pathophysiology of these comorbid conditions. Keyresults:Research has illustrated the utility of fecal microbiota transplantation in animal models, expanding the evidence base for a potential causal role of disorderspecific gut microbiota compositions in symptom set expression. Moreover, an exciting study by Constante and colleagues in this issue highlights the possibility of counteracting this microbiota-associated aberrant behavioral phenotype with a probiotic yeast, Saccharomyces boulardii CNCM I-745. Conclusions and inferences: Such data highlights the potential for therapeutic targeting of the gut microbiota as a valuable strategy for the management of comorbid psychiatric symptoms in IBS.

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The gut microbiome and depression: finding a way through troubled waters where the river meets the sea

Cited by 5 publications

References 44 publications

Gut microbiota variations in patients diagnosed with major depressive disorder—A systematic review

Gut microbiota variations in patients diagnosed with major depressive disorder—A systematic review

Postbiotics as Metabolites and Their Biotherapeutic Potential

Of bowels, brain and behavior: A role for the gut microbiota in psychiatric comorbidities in irritable bowel syndrome

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