The growth factor independence-1 transcription factor: New functions and new insights

Kazanjian, Avedis; Gross, Eleanore A.; Grimes, H. Leighton

doi:10.1016/j.critrevonc.2006.02.002

Cited by 48 publications

(51 citation statements)

References 101 publications

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“…This indicates that depending on the cellular context, Gfi1 functions as a tumor suppressor or oncogene. 82 Gfi1 can also cooperate with other oncogenes in lymphomagenesis. This is based on the fact that the time to tumor development on Gfi1 overexpression is significantly shortened when mice express other oncogenes like Myc and Pim.…”

Section: Gfi1 In T-cell Development Allergy and Lymphomamentioning

confidence: 99%

Gfi1 and Gfi1b: key regulators of hematopoiesis

2010

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Transcription factor Growth factor independence 1 (Gfi1) is required for multilineage blood cell development, from stem and progenitor cells to differentiated lymphoid and myeloid cells. Gfi1 expression is rapidly induced by cytokines that control both the adaptive and innate immune systems. Gfi1 itself represses the expression of genes implicated in cell survival, proliferation and differentiation. Changes in Gfi1 expression and function have not only been implicated in neutropenia, allergy, autoimmunity and hyperinflammatory responses, but also in lymphoma and more recently in the development of leukemia. In this study, we review how Gfi1 and its paralogue Gfi1b control the development of blood cells, discuss how changes in Gfi1 and Gfi1b function contribute to hematological disease and report on the molecular function of these proteins.

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Section: Gfi1 In T-cell Development Allergy and Lymphomamentioning

confidence: 99%

Gfi1 and Gfi1b: key regulators of hematopoiesis

2010

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“…Here it controls diverse developmental processes, such as cell fate determination, differentiation, proliferation and cell survival (for review, see (50)(51)(52)(53)(54)). Outside the hematopoietic system, Gfi1 mRNA has been detected in a wide range of other tissues, but expression of Gfi1 protein seems to be restricted to mechanoreceptors cells (hair cells and Merkel cells), neurons of the cerebellum and retina, and specialized epithelial cells in the gut and lung (Table 1).…”

Section: Gfi1 and The Gps Family Of Transcription Factorsmentioning

confidence: 99%

Atoh1 in sensory hair cell development: constraints and cofactors

Costa

Powell

Lowell

et al. 2017

Seminars in Cell & Developmental Biology

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The proneural gene, Atoh1, is necessary and in some contexts sufficient for early inner ear hair cell development. Its function is the subject of intensive research, not least because of the possibility that it could be used in therapeutic strategies to reverse hair cell loss in deafness. However, it is clear that Atoh1's function is highly context dependent. During inner ear development, Atoh1 is only able to promote hair cell differentiation at specific developmental stages. Outside the ear, Atoh1 is required for differentiation of a variety of other cell types, for example in the intestine and cerebellum. The reasons for this context dependence are poorly understood. So far, the pathways and key players that instruct Atoh1 to act as a mechanosensory cell fate determinant in the context of the inner ear are largely unknown. Here we review evidence that suggests that Atoh1 function in hair cell differentiation is modulated by interaction with other transcription factors. We particularly focus on the possible roles of Gfi1 and Pou4f3, drawing from studies in mouse, Drosophila and C. elegans.3

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“…G fi-1 encodes a nuclear zinc-finger transcription factor and was first identified as an integration site of Moloney murine leukemia virus in a screen for T cell interleukin-2-independent growth (1,2). Subsequently, Gfi-1 was found to be a frequent target of proviral insertion in T and B cell lymphomas.…”

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confidence: 99%

“…Gfi-1 functions mainly as a repressor of transcription (1,2). It represses its target genes by binding to consensus DNA elements containing the AATC core sequence.…”

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confidence: 99%

Gfi-1 represses CDKN2B encoding p15 ^INK4B through interaction with Miz-1

Basu

Liu

Qiu

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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Gfi-1 is a nuclear zinc finger (ZF) transcriptional repressor that plays an important role in hematopoiesis and inner ear development, and has been implicated in lymphomagenesis. Gfi-1 represses transcription by directly binding to the consensus DNA sequence in the promoters of its target genes. We report here an alternative mechanism by which Gfi-1 represses CDKN2B encoding p15 INK4B . Gfi-1 does not directly bind to CDKN2B, but interacts with Miz-1 and, via Miz-1, is recruited to the core promoter of CDKN2B. Miz-1 is a POZ-ZF transcription factor that has been shown to mediate transcriptional repression by c-Myc. Like c-Myc, upon recruitment to the CDKN2B promoter, Gfi-1 represses transcriptional activation of CDKN2B by Miz-1 and in response to TGF␤. Consistent with its role in repressing CDKN2B transcription, knockdown of Gfi-1 in human leukemic cells or deficiency of Gfi-1 in mouse bone marrow cells results in augmented expression of p15 INK4B . Notably, Gfi-1 and c-Myc are both recruited to the CDKN2B core promoter and act in collaboration to repress CDKN2B. Our data reveal a mechanism of transcriptional repression by Gfi-1 and may have important implications for understanding the roles of Gfi-1 in normal development and tumorigenesis.cyclin-dependent kinase inhibitor ͉ proliferation ͉ transcriptional repressor ͉ tumorigenesis

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The growth factor independence-1 transcription factor: New functions and new insights

Cited by 48 publications

References 101 publications

Gfi1 and Gfi1b: key regulators of hematopoiesis

Gfi1 and Gfi1b: key regulators of hematopoiesis

Atoh1 in sensory hair cell development: constraints and cofactors

Gfi-1 represses CDKN2B encoding p15 ^INK4B through interaction with Miz-1

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The growth factor independence-1 transcription factor: New functions and new insights

Cited by 48 publications

References 101 publications

Gfi1 and Gfi1b: key regulators of hematopoiesis

Gfi1 and Gfi1b: key regulators of hematopoiesis

Atoh1 in sensory hair cell development: constraints and cofactors

Gfi-1 represses CDKN2B encoding p15 INK4B through interaction with Miz-1

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Gfi-1 represses CDKN2B encoding p15 ^INK4B through interaction with Miz-1