The Growth Differentiation Factor 11 is Involved in Skin Fibroblast Ageing and is Induced by a Preparation of Peptides and Sugars Derived from Plant Cell Cultures

Tito, Annalisa; Barbulova, Ani; Zappelli, Claudia; Leone, Marilisa; Ruvo, Menotti; Mercurio, Flavia Anna; Russo, Rosita; Colucci, Maria Gabriella; Apone, Fabio

doi:10.1007/s12033-019-00154-w

Cited by 20 publications

(20 citation statements)

References 45 publications

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“…Genes related to ECM production were also found upregulated after Smad2 and Smad3 activation, in parallel to decrease in IL-1β proinflammatory cytokine-related gene [24]. Indeed, DF produced TGF-β and GDF11 [95,96] in addition to laminin, collagen, elastin, and fibronectin to ensure mechanical stability of the dermis and participated to epidermis cell functions including those of keratinocytes and melanocytes. ADSCs were also reported to secrete ECM proteins participating in this activation loop.…”

Section: Proliferation and Differentiation Of Adscs Into Skin Cellsmentioning

confidence: 97%

“…In the same manner, using platelets-rich plasma (PRP) for anti-wrinkle and anti-aging skin aspects appeared legitime related to its higher quantities of GDF11 [116]. Interestingly, GDF11 expression and activity were reduced in adult DF compared to the neonatal ones [95].…”

Section: Cellular Implicationmentioning

confidence: 99%

“…Fibroblasts were also recognized to play a crucial role in skin regeneration through GDF11 secretion in both neonatal and adult cells [95]. MSCs derived from placenta and umbilical cord blood promote fibroblasts plasticity [117] probably through GDF11 release, thus stimulating the rejuvenation of human skin [118].…”

Section: Cellular Implicationmentioning

confidence: 99%

“…Moreover, by increasing collagenase matrix metalloproteinase-9 (MMP-9) secretion, rGDF11 participated in matrix remodeling maybe through interaction of MMP-9 with TGF-β1 to facilitate skin wound closure [97,122]. These cell interactions reveal the role of the TFG-β and GDF11 mechanisms used by ADSCs to interfere with the aging process [24,95,101].…”

Section: Cellular Implicationmentioning

confidence: 99%

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Adipose-Derived Stem Cells (ADSCs) and Growth Differentiation Factor 11 (GDF11): Regenerative and Antiaging Capacity for the Skin

Mazini¹,

Rochette²,

Malka³

2020

Regenerative Medicine

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Adipose-derived stem cells (ADSCs) have proven their efficiency in wound healing and skin regeneration in vitro and in vivo. They were reported to differentiate into skin cell types and migrate to wounded sites to restore cell deficiencies and functions. Secretome of ADSCs is involved in the migration and proliferation of dermal fibroblasts (DFs) and keratinocytes where growth differentiation factor 11 (GDF11) and transforming growth factor-β (TGF-β) are expected to play the principal role. Both factors are implicated in immune responses, skin cell differentiation, proliferation and pigmentation, migration and secretion of the extracellular matrix proteins. Increasing evidence has pointed the fact that ADSCs are expected to cross-react with GDF11 to ensure DF and keratinocytes proliferation to reverse the aging process. Moreover, these factors share similar intracellular mechanisms pathways that are SMAD-dependent, and target different cellular mechanisms related to regeneration or rejuvenation. This intriguing balance between GDF11dependent aging and TGF-β-dependent regeneration still remains unclear and might be regulated in a spatio-temporal manner. Considering the clinical relevance of the mechanisms slowing or delaying the onset of age, we aimed to clarify the involvement of cell signaling pathways related to GDF11 and TGF-β in balancing cell rejuvenation and cell regeneration. Increasing the organ lifespan and functionality might be challenging issues.

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Section: Proliferation and Differentiation Of Adscs Into Skin Cellsmentioning

confidence: 97%

Section: Cellular Implicationmentioning

confidence: 99%

Section: Cellular Implicationmentioning

confidence: 99%

Section: Cellular Implicationmentioning

confidence: 99%

See 2 more Smart Citations

Adipose-Derived Stem Cells (ADSCs) and Growth Differentiation Factor 11 (GDF11): Regenerative and Antiaging Capacity for the Skin

Mazini¹,

Rochette²,

Malka³

2020

Regenerative Medicine

View full text Add to dashboard Cite

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“…GDF11 expression and activity were decreased in fibroblasts originating from adult donors as compared to neonatal fibroblasts. The induction of collagen I and III was the main effect of GDF11, in both adult and neonatal fibroblasts, by triggering Smad signaling in a TGF-β-like fashion [40].…”

Section: Effects Of Gdf11 On Skin Regenerationmentioning

confidence: 99%

Anti-Aging Effects of GDF11 on Skin

Rochette

Mazini

Méloux

et al. 2020

IJMS

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Human skin is composed of three layers: the epidermis, the dermis, and the hypodermis. The epidermis has four major cell layers made up of keratinocytes in varying stages of progressive differentiation. Skin aging is a multi-factorial process that affects every phase of its biology and function. The expression profiles of inflammation-related genes analyzed in resident immune cells demonstrated that these cells have a strong ability to regenerate adult skin stem cells and to produce endogenous substances such as growth differentiation factor 11 (GDF11). GDF11 appears to be the key to progenitor proliferation and/or differentiation. The preservation of youthful phenotypes has been tied to the presence of GDF11 in different human tissues, and, in the skin, this factor inhibits inflammatory responses. The protective role of GDF11 depends on a multi-factorial process implicating various types of skin cells such as keratinocytes, fibroblasts and inflammatory cells. GDF11 should be further studied for the purpose of developing novel therapies for the treatment of skin diseases.

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Plant Tissue Cultures as Sources of Ingredients for Skin Care Applications

Apone¹,

Tito²,

Arciello³

et al. 2020

Annual Plant Reviews Online

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In order to support their sessile lifestyle, plants evolved sophisticated defence mechanisms that result in the synthesis of a vast spectrum of chemical compounds. Plants have been the main source of natural ingredients for human use since ancient times and nowadays, with the development of plant tissue culture techniques, remarkable progresses towards the production of bioactive compounds on an industrial scale have been achieved, as plant tissue cultures represent standardized, contaminant‐free, and bio‐sustainable systems. In cosmetics, particularly as skin care applications, plant tissue cultures represent a valuable and promising source of active ingredients with a wide range of biological activities. While plant cells, grown as undifferentiated suspension cultures, could be a valuable source of active molecules which are normally synthesized in low amounts in differentiated tissues, hairy roots or somatic embryo cultures, due to their more specialized nature, synthetize compounds that can address more specific functions in skin care; although widespread in the pharmaceutical industry, plant tissue culture technology is not yet very common in the cosmetic field. The aim of the present article is to focus on the successful research accomplishments in the development of plant tissue cultures‐derived active ingredients for cosmetic applications.

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The Growth Differentiation Factor 11 is Involved in Skin Fibroblast Ageing and is Induced by a Preparation of Peptides and Sugars Derived from Plant Cell Cultures

Cited by 20 publications

References 45 publications

Adipose-Derived Stem Cells (ADSCs) and Growth Differentiation Factor 11 (GDF11): Regenerative and Antiaging Capacity for the Skin

Adipose-Derived Stem Cells (ADSCs) and Growth Differentiation Factor 11 (GDF11): Regenerative and Antiaging Capacity for the Skin

Anti-Aging Effects of GDF11 on Skin

Plant Tissue Cultures as Sources of Ingredients for Skin Care Applications

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